[Irradiation effects on the tumor and adjacent tissues of brain tumor-bearing mice (author's transl)].
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Biomedical subjects
Publications and source records attributed to Y Umegaki.
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An analysis of computer requirements in radiation therapy departments is presented. The performance and structure of an effective computer system designed for large or small radiotherapy departments are described. The system is composed of two or three sets of minicomputer-based subsystems of which can be operated alone or connected to other subsystems. The size of the system can be adjusted to the size of the radiotherapy department. The system covers treatment planning, automatic control, and record processing.
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Construction of a new ultrafast scanner system suitable for dynamic computed tomography is now under consideration, with development soon to begin. This system will be characterized by an electronically controlled X-ray generator with wide angle double diffraction, which will permit transverse axial images to be taken in times as short as 0.01 second.
A study of the automated diagnosis of luxatio coxae congenita (LCC) was performed to establish an automated screening system for hip radiographs. A specific parameter with high diagnostic accuracy was selected by the use of information theory. Pattern recognition programs were written to extract the parameter from digitized hip radiographs. Parameter measurement was performed on 10 radiographs and compared with manual measurements. Results showed good agreement with measurements obtained by specialists. This study confirms the possibilities of automated diagnosis of LCC.
Ammonia has been known to be an inducing agent of hepatic coma associated with liver cirrhosis. In order to establish a non-invasive method of investigating the portal circulation and the metabolism of ammonia at liver the following studies were performed, by using cyclotron produced 13N-labeled ammonia and delayed line-camera interphased with on-line computer system. 1) Animal experiment. Dynamic scintigraphy of thoraco-abdominal region of a rabbit after intrasigmoidal as well as intravenous administration of 13N-ammonia were performed. 2) Theoretical consideration on the functional image of liver: According to the results of the animal experiments, a model of ammonia metabolism having the minimal complexity necessary to represent data in the case of intrasigmoidal administration was proposed. Starting from the solution to the differential equation describing the model, relevant parameters characterizing the dynamic curve of liver were duded.
1) Clinical application: Dynamic scintigraphy of liver and heart of a patient having liver cirrhosis after intrasigmoidal administration of 13N-ammonia (pH 8.1) were performed. Simultaneously, continuous measurments of radioactivity at the left side abdomen and the left temporal region were done by using a scintillation detector for renography. Successive measurement of radioactivity of blood was also carried out. 2) Comstruction of functional images of liver and heart: By using digital radioisotope image of liver and heart of the patient after intrasigmoidal administration of 13N-ammonia, the maps with respect to parameters described in the pervious paper were constructed.
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