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Biomedical subjects

Y Ueda

Publications and source records attributed to Y Ueda.

At least 1,171 records · Page 65Linked to original sources
PubMed1975

Studies on protein folding, unfolding and fluctuations by computer simulation. I. The effect of specific amino acid sequence represented by specific inter-unit interactions.

A lattice model of proteins is introduced. "A protein molecule" is a chain of nown-intersecting units of a given length on the two-dimensional square lattice. The copolymeric character of protein molecules is incorporated into the model in the form of specificities of inter-unit interactions. This model proved most effective for studying the statistical mechanical characteristics of protein folding, unfolding and fluctuations. The specificities of inter-unit interactions are shown to be the primary factors responsible for the all-or-none type transition from native to denatured states of globular proteins. The model has been studied by the Monte Carlo method of Metropolis et al., which is now shown applied to approximately simulating a kinetic process. In the strong limit of the specificity of the inter-unit interaction the native conformation was reached in this method by starting from an extended conformation. The possible generalization and application of this method for finding the native conformation of proteins form their amino sequence are discussed.

Amino Acid Sequence↗
PubMed1975

IgA glomerulonephritis in Japan.

A clinicopathological study was done on 85 Japanese patients with IgA glomerulonephritis. Of patients with glomerulonephritis whose clinical course is of slow progression, the presence of IgA glomerulonephritis was demonstrated immunohistologically. The majority of such patients presented with a mild degree of proteinuria and/or persistent microscopic hematuria. In 15% of the patients, recurrent gross hematuria was noted. These findings suggest that immunohistological study is important in dealing with adult patients with so-called idiopathic renal hematuria. Light-microscopic findings of IgA glomerulonephritis were divided into 4 groups. In 56% of the patients, diffuse stalk thickening of the mesangium was noted and in one third of them, small crescent formations were present. In 22% of the patients, focal segmental proliferation was noted. Diffuse mesangial deposition of IgA noted by immunofluorescence was considered to correspond to the characteristic nodular deposition detected by light microscopy and to the relatively large globular hemispheric deposits detected by electron microscopy.

Female↗