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Biomedical subjects

Y Uchida

Publications and source records attributed to Y Uchida.

At least 721 records · Page 40Linked to original sources
PubMed1983

[Coexisting malignant lymphoma and early cancer of the stomach].

A 62-year-old man with malignant lymphoma and early gastric cancer as two independent growths in the stomach was reported. In the resected stomach, malignant lymphoma was observed as a protruding lesion measuring 5.5 X 3.0 X 1.2 cm with four giant folds at the anterior wall of the upper gastric body. There also was a poorly differentiated adenocarcinoma as an early gastric cancer of type IIc + III; it measured 0.9 X 0.7 cm and invaded the submucosal layer at the antral portion. There were no pathological findings, excepting intestinal metaplasia, in the mucosal layer between the two lesions. There was no metastasis from either the malignant lymphoma or the adenocarcinoma to perigastric lymph nodes.

Adenocarcinoma↗
PubMed1982

Monoclonal alloantibodies specific for the constant region of T cell antigen receptors.

We established three distinct monoclonal antibodies (7C5, 7D1; IgM and 6A4; IgG1) by the fusion of P3U1 and BALB/c (Igh-1a) spleen cells hyperimmunized with T cell blasts from the immunoglobulin heavy chain (Igh) allotype congenic CB-20 (Igh-1b) mice. The 7C5 or 6A4 antibody reacts with the constant region determinants on the antigen-binding molecule (Ct) of the antigen-specific suppressor T cell factor (TsF) or augmenting T cell factor (TaF), respectively. The 7D1 antibody, however, recognizes the shared determinants on the Ct molecules of TsF and TaF. Genetic studies of determinants recognized by these monoclonal antibodies have also suggested that the distinct Ct molecules of TsF and TaF are encoded by two discrete genes linked to the Igh-1b genes, which are located on the right side of the variable genes of Igh on the 12th chromosome. By using the immunoadsorbent columns of 6A4 antibody and anti-I-Ab, TaF, in a manner similar to TsF, was demonstrated to be composed of two chains, i.e., the Ct molecules and the I-A-encoded products. Furthermore, the Ct-bearing molecules were shown to possess the antigen-binding moiety.

Animals↗
PubMed1982

Prophylactic effect of neuroleptics in symptom-free schizophrenics.

Prophylactic effects of psychotropic drugs on 55 schizophrenics in remission were evaluated for 3 years in a double-blind controlled study employing a cross-over design. Patients were randomly assigned to the following drugs orally administered twice a day: placebo; diazepam 15 mg; imipramine 50 mg; chlorpromazine 75 mg; and haloperidol 3 mg. The number of days of remission for each patient was recorded. Since only two patients received all five drug treatments, the data were analyzed using the number of days allocated to the "first assigned drugs" only and the cross-over aspect of the experimental design was disregarded. All patients treated with either the placebo, diazepam or imipramine relapsed within a year. On the other hand, four patients treated with chlorpromazine, or with haloperidol, were in remission for more than 1 year. Fifty percent of the patients relapsed within 16 days with placebo; 88 days with diazepam; 30 days with imipramine; 165 days with chlorpromazine; and 74 days with haloperidol. Within a year, only chlorpromazine significantly prolonged the remission state as compared to placebo and imipramine. At the end of the 3-year trial, both chlorpromazine and haloperidol significantly prolonged the remission state as compared to the other three drugs. These data suggest that neuroleptic treatment for a longer period is vitally important to prevent relapse even in schizophrenics in remission and that such a trial seems an efficient method for investigating the prophylactic effects of neuroleptics.

Adult↗
PubMed1982

Experimental studies of reflux esophagitis following total gastrectomy in rats-pathogenesis and treatment.

Reflux esophagitis was successfully produced in all rats operated on by total gastrectomy and esophagojejunostomy. Its histopathological features comprised erosion and ulceration associated with inflammatory cell infiltration, with hyperplasia of the mucosal epithelium in some animals. These rats were dosed with sodium polyacrylate for protecting the mucosal surface, underwent jejunal diversion for preventing the reflux of digestive juice, or were treated with both in combination, to observe the repairing status of the esophageal ulcer, using the ratio of the length of the regenerated epithelium in the ulcer to the length of the ulcer as the index for the degree of repair. The oral ingestion of 5% sodium polyacrylate solution in drinking water proved the most effective means of administration of this agent. The repair was more improved greater in the group undergoing jejunal diversion, and was greatest in the group receiving both in combination. From these findings, oral administration of a mucosal surface protector, sodium polyacrylate, is an effective therapeutic regiment in mild cases of reflux esophagitis following total gastrectomy, as well as elimination of the cause by diversion of the route in severe cases. The combination of the two therapies will probably by the most effective therapeutic means for this disease.

Acrylic Resins↗
PubMed1982

Changes in the levels of prostaglandins and thromboxane and their roles in the accumulation of exudate in rat carrageenin-induced pleurisy--a profile analysis using gas chromatography-mass spectrometry.

Injection of lambda-carrageenin into the pleural cavity of rats caused the accumulation of the pleural exudate. When levels of prostaglandins (PGs) and thromboxane (TX) B2 were quantified by gas chromatography-mass spectrometry as their methyl ester (ME)-dimethylisopropylsilyl (DMiPS) ether or ME-methoxime-DMiPS ether derivatives, 6-keto-PGF1 alpha reached the maximum at 1 hr after carrageenin, then PGE2 and TXB2 showed peaks at 3 hr and waned off before 9 hr. The PGF/ alpha level was kept low, but PGD2, PGE1 and PGF1 alpha were not detected. Aspirin (100 mg/kg, i.p.) significantly decreased the PG and TXB2 levels and suppressed the rate of plasma exudation until 5 hr, but did not at 7 hr, when it was measured by the amount of exuded pontamine sky blue injected intravenously. OKY-025 (300 mg/kg, i.p.), a selective TXA synthetase inhibitor, and tranylcypromine (20 mg/kg, i.p.), a PGI synthetase inhibitor, could not extensively inhibit the accumulation of the exudate. These results suggest that the cyclooxygenase products of arachidonic acid, particularly PGE2, definitely play an important role in the exudation during the first 5 hr.

Animals↗
PubMed1982

Treatment of angina pectoris by percutaneous transluminal coronary angioplasty.

Percutaneous transluminal coronary angioplasty (PTCA) was performed on 12 patients with angina pectoris. PTCA reduced the percentage of stenosis of the coronary artery from 75.6 +/- 10.1 (means +/- SD) to 32.6 +/- 19.5. In addition, anginal attacks per week was reduced from 8.4 +/- 3.2 to 2.5 +/- 0.7. No life-threatening complications were produced by PTCA. The results indicates the effectiveness of PTCA as a treatment for angina pectoris.

Aged↗
PubMed1982

Effect of intracerebroventricular administration of chlorpromazine on the serum level of free fatty acids in rats.

The effect of intracerebroventricular administration of chlorpromazine (CPZ) on the serum level of free fatty acid (FFA) was studied in rats. Injection of CPZ into the lateral ventricle caused a transient decrease in serum FFA, showing the lowest level after 30 min. This decrease in serum FFA caused by CPZ was significantly inhibited by simultaneous injection of dopamine or apomorphine, although noradrenaline and serotonin had no effect. The dopaminergic blocking agent haloperidol caused a rapid decrease in serum FFA. After central chemical sympathectomy with the intracerebroventricular injection of 6-hydroxydopamine, the response to CPZ of serum FFA was completely abolished; but after peripheral sympathectomy by i.v. injection of 6-hydroxydopamine, a partial inhibition of the action of CPZ was shown. These results suggest a possible involvement of the central dopaminergic mechanism in the decrease in serum FFA after intracerebroventricular injection of CPZ.

Animals↗
PubMed1982

Cardiovascular effect of [3,4-dihydro-8-(2-hydroxy-3-isopropylaminopropoxy)-3-nitrato-2H-1-benzopyran] (K 351).

Cardiovascular effect of a new compound, K 351, was examined in anesthetized dogs. Intravenous injections of 100 micrograms/Kg or over of K 351 caused a fall in systemic blood pressure, reduced peripheral vascular resistance, left ventricular enddiastolic pressure, max dP/dt and Vmax, and increased time constant T and PQ interval. Heart rate was reduced with 1 microgram/Kg K 351. The magnitudes of the changes in heart rate, T and PQ interval were not different between K 351 and propranolol groups, while those in max dP/dt and Vmax caused by K 351 were larger than those induced by the same doses of propranolol. It is suggested that K 351 suppressed left ventricular contractility, sinus node activity and atrioventricular conduction through its beta-receptor blocking action and reduced peripheral vascular resistance and left ventricular enddiastolic pressure through its vasodilating action.

Adrenergic beta-Antagonists↗