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Biomedical subjects

Y Torii

Publications and source records attributed to Y Torii.

At least 163 records · Page 9Linked to original sources
PubMed1982

Purification of placental anemia inducing factor (PAIF) and its clinical application by radioimmunoassay.

Human Placental Anemia Inducing Factor (PAIF) was purified from crude placental preparation called P- 62, which had common biological and immunological natures with the same preparation from gastric juice, gastric tissues, serum and urine of patients with malignant neoplasma, especially gastric cancer. The obtained PAIF was homogeneous on polyacrylamide gel electrophoresis and gave a specific band in the region of gamma-A and/or gamma-M globulin on immunoelectrophoresis. The purified PAIF induced anemia in rabbits by intravenous administration at a dose of 2.7 micrograms/Kg of body weight. No cross antigenicity of PAIF was observed with alpha-Fetoprotein. HBs antigen and CEA. Serum AIF of patients was measured using PAIF as a standard by radioimmunoassay. AIF levels in sera of patients with malignant neoplasma were significant high compared with those of control groups.

Animals↗
PubMed1982

Comparative study of two methods of estimating sinoatrial conduction time in patients with abnormal sinus node function.

This study compared a new method to estimate sinoatrial conduction time (SACT) using continuous atrial pacing proposed by Narula et al with the widely used method using premature atrial stimulation originally proposed by Strauss et al. The estimated SACTs by the two methods were obtained in 19 patients with normal sinus node (SN) function (Group A) and 8 patients with abnormal SN function (Group B). Estimate of the SACT by the Narula method was taken as the difference between the first atrial return cycle after pacing and the basic sinus cycle length (BSCL). The Narula method was performed for a train of 8 consecutive beats at three different pacing cycle length (PCL); PCL (1) greater than or equal to BSCL--50, PCL (2) greater than or equal to BSCL--100 and PCL (3) greater than or equal to BSCL--150 msec. In group A, the estimated SACTs by the Strauss method was 185 +/- 49.3 msec, meanwhile the SACTs by the Narula method were 148 +/- 80.7 at PCL (1), 181 +/- 58.7 at PCL (2) and 212 +/- 84.5 msec at PCL (3) (mean +/- SD); the coefficient of correlation between the Strauss method and the Narula method were 0.58, 0.84, and 0.67, respectively. On the other hand, in group B, atrial return cycles by the Narula method were abnormally prolonged (over 215 msec) in 5 of 8 cases (63%) even at PCL (2) and in all of the cases (100%) at PCL (3). By the Strauss method, SACTs in 6 of 8 cases could not be defined; however it was possible to assess the type of SN dysfunction by the pattern of the atrial return cycles. In conclusion, the estimated SACT by the Narula method at PCL (2) corresponded well with the SACT by the Strauss method in patients with normal SN function. However, it was difficult to determine SACT in patients with Sick Sinus Syndrome by both methods.

Adult↗
PubMed1982

[Two-dimensional echocardiographic evaluation of the right ventricular wall in hypertension and hypertrophic cardiomyopathy].

The thickness and motion of the right ventricular wall (RVW) were studied with two-dimensional echocardiography from a subxiphoid approach in 20 normal subjects (N Group), 86 patients with hypertension (HT Group) and 20 patients with hypertrophic cardiomyopathy (HCM Group). Comparison was made between the patients with and without echocardiographic RVW hypertrophy in each patient group in regard to the thickness of the interventricular septum (IVS) and the left ventricular posterior wall (LVPW) as well as the motion of the RVW and cardiac catheterization data. 1. RVW hypertrophy was visualized in 39.5% of the HT Group and in 40% of the HCM Group. There was no difference in the thickness of RVW between the two groups. 2. A localized hypertrophy and an abnormal motion of RVW were obtained in the HCM Group, but not in the HT Group. 3. RVW hypertrophy in the HT Group was seen in patients with marked IVS hypertrophy, while that in the HCM Group was not related to IVS hypertrophy. 4. Pulmonary arterial pressure remained normal in each group. Therefore, RVW hypertrophy did not appear to be the result of pressure overload. 5. Right atrial mean pressure and right ventricular end-diastolic pressure were elevated only in HCM patients with RVW hypertrophy. We conclude that there is a different mechanism in the mode of production of RVW hypertrophy between patients with hypertension and those with hypertrophic cardiomyopathy.

Cardiac Volume↗
PubMed1982

[Analysis of end-systolic pressure-volume relation by gated radionuclide angiocardiography].

Left ventricular end-systolic pressure-volume relation has been proved experimentally to be an useful index of left ventricular contractility relatively independent of preload or afterload. But less clinical application has been reported because of its invasive nature, and we evaluated this relationship non-invasively using gated radionuclide angiocardiography as volume determination and cuff sphyngomanometer in the arm as pressure measurement. Gated equilibrium blood pool scintigrams were obtained at rest and during intravenous infusion of angiotensin or nitrate. Ventricular volumes were derived from ventricular activity and peripheral blood volume and activity. The peak systolic pressure (PSP) by cuff method to end-systolic volume index (ESVI) relations showed good linearity (r greater than .930 in 84% of consecutive 50 cases) and were gentler in the groups with more impaired left ventricular function. Emax was related exponentially to ejection fraction (EF) and hyperbolically to end-diastolic volume index. The dead volume (VoI) was unfixed and fell into positive or negative value, and was not related to EF under control condition. PSP/ESVI in each loading condition was less variable with the alteration of blood pressure than EF. The linear relation was found between PSP/ESVI under control condition and Emax (PSP/ESVI = 0.651 . Emax + 0.958, r = 0.841, p less than .001). Thus in measuring ventricular volume, gated radionuclide angiocardiography is a non-invasive method less affected by the geometry of the left ventricle. Non-invasive determination of end-systolic pressure-volume relation using the volume by radionuclide and the blood pressure by cuff method is clinically useful in the assessment of left ventricular contractility.

Angiocardiography↗