Lipoperoxides in homogenates of regenerating rat liver increased from 6 hours after the operation and reached a peak (about 7 times the control level) 18-24 hours after the operation. The concentration of blood lipoperoxides rapidly decreased after the operation. The enzymatic activities of superoxide dismutase, catalase, and glutathione peroxidase, and vitamin E content in regenerating livers were also determined. Among these antioxidant factors, the catalase level changed markedly.

Animals↗

PubMed1982

Transrectal longitudinal ultrasonotomography of the prostate by electronic linear scanning.

Transrectal longitudinal ultrasonotomography of the prostate with the newly developed electronic linear scanning method was done on 100 cases and the characteristic echo patterns for each prostatic disease were obtained. With this method we can observe real-time longitudinal tomograms of the prostate, seminal vesicles and bladder. Real-time observations make it easier to examine the relationship between the prostate and its surrounding organs, especially the bladder neck and the prostatic urethra, at the time of urination.

Adult↗

PubMed1982

Blood and tissue levels of lipoperoxides in rats during development.

The excessive accumulation of lipoperoxides has been accepted as being highly responsible for the development of retinopathy of prematurity and idiopathic respiratory distress syndrome of the newborn infant. We have studied development-related levels of lipoperoxides in blood and tissues such as the liver, lungs, kidneys and brain from birth to adult age using rats as the experimental animal. Lipoperoxide concentrations in blood and tissues were low in fetal and early newborn periods. The concentrations increased with age and peaked in the early newborn period and gradually decreased as the development progressed. In vitro lipoperoxide formation and accumulation in tissues exhibited a close correlation with in vivo lipoperoxide concentrations, except in the brain.

Aging↗

PubMed1982

Lipid peroxidation and antioxidants in rat liver during development.

The concentration of lipid peroxidation was extensively high in rat fetuses and early newborns. However, it declined sharply thereafter. Superoxide dismutase (SOD) activity was approximately 10% of the adult level during 5 days postpartum. The enzyme activity began to increase after the 10th day to 60% of the adult level at the 20th day. Catalase activity was low in the fetal period, corresponding to approximately 20% of the adult level, but increased rapidly after birth reaching approximately 50% of the adult level at 5-7 days postpartum. Glutathione peroxidase (GSH-Px) activity was measured to amount to only 7% of the adult level in the fetal and early newborn period. The level of this activity was approximately 20% of the adult level at the 20th day. The difference in GSH-Px activity became wide between sexes after the first 30 days of life; the male adult level was 61% of the female adult level. The concentration of vitamin E was low in the fetus. It increased by a factor of 10 times within a few days after birth, and thereafter it decreased gradually. Fetal and early newborn livers have low enzymatic defense capabilities against possible deleterious effects of lipid peroxidation processes.

Aging↗

PubMed1982