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Biomedical subjects

Y Suzaki

Publications and source records attributed to Y Suzaki.

32 records · Page 2Linked to original sources
PubMed1996

Nonhuman primate models of measles.

Wild measles virus isolated in a marmoset lymphoblastoid B95a cell line induced rashes and Koplik's spots when inoculated parenterally in cynomolgus and squirrel monkeys. Marked leukopenia. associated with transient decrease in the CD4(+)-to-CD8+ T-cell ratio also was induced. Virus growth, as well as histologic lesions of necrosis and giant cell formation, was observed in the lymphoid tissues. Thus clinical signs of acute measles were successfully induced in monkeys by inoculation with cell-culture-grown measles virus. These nonhuman primate models of measles will be useful for study of the pathogenesis of acute measles virus infection in terms of generalized clinical signs of disease, leukopenia, and changes in the lymphocyte subsets.

Animals↗
PubMed1995

Efficacy of systemic corticosteroid treatment for anosmia with nasal and paranasal sinus disease.

Systemic administration of corticosteroids was attempted in the treatment of olfactory loss resistant to topical corticosteroid treatment in patients with nasal and paranasal disease and post-upper respiratory infection. Significant efficacy was achieved with a short course of high-dose oral corticosteroids in patients with non-allergic sinus disease. On the other hand, anosmia induced by upper respiratory infection failed to respond to systemic corticosteroid treatment, suggesting permanent damage to the olfactory receptor cell. The underlying mechanism of effectiveness observed in patients with sinus disease may be explained by improvement of the mucosal thickening of the olfactory fissure, leading to the access of an odorant to the olfactory neuroepithelium.

Administration, Intranasal↗
PubMed1994

[Progress of preoperative diagnosis of pancreatic tumor--with special reference to extension of pancreatic cancer].

Preoperative diagnosis of the extension of pancreatic cancer is very important for determining the range of resection. We evaluated the preoperative imaging diagnosis of the tumors and compared it with the pathological diagnosis. Out of 68 pancreatic head cancers, the percentage of correct diagnosis of serosal invasion was 69.1%, that of over-estimate was 23.5% and that of under-estimate was 7.4%. In the case of retroperitoneal invasion, a correct diagnosis had been made in 79.1%, over-estimate in 4.5% and under-estimate in 16.4%. In the case of portal vein invasion, these percentages were 52.8%, 39.6% and 7.5%, respectively. In the case of lymph node involvement, these percentages were 85.3%, 2.9% and 11.8%, respectively. The percentage of preoperative over-estimate was higher for serosal invasion and that of preoperative under-estimate was higher for retroperitoneal invasion. In the case of portal vein invasion, the percentage of preoperative over-estimate was relatively high. Of the 12 patients who had paraortic lymph node metastases, 6 patients had a single metastatic node in the paraortic area. The minimum size of these nodes was 2 x 2 mm. Only 5 cases could be diagnosed preoperatively. We evaluated the usefulness of abdominal CT scan and superior mesenteric arteriography for the diagnosis of superior mesenteric arterial wall invasion. In both methods, the over-estimate rate was 0%, but the under-estimate rate was relatively high. Conclusively the preoperative diagnosis of the extension of the pancreatic cancer by conventional imaging methods has some limits.

Humans↗
PubMed1993

Endometriosis in cynomolgus monkeys retired from breeding.

Twenty-seven cases of endometriosis were found in 94 female cynomolgus monkeys retired from breeding. The ages of the affected monkeys (28.7% of all the monkeys) ranged from 11 years to 23 years of age with an average of 15.3 years. There was no significant difference in the incidence of endometriosis between groups which had or had not undergone a cesarean section. Time after the last pregnancy was significantly longer in the affected monkeys than in the non-affected ones. These cases were histopathologically classified into four types: 1) pelvic endometriosis with formation of endometrial cysts (51.8% of the affected monkeys), 2) pelvic endometriosis invading other organs without formation of endometrial cysts (3.7%), 3) uterine adenomyosis (22.2%), 4) combined pelvic endometriosis and uterine adenomyosis (22.2%).

Age Factors↗
PubMed1989

Purification and characterization of cytochromes P-450 from liver microsomes of 3-methylcholanthrene-treated crab-eating monkeys.

Two forms of cytochrome P-450 (P-450MC1 and P-450MC2) were purified from liver microsomes of crab-eating monkeys (Macaca irus) treated with 3-methylcholanthrene (MC). Monkey P-450MC1 preparation had a specific content of 14.0 nmol/mg protein and showed a main protein band with a minimum molecular weight of 52,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Monkey P-450MC2 preparation had a specific content of 12.1 nmol/mg protein and a minimum molecular weight of 54,000. The carbon monoxide-reduced difference spectral peaks of monkey P-450MC1 and P-450MC2 were at 448 and 447 nm, respectively. In the reconstituted system, monkey P-450MC2 had high activities for benzo[a]pyrene 3-hydroxylation and 7-ethoxycoumarin O-deethylation. Monkey P-450MC1 had low activities toward these two substrates and a high activity for benzphetamine N-demethylation. Monkey P-450MC1 and P-450MC2 were detected by immunoblotting using an antibody prepared against rat cytochrome P-450c, which is a major form of cytochrome P-450 in liver microsomes of MC-treated rats. These results suggested that the molecular properties of cytochrome P-450 in liver microsomes of crab-eating monkeys treated with MC are similar to those in rats.

Animals↗
PubMed1988

[Canonical discriminant analysis for pregnancy-related changes in hematological and serum biochemical values in tamarins (Saguinus spp].

Hematological and biochemical values obtained from 9 monkeys (Saguinus labiatus and S. mistax) during pre- and postpartum periods were analyzed by canonical discriminant analysis (discriminant analysis with reduction of dimensionality). All animals used were of wild origin and had been maintained under uniform environmental conditions at N. I. H., Japan. The items examined were as follows: white blood cell count (WBC), red blood cell count (RBC), hematocrit value (Ht), hemoglobin concentration (Hb), total protein concentration (TP), blood urea nitrogen (BUN), albumin concentration (ALB), albumin-globulin ratio (A/G), glutamic oxaloacetic transaminase activity (GGT), glutamic pyruvic transaminase activity (GPT), alkaline phosphatase activity (ALP) and total cholesterol concentration (CHO). The data obtained in the pre- and postpartum periods were divided into six chronological groups. The prepartum period was divided into Group I: weeks 15-10; Group II: weeks 9-7; Group III: weeks 6-4; and Group IV: weeks 3-0. The postpartum period was divided into Group V: weeks 0-4 and Group VI: weeks 5-7). In the later pregnancy period (Groups III and IV), significant decreases in RBC, Ht, Hb, TP and ALB, and a significant increase in CHO were observed. These values in the blood and serum continued after delivery (Groups V and VI). Results of canonical discriminant analysis showed that the value of the first canonical variate decreased according to the progress of pregnancy. The postpartum groups showed negative values. Although groups in the early

Analysis of Variance↗
PubMed1980

Detection of macaque chorionic gonadotropin in the placenta of the cynomolgus monkey (Macaca Fascicularis).

The biologically detectable period of macaque chorionic gonadotropin (mCG) was estimated by the mouse uterine weight method with 22 placentas of the cynomolgus monkey at various pregnancy stages. The hormone was detectable in the placental extracts of the 4th and 5th week of gestation, but not in those of the 6th week or later. This fact may be compatible with our previous finding that mCG was not detectable in urine after the 6th week of gestation in the cynomolgus monkey.

Animals↗
PubMed1978

Weight and size of the placenta in cynomolgus monkeys (Macaca fascicularis).

A gross anatomical survey of the placental development was carried out in 24 cynomolgus monkeys (Macaca fascicularis) of 4, 5, 6, 7, 8, 9, 10, 15 and 20 weeks of gestational age. Eight of the 24 placentas examined were found to be single discoidal and the remaining 16 bidiscoidal. The weight and size of placentas of each animal were measured. The average weight of the 20th week placentas was about 94 times heavier than that of the 4th week ones; the average diameter of the former was about 5 times larger than that of the latter.

Animals↗
PubMedDate not supplied

Assessment of postoperative digestive function after pancreatico-duodenectomy: a comparison of reconstruction techniques.

BACKGROUND/AIMS: Malabsorption is a frequent complication following pancreatico-duodenectomy (PD) for pancreatic carcinoma. Gastrojejunostomy followed by Billroth I type of reconstruction (PD III) has been advanced to prevent this disorder. We compared postoperative digestion and absorption determined by 131I-triolein, D-xylose and pancreatic function diagnostant (PFD) after extensive PD followed by one of two reconstructive procedures. MATERIAL AND METHODS: Postoperative digestive and absorptive functions in patients operated by Child's method (PD II) were compared with patients in whom the stomach emptied proximal to the pancreas and bile duct (PD III). RESULTS: The absorption of D-xylose was significantly higher (1.24 +/- 0.36 g vs. 0.72 +/- 0.21 g) in the PD III group. No difference was noted in pancreatic endocrine secretion between the two groups. Biliary scintigraphy revealed increased bile secretion in the PD III group. CONCLUSIONS: These results suggest that PD III is superior to PD II following extensive PD.

Anastomosis, Surgical↗
PubMedDate not supplied

A new technique for variable-load cholangiomanometry. Implication for biliary tract surgery.

BACKGROUND/AIMS: Variable-load cholangiomanometry was performed to obtain data on terminal biliary function during the surgical treatment of cholelithiasis. The decision of whether or not to perform a definitive biliary drainage procedure was based on the results of this test. MATERIAL AND METHODS: The rate of perfusion was reduced in four steps from 15.3 ml/min to 1.2 ml/min, and the resultant perfusion pressures were plotted. The gradient produced by the straight line was considered the resistance, R. The baseline pressure without perfusion was regarded as the static pressure, P. RESULTS: A review of 444 patients with cholelithiasis who underwent intraoperative cholangiomanometry during the past 11 years led to the following indications for definitive biliary drainage: (1) R > 10 units and P > 200 mm H2O, (2) if only R or P is elevated, priority is given to R, and (3) if the elevation of R or P is borderline, the presence of a type I curvature in the segment of low flow rate is an indication for surgery. CONCLUSION: By performing an intraoperative cholangiomanometry concrete indications for a biliary drainage procedure can be defined.

Cholelithiasis↗