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Biomedical subjects

Y Sorokin

Publications and source records attributed to Y Sorokin.

At least 55 records · Page 3Linked to original sources
PubMed1989

Pregnancy and primary biliary cirrhosis.

Pregnancy is rarely encountered in patients with primary biliary cirrhosis. Ten pregnancies in nine patients have been reported in the literature. All five pregnancies that continued beyond the 31st week had increasing jaundice during late pregnancy. We describe a case of primary biliary cirrhosis with symptomatic onset at age 19, pregnancy a year later, with subsequent resolution of jaundice and pruritus. This course is different than most described by others.

Adult↗
PubMed1989

Treatment of hirsutism with cimetidine: a prospective randomized controlled trial.

Cimetidine (Tagamet, Smith Klein, Brussels, Belgium) the histamine receptor type 2 blocker, has been suggested as a possible treatment of hirsutism. In a prospective randomized controlled trial, cimetidine 1.5 gm a day was given for 3 months to 12 moderately or severely hirsute women, while 8 other women were randomized to serve as a control group. There was no significant change in the hair growth rate in either group as measured by two assessment methods. This finding suggests that cimetidine, given in the recommended dose for a period of 3 months, does not have a beneficial effect on hirsutism.

Adolescent↗
PubMed1989

The fertilization and cleavage rates of eggs recovered from the cul-de-sac.

Five hundred ninety-one oocytes were laparoscopically recovered in 93 consecutive stimulated cycles. Fifty-three of the 591 oocytes were collected from the cul-de-sac in 39 cycles. The cul-de-sac-originated oocytes had fertilization and cleavage rates of 72 and 79%, respectively; these rates were similar to those achieved in oocytes originating from follicles. A significant decrease in the fertilization rate of cul-de-sac-originated oocytes was noticed in oocytes collected from the cul-de-sac 60 minutes or more after the beginning of the procedure. Oocytes collected from the cul-de-sac yielded 21% of the embryos transferred in cycles where some of the oocytes were recovered from the cul-de-sac. These findings indicate that repeated aspirations of the cul-de-sac may increase the number of embryos transferred.

Body Fluids↗
PubMed1989

Oral contraceptive pills and follicular fluid hormones in an in vitro fertilization program.

Fluids were collected from 136 ovarian follicles of 35 women undergoing in vitro fertilization and embryo transfer (IVF-ET). Fifteen women (76 follicles) received oral contraceptive pills (OCs) prior to ovulation induction. All women received human menopausal gonadotropins (hMG) for ovulation induction and in all cases follicular aspiration was performed 32 to 34 hours after an injection of human chorionic gonadotropin (hCG). The concentrations of follicular-stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P), and 17 beta-estradiol (E2) in the follicular fluids (FF) were measured by radioimmunoassay (RIA). FSH concentration in the FF of the OCs group (15 women, 76 follicles) was significantly lower (2.1 mIU/mL) as compared to the FSH (15.9 mIU/mL) in the FF of the control group (20 women, 60 follicles). The LH FF concentrations after hCG injection were similar in the two groups. The E2/P ratio in the OCs group (9.6) was significantly lower than the E2/P ratio in the control group (20.6). OCs given to patients before induction of ovulation with hMG results in lower E2/P ratios and lower FSH concentration in the FF.

Chorionic Gonadotropin↗
PubMed1989

Amniotic fluid alpha-fetoprotein levels in the differential diagnosis of cystic hygroma.

In 7 second trimester pregnancies ultrasound (US) demonstrated cystic hygroma colli (CHC); amniocentesis was performed in 6 patients. In the 7th patient, because of oligohydramnios, the fluid for karyotype was aspirated from the CHC. Five pregnancies had been referred secondary to abnormalities on US and 2 others because of low maternal serum alpha-fetoprotein (MSAFP). Four karyotypes were abnormal (45,X;47,XX+21; 47,XY+21; 46,XX/45,X), and 3 had normal karyotypes. Amniotic fluid alpha-fetoprotein (AFAFP) was normal in 4 pregnancies and low in 2 (0.09 MOM, 0.41 MOM). Of 2 pregnancies with trisomy 21 one had been referred for low MSAFP. In 2 pregnancies with normal karyotypes, US findings at early gestational age (14-17 weeks) of small, nonseptated, bilateral CHC disappeared during pregnancy; these women delivered normal, term babies. Most prenatally diagnosed CHC are not in fetuses with Turner syndrome. With a normal karyotype and CHC as the only finding on early US in utero, normal neonatal survival is possible. AFAFP is not elevated in pregnancies with CHC. If AFAFP is elevated with a positive acetylcholinesterase, such results may suggest that the CHC was inadvertently aspirated.

Acetylcholinesterase↗
PubMed1988

Pregnancies following the interval double-transfer technique in an in vitro fertilization-embryo transfer program.

In 16 women undergoing IVF-ET, with more than four embryos available, two transfers were performed (24 hr apart), instead of one. The pregnancy rate was 25%, as compared with a pregnancy rate of 6.2% in 16 women having fewer than four embryos available and in whom one conventional transfer was performed. Since in our IVF-ET program, we do not freeze the extra embryos available, the purpose of the double transfer was to use all the embryos available and to improve the chances of finding the "implantation window" open. It is our feeling that multiple transfers may be beneficial to improve the pregnancy rate in an IVF-ET program without freezing facilities. However, a larger controlled clinical trial is necessary, in order to establish the advantages of multiple transfers in terms of pregnancy rate in comparison with the potential disadvantages.

Embryo Transfer↗
PubMed1987

The "forgotten" intrauterine device.

It is essential to ascertain that women who had an IUD inserted at some time have indeed had the device removed. It is also important to ensure that the whole IUD was removed and that no parts were left in the uterine cavity. This is especially true in cases of infertility and should be ascertained before invasive investigations such as hysterosalpingography or laparoscopy commence. An accurate history and ultrasonography can easily rule out a forgotten or fragmented IUD, thereby preventing considerable unnecessary suffering and expense.

Adult↗
PubMed1985

Continuous extraovular prostaglandin F2 alpha instillation for second-trimester pregnancy termination.

One hundred midtrimester pregnancy terminations were successfully induced with continuous extraovular infusion of prostaglandin F2 alpha (PGF2 alpha). The solution was infused into the extraovular space with a newly developed double-balloon catheter. The mean instillation abortion time was 12.9 h. Abortion was completed in 48% of the patients within 12 h, in 80% within 18 h, and in 96% within 24 h. The mean total dose of PGF2 alpha instilled was 12.4 mg/patient. Only four patients aborted after 24 h from the insertion of the catheter and instillation of the PGF2 alpha. Side effects were few. Thirteen patients (13%) had nausea and vomiting, and 14 (14%) had transient pyrexia (above 38 C). No major complications occurred. It appears that this method has a high success rate, good patient tolerance, and an acceptable safety factor with few minor side effects.

Abortifacient Agents↗
PubMed1983

Internal and external barriers to obtaining prenatal care.

Few studies have examined the reasons women do not obtain medical care during their pregnancies. A retrospective case review of 70 patients in a large metropolitan hospital who received minimal prenatal care examined demographic variables and reasons women gave for not seeking care. Data suggested there are both internal and external barriers to care. More women cited reasons including depression, denial, and fear than cited financial or transportation problems. Implications for social work intervention in the hospital and in the community are drawn from the data and discussed.

Adolescent↗
PubMed1982

Human fetal movement: spontaneous oscillations near one cycle per minute.

Spectral analysis of spontaneous fluctuations in human fetal movement revealed strong oscillations at frequencies between 0.24 and 0.90 cycle per minute, which are much higher than those of the cyclic alternation of quiet and active states in the fetus and neonate. Oscillations at frequencies up to 2.88 cycles per minute were also detected, but they were usually much weaker. The prominent peaks in the fetal movement spectra are in the frequency range of recently reported neonatal motor rhythms, and indicate the existence of a cyclic process controlling spontaneous motor output that oscillates near one cycle per minute and begins to function in utero.

Female↗
PubMed1982

The clustering of fetal heart rate changes and fetal movements in pregnancies between 20 and 30 weeks of gestation.

The temporal organization (nonrandomness) of fetal heart rate (FHR), fetal movement, and their association was evaluated in 20 normal pregnancies at 20 to 22 or 28 to 30 weeks of gestation with the use of external electronic fetal monitoring and statistical analysis with the runs test. At 20 to 22 weeks, significant clustering was found in one of 10 pregnancies for FHR change, two of 10 pregnancies for fetal movement, and one of 10 pregnancies for FHR changes associated with fetal movement. At 28 to 30 weeks, significant clustering was found in eight of 10 pregnancies for FHR change, eight of 10 pregnancies for fetal movement, and all 10 pregnancies of FHR change associated with fetal movement. There was significantly more clustering of FHR change, fetal movement, and FHR change associated with fetal movement at 28 to 30 weeks of gestation than at 20 to 22 weeks of gestation. Clustering of FHR changes was highly correlated with clustering of fetal movement.

Female↗
PubMed1982

The association between fetal heart rate patterns and fetal movements in pregnancies between 20 and 30 weeks' gestation.

The relationships between fetal heart rate (FHR) patterns and fetal movements (FM) were evaluated in 20 normal fetuses between 20 and 20 weeks' gestation. In 10 fetuses at 20 to 22 weeks' gestational age, 602 of the 620 observed FHR changes (97.1%) were decelerations. In this same group, most of the FHR changes (62.4%) were associated with FM. Similarly, 387 of 569 (68%) recorded FM between 20 and 22 weeks' gestation were associated with FHR changes. In a second group of fetuses between 28 and 30 weeks' gestation, in contrast to the less mature group, 227 of 670 FHR changes (33.9%) were decelerations. Among the remainder of the FHR changes, 240 (35.8%) were accelerations and 203 (30.3%) were accelerations with decelerations. As in the less mature group of fetuses, most of the FHR changes in these older fetuses were associated with FM (81.8%) and 548 of 611 (89.7%) recorded FM were associated with FHR changes. In summary, in normal pregnancy, FHR decelerations are common between 20 and 30 weeks' gestation. With advancing gestation, FHR decelerations are less commonly seen, and the frequency of acceleration and acceleration/deceleration patterns increases. The association between FHR and FM becomes stronger with advancing gestational age between 20 and 30 weeks. These findings suggest that the criteria for evaluating the health of the fetus before 30 weeks may be different from the criteria used later in pregnancy. Consequently, in the evaluation of low-birth weight fetuses between 20 and 30 weeks' gestation, new criteria for normal and abnormal nonstress monitoring tests must be developed.

Electrocardiography↗
PubMed1982

The change in fetal activity periods in diabetic and nondiabetic pregnancies.

Fetal active and quiet periods of behavioral activity were determined at 28 and 32 weeks' and 36 to 40 weeks' gestational age in insulin-dependent diabetic pregnancies and in normal pregnancies resulting in infants with weights appropriate for gestational age. Fetal active and quiet periods were based on observations of fetal movements and long-term fetal heart rate variability. The number of fetal active-quiet periods, the average duration of fetal quiet periods, and the average duration of fetal active periods were the three parameters evaluated. In the normal pregnancy groups, with increasing fetal gestational age from 28 to 32 weeks to 36 to 40 weeks there was an increase in the length of the active and quiet periods with fewer active-quiet cycles per hour. The fetuses of the diabetic women had findings similar to those of the normal group at 28 to 32 weeks; these findings were essentially unchanged at 36 to 40 weeks. These findings suggest delayed development of the active-quiet cycles in these diabetic pregnancies.

Behavior↗