Biomedical subjects

Y Soini

Publications and source records attributed to Y Soini.

129 records · Page 8Linked to original sources

PubMed1988

Widespread immunoreactivity for alpha-1-antichymotrypsin in different types of tumors.

The presence of alpha-1-antichymotrypsin (AACT) immunoreactivity was investigated in a broad range of different tumors. Because optimal AACT immunoreactivity of histiocytes was achieved by use of a protease pretreatment of paraffin sections, all tumors were studied by using pepsin treatment of the sections. In such conditions, more than 80% of different carcinomas, sarcomas, melanomas, and lymphomas were positive for AACT. The results indicate that AACT immunoreactivity is not specific for histiocytic tumors and therefore cannot be used as a histiocytic marker and to substantiate the concept of histiocytic nature of tumors, such as malignant fibrous histiocytoma. The concept of AACT as a histiocytic marker may be based on the fact that histiocytes, for some reason, stain more intensively for AACT, and immunoreactivity can also be found in them at unoptimal immunostaining conditions.

Histiocytes↗

PubMedDate not supplied

Matrix metalloproteinases 2 and 9 and their tissue inhibitors in low malignant potential ovarian tumors.

OBJECTIVES: This study aimed to analyze the expression of matrix metalloproteinases 2 (MMP-2) and 9 (MMP-9) and their tissue inhibitors TIMP-1 and TIMP-2 in low malignant potential (LMP) ovarian tumors and to compare these values with those recorded for benign and malignant ovarian neoplasms. METHODS: A total of 53 ovarian tumors (16 benign, 15 LMP and 22 malignant) were evaluated by immunohistochemistry for the expression of MMP-2, MMP-9, TIMP-1 and TIMP-2. RESULTS: MMP-2 expression was found in 56% of the benign, 40% of the LMP, and 90% of the malignant ovarian tumors (benign vs. malignant, p = 0.021; LMP vs. malignant, p = 0.002). The expression of MMP-9, TIMP-1 and TIMP-2 was lower in the benign and LMP tumors compared with the malignant ones. CONCLUSION: The data suggest that, in relation to the expression of MMP-2, MMP-9, TIMP-1 and TIMP-2, LMP ovarian tumors are more similar to benign than to malignant ovarian tumors.

Female↗

PubMedDate not supplied

High number of tumour-infiltrating lymphocytes is associated with apoptosis in non-small cell lung carcinoma.

AIM: To test whether the number of tumour-infiltrating mononuclear cells (MNC), namely T-lymphocytes (TIL) and, to a lesser degree, B-lymphocytes and macrophages, is associated with tumour cell apoptosis in non-small cell lung carcinoma (NSCLC). METHODS AND RESULTS: Eighty-four non-small cell lung tumours were analysed with specific antibodies and the extent of apoptosis was determined using 3'-end labelling of fragmented DNA (TUNEL). All parameters were determined from the same tumour areas. In general, adenocarcinomas showed a higher number of MNC than squamous cell carcinomas (p=0.04). The number of MNC increased concurrently with the grade of tumour, occurrence being highest in high grade (III) tumours (p=0.05). The number of apoptotic cells was significantly higher in tumours with a high number of CD3+ and CD8+ lymphocytes (p=0.01) and B-cells (p=0.05). Tumours showing abnormal p53 protein expression had a significantly lower count of CD8+ T-cells compared to p53-negative tumours (p=0.03). CONCLUSIONS: Our results showed an association between lymphocytic infiltration and extent of apoptosis in NSCLC, suggesting that an attempt to suppress the growth of transformed tumour cells exists even when the tumour has reached an advanced stage.

Apoptosis↗