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Biomedical subjects

Y Shimazono

Publications and source records attributed to Y Shimazono.

At least 37 records · Page 2Linked to original sources
PubMed1983

A comparison of the clinical effects of timiperone, a new butyrophenone derivative, and haloperidol on schizophrenia using a double-blind technique.

The efficacy and safety of timiperone, a new butyrophenone derivative, in schizophrenia as compared with haloperidol were assessed in a multi-clinic double-blind controlled study in a total of 206 patients. The patients were given timiperone (1.0 mg/tablet) or haloperidol (1.5 mg/tablet) in a daily dose of 1--3 tablets for the first day, then up to a maximum of 12 tablets depending on symptoms for 12 weeks. Timiperone was found to be significantly superior to haloperidol in the final global improvement rating and in the general usefulness rating. In the over-all safety rating there were no statistically significant differences between the two drug treatments. With regard to analysis by stratification timiperone was superior to haloperidol in improving abnormal experiences such as hallucination and delusion as well as deficiency of initiative and blunted affect. From these results it is considered that timiperone could be superior to haloperidol in the treatment of schizophrenia.

Adolescent↗
PubMed1981

Eye movement as an indicator of brain function.

The level of consciousness between the alert and drowsy states was classified into four stages (Alert, Resting I, Resting II, Drowsy) by studying three factors of the EEG patterns on 23 normal subjects. The eye movements recorded by electro-oculograph were divided into two groups, i.e. rapid eye movements (R type, r type) and slow eye movements (S type, s type). The occurrence of each type of eye movements was confirmed to change in close correspondence to the stages of consciousness. The eye movement on 43 cases with a disturbance of consciousness by metabolic disease were recorded longitudinally according to clinical states. The S type movements were predominantly observed in a state of clouding of consciousness, while the R type and R-S type were observed in a delirious state.

Adult↗
PubMed1980

Obituary..

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History, 20th Century↗
PubMed1976

A double-blind comparison of sulpiride with chlordiazepoxide in neurosis.

The therapeutic effectiveness of sulpiride on various types of neurosis was compared with that of chlordiazepoxide on a double-blind basis. Global improvement, effectiveness on various types of neurosis, and side effects were studied for a period of two weeks. The subjects consisted of 41 males and 32 females. Neurosis including borderline case and vegetative dystonia was divided into eight different subtypes comprising borderline, neurasthenic state, hypochondria, obsessive neurosis or phobia, depressive neurosis, anxiety neurosis, vegetative dystonia, and others. A newly devised matched-pair method of comparison was employed to achieve even distribution of the eight subtypes of neurosis between the two drug groups. As a result 40 patients fell in the sulpiride group and 33 patients in the chlordiazepoxide group. The backgrounds of the paired patients matched closely. The daily dose was uniformly 150 mg for sulpiride and 30 mg for chlordiazepoxide in the first week but was raised (or lowered in some cases) to 225 mg and 45 mg, respectively, in the second week according to severity. The rate of global improvement was 79% for the sulpiride group and 90% for chlordiazepoxide group, and the difference did not reach statistical significance. Improvement by manifestation (13 symptom items) and type of neurosis also matched. Side effects occurred at a rate of 28% (sulpiride group) and 30% (chlordiazepoxide group), and also matched closely in incidence and variety. The authors concluded that sulpiride in appropriate doses is useful in the treatment of neurosis without causing extrapyramidal side effects.

Chlordiazepoxide↗