[Use of analgesics and sedatives in the intensive care unit(ICU). I. Combined use of meperidine, pentazocine, and diazepam].
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Biomedical subjects
Publications and source records attributed to Y Shimada.
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Human liver specimens obtained by needle biopsy were extensively osmicated by the revised tannin-osmium method of MURAKAMI (1974) and cracked in air after critical point drying, to be observed in the scanning electron microscope. The fracture tended to occur along the membranous elements and exposed beautifully fractured faces of the hepatic cell. The nucleus of the hepatic cell was spherical. The nuclear pores were demonstrated as small pits 0.1 mu in diameter and their total occurrence in one nucleus was estimated to be 2,100. In the spongy framework resembling the endoplasmic reticulum, oval-shaped mitochondria and multivesicular tufts of the Golgi complex were observed. The nucleolus of the hepatic cell nucleus was noticed as a highlighted mass in the cloudy nucleoplasm.
A new peritoneoscopic classification of liver surface using a three digit code was developed. The first digit represents the lobular change from normal structure to nodules. The second digit represents the size of the nodule and the internodular distance. The third digit represents the pathological findings, such as inflammation, degeneration, necrosis or regeneration. Furthermore, peritoneoscopic findings of necrosis of lobular size around the portal vein and patchy markings of the liver were presented. These findings were the most prominent in the course of hepatitis progression to cirrhosis.
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A surviving patient with two rare types of abnormal eye movements, typical ocular bobbing and subsequently developed intermittent vertical oscillations of the eyes, is described, and a follow-up series of electro-oculographic recordings of these eye movements is analyzed. It is suggested that these two types of vertical eye movements might have a common pathophysiological background and the activity of remaining functional oculomotor pathways may play an important role in their occurrence.
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