Biomedical subjects

Y Seo

Publications and source records attributed to Y Seo.

204 records · Page 12Linked to original sources

PubMedDate not supplied

A newly established mouse model of peritoneal dissemination in human pancreatic cancer.

Tissue from a Suit-2 cell line derived from human pancreatic cancer was transplanted into the normal pancreas of Balb/c nu/nu mice using a physiological fibrin adhesive kit (Beriplast P). A minced tissue specimen (2-5 x 10(2) mg) was transplanted into normal pancreas in each nude mouse, and immediately thereafter 10 microliters of type A solution and 10 microliters of type Bsolution of Beriplast P were administered simultaneously at the transplanted area. The tumor tissue promptly adhered to the normal pancreas. Ten days after the implantation of cancer tissue, neovascularization had also already formed around the cancer tissue. The transplantation ratio of cancer tissue in normal pancreas was 100% (20/20). The capsule around the cancer tissue had not clearly formed. Twenty-one days after transplantation, the cancer cells were observed to be disseminated and closely fixed to the mesentery. The dissemination ratio of this cell line in the mouse mesentery was 85% (17/20) at 21 days after transplantation. This nude mouse model might thus be useful for investigating the development of human pancreatic cancer.

Animals↗

PubMedDate not supplied

Lentinan potentiates immunity and prolongs the survival time of some patients.

For the selection of patients responding well to lentinan, we performed two immunological analysis of patients. Flow cytometric analysis was obtained from peripheral blood lymphocytes; the patients who had greater than 2.5 ratio of [CD11(-) CD8(+)/CD11(+) CD8(+) after treatment]/[CD11(-) CD8(+)/CD11(+) CD8(+) before treatment] at 10 days after lentinan administration showed prolonged survival. The analysis of the- levels of soluble factors such as IL-6, sIL-6R, TNF-alpha, G-CSF, sICAM-1, IAP, and PGE2 and the decreasing levels of G-CSF, IL-6, and PGE2 after lentinan administration had a statistically significant correlation with the ratio of [CD4(+) CD29(+)/CD4(+) CD29(-) after treatment]/[(CD4(+) CD29(+)/CD4(+)CD29(-) before treatment]. The decrease in IL-6, G-CSF, and PGE2 levels after lentinan administration indicated an increase in immunine potential. From these results, we belive that patients with over 2.5-fold increase in [CD11(-) CD8(+)/CD11(+) CD8(+) after treatment]/[CD11(-) CD8(+)/CD11(+) CD8(+) before treatment] and showing a decrease in IL-6, G-CSF, and PGE2 levels after lentinan administration should continue treatment with lentinan for a long period.

Adjuvants, Immunologic↗

PubMedDate not supplied

Second primary extracolonic cancers in Japanese hereditary nonpolyposis colorectal cancer.

We examined the occurrence of second primary extracolonic cancers in 1,170 patients with nonpolyposis colorectal cancer who underwent a resection between 1972 and 1994. Such cancers occurred more often in cases with hereditary nonpolyposis colorectal cancer (HNPCC) than in those without (11.1% vs. 3.6%, P=0.0286). Five HNPCC cases developed 6 cancers in the stomach, endometrium, ovary, and ureter. The mean interval between the first and second operation was 66 months (range: 18-153). These findings thus indicate the importance of targetted surveillance for any second primary cancers in the upper gastrointestinal, female genital, or upper urologic tract, especially in HNPCC patients.

Adult↗

PubMedDate not supplied

Multiple primary colorectal and gastric carcinoma in Japan.

We investigated the occurrence of multiple primary colorectal and gastric cancer (MPCGC) in 1277 colorectal cancer patients between 1972 and 1996. MPCGC was found in 65 (5.1%). In the 28 synchronous cases, gastric or colorectal cancer was accidentally detected by pre-, intra-, or postoperative examinations. In 23 of the 37 metachronous cases, colorectal cancer developed on average 83 months after the operation for gastric cancer. In the other 14 cases, gastric cancer developed on average 70 months after the operation for colorectal cancer. Therefore, careful pre-, intra-, or postoperative examinations are strongly called for in order to not overlook the presence of colorectal or gastric lesions in MPCGC cases.

Adult↗

PubMedDate not supplied

The clinicopathological characteristics and outcome of patients with right colon cancer.

We compared the characteristics between the 281 cases with right colon cancer (RCC) and 438 cases with left colon cancer (LCC) who underwent a resection for the disease at our hospital between 1972 and 1995. The mean patient age was significantly higher for RCC than for LCC (62.5 years vs 60.4 years). The mean tumor size was also significantly larger in RCC than in LCC (6.1 cm vs 4.8 cm). The type of recurrence or survival was similar between RCC and LCC. Elderly patients were also found to be more likely to develop RCC than younger patients. This cancer often grows to a large size before being diagnosed. These findings, therefore, suggest the need for targeted examinations for the early detection of RCC, especially in the elderly.

Adenocarcinoma, Mucinous↗

PubMedDate not supplied

Sequential methothrextate and 5-fruororacil therapy for diffuse bone metastasis from gastric cancer.

We herein present a case of diffuse bone metastasis from early gastric cancer with disseminated intravascular coagulation (DIC) in a 40-year old man, who had undergone a curative gastrectomy and had no evidence of recurrence for five years after surgery. The patient was treated with an intravenous administration of sequential methothrexate (MTX) and 5-fluorouracil (5-FU), and demonstrated a favorable clinical course without any severe pain. Despite the fact that the presence of diffuse bone metastasis from gastric cancer plus hematologic disorders tends to indicate a significantly poor prognosis, the patient survived for a relatively long period (11 months) following chemotherapy. We thus conclude that MTX/5-FU sequential therapy seems to be a clinically useful regimen to improve both the symptoms and survival for cases of diffuse bone metastasis from gastric cancer.

Adult↗