[Problems of the localized elevation of the gastric mucosa and its relation to cancer].
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Adenocarcinoma↗
Biomedical subjects
Y Sekiguchi
Publications and source records attributed to Y Sekiguchi.
A new coastal marine ecosystem model study coupled with hydrodynamics and tidal flat ecosystem effect.
A new coastal marine ecosystem model was developed, which was composed of pelagic and benthic ecosystems, and was applied to Mikawa Bay, Japan. This model deals with variations of biochemical and physical interactions among dissolved oxygen and C-N-P species (composition formed out of carbon, nitrogen and phosphorus elements) so that it resolves the flux dynamics of carbon, nitrogen, phosphorus and oxygen elements. The physical and biochemical mechanism figured in this model is constructed for the purpose of simulating the estuarine lower trophic ecosystem, in areas where the sea was too deep for light to reach the sea-bottom. As a result of coupling the benthic with pelagic system, the effect of process of sedimentation and nutrient diffusion back to the pelagic system could be indicated. In addition, by implementing the tidal flat ecosystem model's calculation result, the integrated model can include the effect of water purification in tidal flats where the light can reach the sea-bottom, and where seaweed, sea grass and benthic algae exist. In this study, the model indicates that oxygen-depleted water exists at the sea-bottom especially in summer mainly caused by an increase of oxygen consumption in the benthic system and a decrease of the vertical mixing water process. Furthermore, by comparing the case--with the tidal flat ecosystem model and the case without it, the effect of water purification of tidal flat estuaries was indicated. From the viewpoint of a short time scale, the tidal flat has the potential to restrict red tide (rapid increase of phytoplankton), and from the viewpoint of a long time scale, it restricts the sedimentation of detritus. Restricting the sedimentation prevents oxygen-depleted water occurring in the coastal marine system of Mikawa Bay.
Ecosystem↗
Immunohistochemical analysis of platelet-derived growth factor-B expression in myocardial tissues in hypertrophic cardiomyopathy.
Intimal and/or medial hyperplasia of intramyocardial small vessels is thought to be one of the causes of myocardial ischemia in hypertrophic cardiomyopathy (HCM). However, the pathogenesis of such vascular lesions in HCM is not yet known. To evaluate the pathogenic role of platelet-derived growth factor (PDGF-B) and basic fibroblast growth factor (b-FGF), which have a potential to induce cellular and molecular changes observed in the vessels in HCM, we examined the expression of these molecules and PDGF receptors in cardiac tissues from six patients with HCM and seven controls using immunohistochemistry. The percentage of PDGF-B positive cells in the myocyte population in HCM was significantly higher than that in controls (52.6 +/- 16.2 (mean +/- SD) vs. 21.6 +/- 9.6, p < 0.01). PDGF-B was also observed in vascular regions in HCM (61.1 +/- 25.5% of arterioles) but not in controls. There were no significant differences in the expression of b-FGF and PDGF receptors in the myocyte and non-myocyte populations and the vascular regions between the HCM and control groups. Our study revealed that the expression of PDGF-B protein was up-regulated in HCM, suggesting the contribution of this molecule to the development of intramyocardial vasculopathy.
Adolescent↗
Treatment of sick sinus syndrome with permanent cardiac pacemaker. (Sick sinus syndrome and artificial pacemaker).
Twenty nine patients with sick sinus syndrome were treated from November, 1972 through July, 1976. Six cases had sinus bradycardia, 14 cases had sinoatrial block/sinus arrest and 9 cases had bradycardia-tachycardia syndrome. Twenty five patients received the implantation pacemaker with good result. There was found that an adequate pacing of the heart was effective for the control of the attack of tachyarrhythmia in the case with bradycardia-tachycardia syndrome.
Adolescent↗