Biomedical subjects
Y Sakurai
Publications and source records attributed to Y Sakurai.
[Simple heat exchanger designed for disposable sheet oxygenators].
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[Application of tumor cell culture--screening of antineoplastic drugs].
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Anticancer activities of methanesulfonic acid esters of aminoglycols against mouse leukemia L-1210.
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Structure of curdione.
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Biochemical changes in tumor cells caused by antitumor agents. I. Effects of several antitumor agents on NAD content and NAD-glycohydrolase activity in Yoshida sarcoma cells and rat liver.
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Primary mass culture of Yoshida sarcoma and rat ascites hepatomas.
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Increase of glycogen and oligosaccharide contents in ascites tumor cells by action of nitrogen mustard.
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Biochemical changes in tumor cells caused by antitumor agents. II. Effect of several antitumor agents in vivo and in vitro on beta-glucuronidase and two other lysosomal enzymes of Yoshida sarcoma cells.
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Isolation and characterization of nitrogen mustard-sensitive cells from a nitrogen mustard-resistant subline of Yoshida sarcoma.
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Carcinostatic activity of several new derivatives of sulfonic acid esters of some aminoglycols.
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Structure of curcumol.
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Preparation of derivatives of nitrogen mustard having structure of alpha-amino acid amide.
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Inhibition of tumor growth by new sulfonic acid esters of aminoglycols.
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A new alkylating antitumor agent effective on experimental tumors resistant to nitrogen mustard.
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Studies on the artificial heart driven with controlled gas pressure device on the pressure generator for universal use.
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Cell-assembly coding in several memory processes.
The present paper discusses why the cell assembly, i.e., an ensemble population of neurons with flexible functional connections, is a tenable view of the basic code for information processes in the brain. The main properties indicating the reality of cell-assembly coding are neurons overlaps among different assemblies and connection dynamics within and among the assemblies. The former can be detected as multiple functions of individual neurons in processing different kinds of information. Individual neurons appear to be involved in multiple information processes. The latter can be detected as changes of functional synaptic connections in processing different kinds of information. Correlations of activity among some of the recorded neurons appear to change in multiple information processes. Recent experiments have compared several different memory processes (tasks) and detected these two main properties, indicating cell-assembly coding of memory in the working brain. The first experiment compared different types of processing of identical stimuli, i.e., working memory and reference memory of auditory stimuli. The second experiment compared identical processes of different types of stimuli, i.e., discriminations of simple auditory, simple visual, and configural auditory-visual stimuli. The third experiment compared identical processes of different types of stimuli with or without temporal processing of stimuli, i.e., discriminations of elemental auditory, configural auditory-visual, and sequential auditory-visual stimuli. Some possible features of the cell-assembly coding, especially "dual coding" by individual neurons and cell assemblies, are discussed for future experimental approaches.