Mechanism of racemization in the reaction of 4-methylcyclohexylidenemethyliodonium salt with sulfonate ions: formation of intermediate cycloheptyne.
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Biomedical subjects
Publications and source records attributed to Y Sakanishi.
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To our knowledge, this report represents the first confirmed case in Japan of a 15-year-old boy with acute lymphoblastic leukemia (ALL).L3 with hand-mirror cells (HMC) in the bone marrow. HMC lymphoid leukemia is an unusual variant of ALL in which the bone marrow lymphoblasts manifest distinctive hand-mirror morphologic features. HMC lymphoblast is characterized by an asymmetric foot-like cytoplasmic process that extends from the portion of the cell, thus giving it the light-microscopic appearance responsible for its name. Besides ALL, HMC has been reported in acute myeloblastic leukemia (AML), blastic crisis of chronic myelogenous leukemia, non-Hodgkin's lymphoma, and infectious mononucleosis. HMC has been reported to be prevalent in ALL.L1 and L2 as compared with L3.
We used fluorophotometry and pachymetry to examine the early postoperative effects on the anterior segment of the eye after posterior chamber intraocular lens implantation combined with extracapsular cataract extraction as compared to extra-capsular cataract extraction alone. Fluorophotometry was performed by a method of intravenous injection of fluorescein solution (1 mg/kg of body weight) on the 6th postoperative day. We calculated the value of the Fa/Fp ratio, where Fa and Fp were fluorescein concentration in the aqueous and the plasma ultrafiltrate, respectively, and treated it as an index of the blood-aqueous barrier function. Also, we optically measured the corneal thickness and the anterior chamber depth. There were no significant differences between the values of the Fa/Fp ratio and corneal thickness in the two groups. The anterior chamber depth in the pseudophakic eyes (2.89 +/- 0.48 mm, mean +/- SD) differed significantly from that of the eyes undergoing extracapsular cataract extraction alone (3.10 +/- 0.51, P less than 0.001). In the cases of posterior chamber lens implantation, the postoperative value of the Fa/Fp ratio in the intact fellow eyes showed a significant increase compared to the preoperative value in the same eyes (1.2 +/- 0.8 times, P less than 0.05). We conclude that the effects on the anterior segment barrier function of extracapsular lens extraction followed by posterior chamber intraocular lens implantation are not significantly different from those of extracapsular lens extraction alone.
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We used fluorophotometry and pachymetry to examine the longer-term (more than three months) postoperative effects in the anterior segment of extracapsular lens extraction with and without posterior chamber intraocular lens implantation. Fluorophotometry was performed after oral administration of fluorescein solution (5 mg/kg of body weight under fasting condition). We calculated the corneal endothelial transfer coefficient, fluorescein distribution ratio, aqueous transfer coefficient in reference to chamber volume, and loss coefficient and measured corneal thickness with a modified pachymeter. There were no significant differences between the values for corneal endothelial transfer coefficient and corneal thickness in the two groups of surgically treated eyes combined vs the intact fellow eyes. The aqueous transfer coefficient and loss coefficient values were not significantly different between the two surgically treated groups. Anterior chamber depth did not differ significantly between the two surgical groups, but the value for the two groups combined (3.79 mm) did differ significantly from that of the fellow eyes (2.87 mm) (P less than .005). We concluded that endothelial function recovers three months after extracapsular lens extraction with or without posterior chamber intraocular lens implantation, and that the effects of intraocular lens implantation on anterior segment barrier functions are not significantly different from those of extracapsular lens extraction alone.
A total of 100 eyes underwent planned extracapsular cataract extraction and were followed more than three months with a mean follow-up period of 12 +/- 8 months. After-cataract was found in 72 eyes. The after-cataract was classified by slit-lamp microscopy into two types, the remnant type and the proliferative type. The former type was due to remains of the lens materials and was present immediately after the surgery: this type was divided into veil-like and Soemmering forms. The proliferative type developed after a period following surgery and was divided into fibrous form and Elschnig form. The fibrous form was thought to be due to fibrous proliferation of the lens epithelial cells, since it was seen at or to originate from the sites of adhesion of the anterior and posterior capsules. The Elschnig form consisted of Elschnig's pearls and was divided into progressive and localized subforms. The former subform was seen more frequently in young patients than the latter subform. The incidences of the above types and forms of the after-cataract were determined. Impairment of the visual acuity due to after-cataract was seen in the proliferative type and was found in 7 eyes. A fluorophotometric study to evaluate the function of the blood-aqueous barrier was carried out in 7 patients with the presence of after-cataract and in 11 patients with no or subtle after-cataract. No difference was found in the barrier function between the two groups.
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