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Biomedical subjects

Y Sakamoto

Publications and source records attributed to Y Sakamoto.

At least 775 records · Page 43Linked to original sources
PubMed1979

Alteration in binding of dexamethasone to glucocorticoid receptors in regenerating rat liver after partial hepatectomy.

Changes in binding of dexamethasone (9 alpha-fluoro-11 beta, 17 alpha, 21-trihydroxy-16 alpha-methylpregna-1,4-diene-3,20-dione) to its receptors in regenerating rat liver after 70% hepatectomy were examined. Specific receptors for dexamethasone in the liver remnants of adrenalectomized rats decreased significantly during the period of DNA synthesis after 70% hepatectomy; then, they increased to above the control values between Days 4 and 7 after partial hepatectomy and subsequently returned to the control values. During the period of DNA synthesis, decreased binding was observed in partially hepatectomized rats with or without adrenals, but later enhanced binding was not prominent in rats with adrenals.

Adrenal Glands↗
PubMed1979

Postoperative evaluation of the exocrine function of the pancreas after pancreaticoduodenectomy.

The exocrine function of the residual pancreas of eight patients who underwent pancreaticoduodenectomy was studied with the 131I-triolein absorption test and by 75Se-selenomethionine scintiscanning. In six patients, a pancreaticojejunostomy was performed, while in the other two patients, the pancreatic duct of the residual pancreas was ligated. The fecal 131I-triolein excretory rate in the duct ligation group was more than 50 per cent, while, in all but one patient in the duct anastomosis group, it was less than 10 per cent. Pancreatic scintiscanning in the duct ligation group was negative before and after operation. All of the patients with anastomosis of the duct had an image of the pancreas before operation. However, postoperatively, scintiscanning of the pancreas was negative in two patients and became negative late in the postoperative period in four others without any decline of fat absorption. The cause for this postoperative change in scintiscanning of the pancreas and the discrepancy of this finding with that obtained with the 131I-triolein absorption test remains to be studied.

Duodenum↗
PubMed1979

Type C particles in culture of human glioblastoma cells.

A long-term cell culture of human glioblastoma was investigated microscopically, virologically, and biochemically. Reverse transcriptase activity was detected in cultured human glioblastoma cells. 3H uridine was incorporated into particles of buoyant density at 1.07 g/ml (Ficoll) which is equal to that of Oncorna virus particles, but 3H thymidine was not incorporated at all. Furthermore, reverse transcriptase activity was also demonstrated with the particles, suggesting that the cultured human glioblastoma cells were producing type C Oncorna virus. Ultrastructural observations of cell culture of glioblastoma showed type C virus particles in cisternae and culture medium. Budding of the virus was also seen on the surface of the cell. The mean diameter of the particles was approximately 100 nm. Ca. 1.1 nm of spikes protruded from the envelope. Both types of virions were observed, i.e. the doughnut-shaped type form and the solid circular form.

Adolescent↗
PubMed1978

Long-term prognosis on recurrence of seizures among children with epilepsy after drug withdrawal-elimination.

The long-term prognosis of 110 children after withdrawal-elimination of the drugs on the basis of our rigid criteria was analyzed. The 12 cases (10.9%) of 110 patients experienced recurrences, which occurred between three months to three years after drug elimination, but there were no recurrences later than three years to 10 years after drug elimination. The asymmetry in the EEG during the first two to three years after drug elimination appeared in 6.4% and seizure discharge appeared in 17.1%. But no asymmetry nor seizure discharge was found in EEG later than three years after drug elimination.

Anticonvulsants↗
PubMed1978

Restoration by adrenalectomy of weight and binding capacity of glucorcorticoid receptors of the thymus in AH 130 tumor-bearing rats.

The binding capacity of specific receptors for dexamethasone (11beta,17alpha,21-trihydroxy-9alpha-fluoro-16alpha-methyl-1,4-pregnadiene-3,20-dione) in the cytoplasm of the thymus of rats bearing AH 130 (solid-type) tumors decreased significantly during tumor growth. Adrenalectomy restored the binding capacity of the glucocorticoid receptors and the weight of the thymus to nearly the normal values in rats bearing tumors. The affinity of these receptors for dexamethasone was very low in rats bearing tumors, but it was also restored to nearly the normal value by adrenalectomy.

Adrenal Glands↗