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Biomedical subjects

Y S Lu

Publications and source records attributed to Y S Lu.

82 records · Page 5Linked to original sources
PubMed1973

The effect of aspirin on sickling and oxygen affinity of erythrocytes.

The recent suggestion that the administration of aspirin might be useful in the treatment of sickle-cell anemia has been further studied and found to be without basis. After incubation with aspirin, sickle-cell erythrocytes are not inhibited from sickling after deoxygenation. In addition, although aspirin does transfer the acetyl group to hemoglobin both in vitro and in vivo, in our experiments the reaction does not result in any alteration in the oxygen equilibrium of either intact erythrocytes or hemoglobin in solution. Furthermore, patients maintained on long-term aspirin administration also showed no shift in the oxygen affinity of their blood.

Anemia, Sickle Cell↗
PubMedDate not supplied

Effects of IgY antibody on the development of Marek's disease.

The effects of passive immunization with immunoglobulin Y (IgY) on the pathogenesis of Marek's disease (MD) were examined in an experimental line of White Leghorn chickens highly susceptible to MD. Purified IgY with anti-MDV antibody activity, when injected into chicks, delayed the development of MDV viremia and lesions until 9 days postinoculation (PI) with Marek's disease virus (MDV). The blastogenic response of spleen cells to concanavallin-A was depressed at 6 days PI in the birds without passive immunization, whereas it was not totally depressed until 17 days in birds passively immunized with IgY anti-MDV antibody.

Animals↗
PubMedDate not supplied

Infectious bill atrophy syndrome caused by parvovirus in a co-outbreak with duck viral hepatitis in ducklings in Taiwan.

In October 1989, an epizootic duckling disease with high mortality occurred in Taiwan. The disease was characterized by droopiness, inappetence, ataxia, ruffled feathers, and watery diarrhea. Affected ducklings were lame, were unable to stand, showed opisthotonos, and often died 3 or 4 days after the onset of the disease. Tolerant maturing ducklings displayed atrophic upper bills with a protruding tongue and became stunted as they reached maturity. No diagnostic histopathologic lesions were found in these ducklings. Fourteen parvovirus isolates, 33 duck viral hepatitis virus (DVHV) isolates, two adenovirus isolates, and two reovirus isolates were obtained and identified from more than 500 sick ducklings in the epizootic. The epizootic was diagnosed as a co-outbreak of duck parvovirus infections and duck viral hepatitis. The high mortality in ducklings and the bill atrophy syndrome were reproduced in ducklings by inoculating the parvovirus isolates alone. The epizootic was controlled by an emergency immunization program of ducklings with sera collected from recovered ducks or a bivalent inactivated vaccine composed of local DVHV and parvovirus isolates.

Animals↗