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Biomedical subjects

Y Rusecki

Publications and source records attributed to Y Rusecki.

14 recordsLinked to original sources
PubMed1993

Skin surface pH in intertriginous areas in NIDDM patients. Possible correlation to candidal intertrigo.

OBJECTIVE: To compare skin surface pH and moisture in intertriginous areas in diabetic patients and healthy control subjects and to study the relationship between these parameters and candidal infection. RESEARCH DESIGN AND METHODS: We measured the skin surface pH and moisture in the axillary, inframammary, inguinal, and forearm skin with a pH meter with a flat-glass electrode and skin corneometer. The subjects were 50 NIDDM patients from the diabetic outpatient clinic at Beilinson Medical Center, Petah Tiqva, Israel, and 40 healthy control subjects from hospital personnel. The main outcome measures were skin surface pH, skin moisture, and skin culture for Candida. RESULTS: Skin pH in the inguinal and axillary regions was significantly higher in diabetic patients compared with healthy control subjects (P < 0.0001), whereas no difference was noted in the forearm. In the inframammary region, diabetic women had significantly higher pH than nondiabetic women (P < 0.01). No difference was noted in men in this region. Six patients (12%) had candidal infection in intertriginous areas. CONCLUSIONS: Our study indicates that in intertriginous regions, skin surface pH of diabetic patients is significantly higher than in normal control subjects and implies the significance of skin pH as a possible factor promoting host susceptibility to skin candidal infection.

Adult↗
PubMed1992

Prevalence of minor congenital anomalies in newborns of diabetic mothers.

Minor congenital anomalies (MCA) were assessed in the offspring of 802 gestational diabetic mothers, 117 pre-gestational diabetic mothers, and 380 offspring born to normal mothers. The prevalence of infants with MCA ranged between 19.4% and 20.5% in the three groups without any significant difference between them. There was no correlation between the prevalence and type of MCA and the severity of the diabetic state. Neither was there any correlation between the prevalence or type of MCA and the appearance or type of major congenital anomalies.

Abnormalities, Multiple↗
PubMed1989

The protracted effect of o,p'-DDD in Cushing's disease and its impact on adrenal morphogenesis of young human embryo.

We hereby present a patient with Cushing's disease who became pregnant while being treated with o,p'-DDD and underwent a therapeutic abortion in view of the known embryotoxicity and placental transfer of this drug. Biopsy of adipose tissue in this patient showed it to be the storage site of considerable quantities of o,p'-DDD. Serum levels of o,p'-DDD determined in this patient initially four months after withdrawal of treatment and in another similar case three months after withdrawal were about 20 times higher than those found in untreated patients and reached control values only about 20 months later. Repeated evaluation of plasma and urinary free cortisol failed to reveal any correlation with the serum levels of o,p'-DDD, suggesting that the drug blood values cannot be used as a reliable indicator of the therapeutic effect on the adrenal gland. The histopathological examination of the embryo, aged about 42 days, revealed a dysmorphogenic event in the cortical primordia characterized by pycnotic sympathoblasts. It is suggested that such a toxic effect of o,p'-DDD on the embryonic cortical cells may act indirectly, affecting the viability of the migrating sympathoblasts.

Abortion, Therapeutic↗
PubMed1988

Prevalence of diabetes in Israel. Epidemiologic survey.

A survey of 4660 Israeli adults aged 30-65 yr revealed an overall diabetes prevalence of 4.1%. Prevalence was slightly lower in women (3.5%) than in men (4.3%), rose with age, and was highest in the group greater than 60 yr old (10.3%). In approximately 40% of the diabetic subjects, the diagnosis of diabetes was made as a result of the screening program. Association with a family history of diabetes, obesity, and the presence of other diseases was greater in diabetic than in nondiabetic subjects. The prevalence of diabetes differed among different segments of the survey population when classified according to country of origin, being lowest in African and Asian (1.2%), intermediate in American and European (4.9%), and highest in Israeli born (5.5%); this order of prevalence is the reverse of that reported in earlier surveys. The results indicate that the overall diabetes prevalence in Israel, and that within the European- and American-born segment, is comparable to that reported in other westernized societies. The findings also suggest that environmental factors contribute to the phenotypic expression of the non-insulin-dependent genotype(s) but that the influence of such factors varies with different genetic backgrounds.

Adult↗
PubMed1988

High prevalence of diabetes in young adult Ethiopian immigrants to Israel.

We performed oral glucose tolerance tests in 158 Ethiopian immigrants to Israel. The subjects were less than 30 yr of age, had lived in Israel less than or equal to 4 yr, and originated from villages in the Gondar and Ambovar regions of Ethiopia. Most had been subjected to famine conditions in Ethiopia and/or extreme hardship in Sudan before or during immigration. All were lean. They revealed a profound change in dietary habits since their arrival in Israel, with consumption of large amounts of refined carbohydrate in place of spicy stews and injura (Ethiopian pita) that had constituted dietary staples in better times in Ethiopia. According to National Diabetes Data Group criteria, 14 (8.9%) of the subjects had diabetes, and another 14 (8.9%) had impaired glucose tolerance. In addition, 13 subjects had a dramatic increase in capillary blood glucose levels (greater than 300 mg/dl) 1 h after ingestion of 75 g glucose, despite fasting and 2-h values well within the normal range, and they complained of associated symptoms during the 1st h of testing. Eleven of 137 men and 3 of 21 women had diabetes; 7 (5.1%) of the men and 7 (33%) of the women had impaired glucose tolerance. These results indicate a high prevalence of diabetes among young adult Ethiopian immigrants of relatively short residency in Israel, for which the factors responsible warrant further investigation.

Adolescent↗
PubMed1985

Glucose tolerance test in Israeli pregnant women.

An oral glucose tolerance test (GTT) was performed in 1,055 healthy Israeli women at various stages of pregnancy. The whole venous blood glucose levels were higher in Israeli pregnant women than in American pregnant women. By adding 2 SD to the mean values, the upper limits of the oral GTT in the Israeli pregnant women were higher than the corresponding limits in American pregnant women. According to our results, 2.7% of Israeli pregnant women have gestational diabetes. However, if American standards are used, then 3.7% of our population would be considered to have gestational diabetes. Each population should be evaluated, therefore, according to its specific standards. The mean +/- 2 SD glucose levels of the GTT in pregnant women at age greater than or equal to 30 years were higher than those of the entire population of pregnant women. It is suggested, therefore, that the GTT of each pregnant woman should be considered according to her age-group.

Adolescent↗
PubMed1983

Evidence for a therapeutic effect of dl-propranolol in benign and malignant insulinoma: report of three cases.

Two patients suffering from benign and one patient suffering from malignant insulinoma experienced frequent incapacitating hypoglycemic attacks which did not respond to treatment with streptozotocin, diazoxide and/or diphenylhydantoin. Dl-propranolol, in dosages ranging from 30-240 mg/day, successfully abolished the symptoms of hypoglycemia, prevented recurrent hypoglycemic attacks, and normalized blood glucose levels concomitant with a reduction in pulse rate to 60/min. The main mechanism of the drug's effect seems to be the suppression of insulin release. However, other mechanisms may be involved such as increased peripheral insulin resistance. No side effects of treatment with dl-propranolol were noted. In patients suffering from insulinoma who are refractory to other forms of treatment, and for those who need symptomatic relief before surgery, dl-propranolol may play an important therapeutic role.

Adenoma, Islet Cell↗
PubMed1981

Successful treatment of polycystic ovary syndrome with spironolactone or bromocriptine.

Marked improvement in the severe hypertension (250/150 mmHg) and hirsutism of a patient suffering from polycystic ovary syndrome was quickly achieved by the use of spironolactone 200 mg per day. Substitution of spironolactone with bromocriptine induced further amelioration of these symptoms and renewal of ovulatory cycles. These drugs may afford another mode of therapy in patients with polycystic ovary syndrome.

Adult↗
PubMedDate not supplied

Prevalence of congenital anomalies and neonatal complications in the offspring of diabetic mothers in Israel.

The prevalence of diabetes in pregnancy and its fetal and perinatal consequences in a large population of Israeli pregnant women during the last decade are presented. The study population consisted of 878 gestational diabetic women, 132 pre-gestational diabetic women, and 380 healthy pregnant women who served as controls. Minor congenital anomalies ranging between 19.4 and 20.5%, major congenital anomalies between 1.80 and 6.82%, and neonatal complications, such as macrosomia (5.6-25.0%), hypoglycemia (0.9-7.8%), hyperbilirubinemia (8.2-16.7%), hypocalcemia (2.7-5.5%) and polycythemia (3.8-13.3%), were observed in the study population. Despite meticulous maternal glucose control, we could not entirely eliminate fetal and neonatal complications. The definition of the normal and abnormal fetal intrauterine metabolic environment remains to be elucidated.

Congenital Abnormalities↗