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Biomedical subjects

Y Pennec

Publications and source records attributed to Y Pennec.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Rheumatic manifestations in the presence of antibodies to Yersinia pseudotuberculosis. Apropos of 4 cases].

Rheumatic manifestations due to Yersinia pseudotuberculosis are apparently rare. We report four personal observations, including one of a patient with Reiter disease and significant titres of antibodies to Yersinia pseudotuberculosis. In all four patients a non-specific syndrome, with fever and digestive symptoms, preceded the onset of joint disease. Both peripheral and axial joints were affected. One patient had HLA B27; the brother of another patient had spondyloarthropathy with HLA B27. Stool cultures were negative but they were all done at least three months after the acute episode. These rheumatic manifestations have many features in common with those described in Yersinia enterocolitica infections. Studies of larger series could improve our knowledge of the part played by the patients' constitution and widen the scope of reactive arthritis.

Adult↗
PubMed1982

[Spontaneous peritonitis in a cirrhotic patient (author's transl)].

A case of spontaneous peritonitis in a cirrhotic patient is reported. Because of marked peritoneal and hemodynamic signs, exploratory laparotomy was decided on. Such cases of spontaneous peritonitis, which mimick surgical affections, are very uncommon. Onset is usually insidious with increasing hepatic fluid as the only sign. Bacteriologic examination of the peritoneal fluid is often negative. Diagnosis should be considered if cytology shows more than 75 polynuclear leukocytes per mm. When bacteriology is negative, association of an aminoside with penicillin G and metronidazole seems to be the most satisfactory combination.

Adult↗
PubMed1982

Folic acid deficiency and neutrophil dysfunction.

Polymorphonuclear leukocyte functions were studied in 92 patients with protein-calorie malnutrition. Serum folic acid levels were higher than 3 ng/ml in 38 patients and 3 ng/ml or less in 54 patients. Significant differences were found between these two groups of patients with regard to phagocytosis (81.5 +/- 1.9 versus 69.2 +/- 2.0 percent, p less than 0.001) and bactericidal ability (90.6 +/- 1.1 versus 84.5 +/- 2.3 percent, p less than 0.05). Correction of folic acid deficiency in 22 patients was associated with recovery of normal phagocytosis (p less than 0.001) but not bactericidal function. Adding folic acid to the serum of eight patients also restored normal phagocytic function (p less than 0.001). A correlation was found in vivo and in vitro between changes over time in folic acid levels and in phagocytosis.

Blood Bactericidal Activity↗
PubMed1982

Comparison of the manifestations of acute sarcoid arthritis with and without erythema nodosum. Immunopathogenic significance.

This retrospective study deals with the clinical, radiological and biological data of 16 patients suffering from sarcoid arthritis with (n = 11) and without (n = 5) erythema nodosum (EN). The average age and sex distribution were the same and we failed to demonstrate any significant difference between the two groups. However, it is worth noting that the average number of the joints affected was less in a patient with (3.0) than in a patient without EN (4.8) and that persistence of polyalgias was associated with EN. Nevertheless, one may assume that the current series corroborates the common immunological pathophysiology of these two pictures of sarcoid arthritis.

Adult↗
PubMed1982

[Ocular herpes. Correlations between subpopulations of T lymphocytes and clinical manifestations?].

Herpes simplex virus can affect the cornea in many ways, the main differences concerning the evolutive stage and the severity. Using the rosettes technique, we have tried to know if the study of the T lymphocytes subsets may give some help in foreseeing the risk of stromal or recurrent keratitis. Peripheral lymphocytes and T lymphocytes subsets: total E, E-active, autologous rosettes forming cells (E, E-act., auto-RFC) were studied among 60 patients with different clinical manifestations of herpetic keratitis: i.e. 27 epithelial and 23 stromal ones, 20 primary and 40 recurrent keratitis. Two groups of patients were found to have decreased levels of one T lymphocytes subset: the stromal ones with the most serious prognosis had above all a E-act--RFC decrease (16,5 +/- 8,5% vs 24,1 +/- 4,7 for the controls, p 0,001); the recurrent ones had above all a E-RFC decrease (53,6 +/- 6,4% vs 63,7 +/- 8,7 for the controls, p less than 0,001). So the most severe herpetic keratitis: recurrent and stromal ones seem to have cellular immunity abnormalities that are not found in the superficial or primary keratitis.

Adolescent↗
PubMed1982

Analysis of criteria in staging in multiple myeloma.

One hundred and thirty patients suffering from multiple myeloma were reviewed for retrospective study of their classification according to Durie and Salmon's staging system. No significant difference was found in survival between patients in stage I, II and III. Since then, each criterion developed by Durie and Salmon was evaluated separately. Only the Hb level showed a significant influence; a Hb level under 8.5 g/dl or corrected calcaemia above 3 mmol/l were never found separately. When survival according to the number of criteria was considered there was no difference. These findings agree with the well-founded classification of Durie and Salmon but the real importance of each criteria is questionable.

Calcium↗
PubMed1981

[Myasthenia gravis and asymptomatic monoclonal gammapathy. Detection of autoantibody activity of the monoclonal immunoglobulin].

Simultaneous occurrence of "myasthenia gravis" and monoclonal "asymptomatic" gammapathy has been observed in a 83 years old patient. Antistriated muscle antibodies could be detected at a level of 1/1,000 but no antiacetylcholine receptors antibodies. The antibody activity is located both in the monoclonal IgG kappa and in the polyclonal IgG. This case illustrates the frequent occurrence of several auto-immune disorders in a same patient.

Aged↗
PubMed1981

[Waldenström's macroglobulinemia and peripheral amyloid neuropathy (author's transl)].

A 77-year-old man was diagnosed as having Waldenström's macroglobulinemia sex years after developing a sensory-motor neuropathy of the four limbs. The amyloid nature of the neuropathy was confirmed after biopsy of a peripheral nerve. The pathogenesis of the amyloidosis occurring during the course of dysglobulinemias is discussed, and those dysglobulinemias associated with non-amyloid neuropathies briefly described.

Aged↗
PubMed1980

[Articular chondrocalcinosis revealed by acute cervical symptoms simulating meningitis (author's transl)].

Four cases of acute cervical pain with high fever and important stiffness of the cervical spine, leading to study the cerebrospinal fluid in emergency, are reported. All cases had elevated erythrocyte sedimentation rate. Recovery was obtained in all cases in a few days without treatment. The cerebrospinal fluid was normal in the three cases studied. In three patients the roentgenograms demonstrated calcified cervical cartilages, mainly in the atlas-axis joint, and osteo arthritis-like arthropathies. This syndrome, simulating meningitis revealed the calcium pyrophosphatecrystal deposition disease in the four cases. Crystal-induced arthritis of the cervical spine is suggested but not demonstrated.

Acute Disease↗
PubMedDate not supplied

[Is the target of anti-cardiolipin antibodies the same in Gougerot-Sjögren syndrome and lupus erythematosus disseminatus?].

Forty-seven patients were diagnosed as having systemic lupus erythematosus (SLE) and 34 patients primary Sjögren's syndrome (SS); 30 controls were also studied. Anti cardiolipin (CL), anti double-stranded DNA (ds DNA) and anti single-stranded DNA (ss DNA) antibodies were determined by the enzyme-linked immunosorbent assay. Elevated anti-CL antibody levels were detected in 47.8 p. 100 (n = 46) of patients with SLE and in 85.3 p. 100 (n = 34) of patients with SS, but only once in controls. Elevated ss DNA were detected in 91.5 p. 100 (n = 47) of patients with SLE and in 18.3 p. 100 of patients with SS but never in controls. Elevated anti-ss DNA were detected in 93.3 p. 100 and 97.1 p. 100 respectively of patients with SLE and SS and in 3.3 p. 100 of controls. There was no correlation between anti-CL and thrombosis, circulating lupus anti coagulant or VDRL. The most striking association, however, was between anti-CL and anti ss-DNA antibodies in SLE. There was no correlation between anti-CL and anti ds-DNA antibodies in SLE patients. Anti CL antibodies were correlated both to ss-DNA and anti ds-DNA in SS patients. Absorption of positive anti-CL antibodies sera were done on DNA (ss-DNA and ds-DNA) affinity column chromatography: anti-CL antibodies were absorbed only by ss DNA in SLE and by both ss DNA and ds DNA in SS.

Adolescent↗