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Biomedical subjects

Y Paul

Publications and source records attributed to Y Paul.

At least 19 recordsLinked to original sources
PubMed1998

Translocation of acylated pardaxin into cells.

Acylated pardaxin is translocated through the cytoplasmic membrane and is accumulated in the nucleoli of NG108-15 and chromaffin cells. The uptake is time- and dose-dependent and temperature-sensitive. However, the binding of acylated 125I-pardaxin cannot be reduced by competition with pardaxin acylated with Rudinger's reagent. In this respect, acylated pardaxin resembles the Tat protein 37-71 fragment. Metabolic inhibitors do not significantly reduce the uptake of acylated 125I-pardaxin. Acylated pardaxin might be useful as a vector to translocate other molecules.

Acylation↗
PubMed1998

Isolation, characterization and synthesis of a novel paradaxin isoform.

We report the isolation of a novel pardaxin isoform from the toxic secretion of the Red Sea Moses sole (Pardachirus marmoratus). Mass spectrometrical analysis of the newly purified peptide revealed a different primary structure compared to the previously known pardaxin isoforms. Sequence analysis disclosed an aspartic acid residue instead of glycine at position 31 of the new isoform. According to the novel sequence, a synthetic Asp-31-peptide was compared with the native compound as well as with synthetic Gly-31-pardaxin. The isolated Asp-31-pardaxin isoform and its synthetic analog exhibited identical elution properties during reverse-phase HPLC, as well as similar dose-dependent lytic effects on human erythrocytes at a concentration of 10(-6) to 10(-5)M. The hemolytic activity of Asp-31-pardaxins was lower than that of Gly-31-pardaxin and no synergistic effect between these peptides was found. The additional negative charge introduced by Asp-31 is likely to affect the selectivity of pardaxin pores towards a variety of ions.

Amino Acid Sequence↗
PubMed1998

Painful pricks.

Explore the source record for details and available documents.

Anesthetics, Local↗
PubMed1994

Immunization practices amongst pediatricians: a postal survey.

A postal survey regarding immunization practices amongst pediatricians was conducted. Out of 250 contacted, 108 responded (43.2%). The responders consisted of senior pediatricians, out of which 31 were serving or were retired Professors of Pediatrics from various Medical Colleges (27.7%). The survey showed that 20.4% give 3 doses of OPV during the first year, 18.5% give 4 doses and 61.1% give 5 doses. Only 11.1% give one "booster" dose of OPV, 72.2% give 2, 13% give 3 and 3.7% give 4 or more "booster" doses. Only 11.1% give "booster" doses upto the age of 2 years, 76.9% upto 5 year, while 12% give "booster" doses beyond the age of 5 years--some upto 14 years of age. Thirty six per cent advice 4 weeks and 36.1% advice 4-6 weeks interval between 2 OPV doses. Nearly one fifth (22.7%) give BCG "booster" doses upto 5 years of age and 6.5 give "booster" to adolescents. Thirteen per cent give Measles/MMR vaccines booster dose beyond the age of 2 years upto 16 years. This study shows that pediatricians follow different schedules and regimes for almost all the vaccines. Often similar schedules are not practised by pediatricians working in the same institutions.

BCG Vaccine↗
PubMed1991

Comparative study of ultrasonography and oral cholecystography in evaluation of gallbladder and biliary tract diseases.

50 cases, aged between 14-60 years, clinically suspected of gall-bladder and biliary tract diseases were evaluated by ultrasonography and oral cholecystography. Ultrasound with a preliminary radiograph of gallbladder region, proved to be more sensitive and reliable procedure than oral cholecystography. Besides providing ancillary information regarding adjacent anatomic structures, it also guided the surgeon to decide preoperatively about the mode of surgery to be employed. Further, from the present study it can be fairly concluded that ultrasound should be used as the primary screening technique for evaluating gallbladder and biliary tract diseases, after plain skiagram of the gallbladder region, since it is non-invasive, more sensitive than OCG and is devoid of use of contrast media and its toxicity.

Adolescent↗