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Biomedical subjects

Y Ono

Publications and source records attributed to Y Ono.

At least 1,117 records · Page 62Linked to original sources
PubMed1980

[Computed tomography in diagnosis and management of acute head injury--correlation between clinical symptoms and CT findings (author's transl)].

A series of 202 patients with acute head injuries was investigated in correlation with clinical signs and computed tomographical findings. Clinical signs were classified into four types according to ARAKI's grading. Ninety three cases of type I, 61 cases of type II, 41 cases of type III and 7 cases of type IV were included in this series. The youngest patient was 40 days old and the oldest was 83 years old and average age was 31.3 years old. Initial C.T. was carried out in 70.80% of this series within 2 days after injury. Conclusions were obtained as follows: 1) Intracranial hemorrhages were recognized in 5.4% of type I, 18.0% of type II, 68.3% of type III and 100% of type IV on C.T. 2) All of intracranial hemorrhage in type I and type II were small and limited ones and showed no mass effect on C.T. 3) In all of severe cases with deep coma, their C.T. demonstrated poor visualization of so-called pentagone, ambient cistern and quadrigeminal cistern. These findings especially that of quadrigeminal cistern image were considered to be signs of poor prognosis. 4) Incidence of visualization of Sylvian fissure decreased in order of type I, type II, type III and type IV on C.T. Poor visualization of Sylvian fissure may reflect of small lesion in or out of cortex near Sylvian fissure such as small intracerebral hemorrhage, localized brain edema, small epidural hematoma etc. 5) Incidence of visualization of sulci decreased in order of type I, type II, type III, and type IV. Poor visualization of sulci may reflect existence of small lesion in or out of cortex in vertex area. 6) False negative of false positive finding on C.T. can result from slice level or time of C.T. and/or age of patient. Repeated C.T. may be recommended when the patient has conflicting neurological signs for these C.T. findings.

Adolescent↗
PubMed1979

Lactose intolerance associated with cataracts.

A 50-day-old boy with severe lactose intolerance is described. In addition to vomiting, failure to thrive, dehydration, metabolic acidosis and amino aciduria, bilateral cataracts were also found. At three months of age, a computerized axial tomography scan and an electroencephalogram were abnormal, and myoclonic spasms began at the age of seven months.

Cataract↗
PubMed1979

Crystalloid inclusions reminiscent of Hirano bodies in autolyzed peripheral nerve of normal wistar rats.

In a study of experimental autolysis of peripheral nerves of normal Wistar rats, crystalloid inclusions similar to Hirano bodies were observed. They occurred in the nuclei and cytoplasms of Schwann cells and in myelinated axons. They first developed after a 12-h autolysis and increased in number and size with time. Their fine structure, localization, and morphogenesis are discussed in relation to the autolysis of the cellular organelles.

Animals↗
PubMed1979

Variation of two forms of DNA polymerase-alpha during a HeLa cell cycle.

HeLa cells contain two forms of DNA polymerase-alpha (P-I and P-II) with varied affinity to DNA, separable on a DNA-cellulose column. The activity of each form was followed during a cell cycle of synchronized culture of the HeLa cells. P-I was recovered from the nuclear extract and P-II from the cytoplasmic fraction. The P-I activity remained at a low level during M to G1 phase until a marked increase between late G1 and S phases, while P-II activity increased gradually throughout the period. Both activities attained their highest level at mid-S phase and then the P-I activity declined more rapidly than the P-II. Addition of hydroxyurea at mid-S phase inhibited the decrease of both enzyme activities. The enzyme activity of nuclear extract from S phase cells was not inhibited by mixing with extract from M phase cells. When the cytoplasmic fraction from M phase cells was chromatographed on a DNA-cellulose column, single activity peak was observed at the position of P-II. These results suggest that the decrease in P-I activity is neither due to the presence of an inhibitor nor to mere release of the enzyme from chromosomes.

Cell Cycle↗