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Y Ono

Publications and source records attributed to Y Ono.

At least 1,063 records · Page 59Linked to original sources
PubMed1982

[Myocardial imaging in patients with Kawasaki disease: exercise stress imaging and serial studies].

Thallium-201 myocardial imaging was performed in 80 children with coronary arterial lesions due to Kawasaki disease in order to assess the value of serial and exercise myocardial imagings. In eight of these children, abnormalities of the image were noted. Twenty children had serial thallium studies with an interval of three to 18 months, and five of these showed changes in the image including appearance of a new perfusion defect in one patient and improvement of perfusion defects in four. These changes of the myocardial image were correlated well with coronary angiographic findings obtained within a few days of the isotope studies. It was noted that the changes of the myocardial image were more frequently observed at relatively recent period recovered from Kawasaki disease. Exercise myocardial imaging using a bicycle ergometer was performed in eight children with coronary arterial lesions. In three an evidence of improvement of the myocardial perfusion was noted immediately after exercise as well as on the delayed image. In one patient, a decrease of the perfusion in the apex and inferior wall was noted immediately after exercise. On the observed image, image of the apex improved but that of the inferior wall remained hypoperfused. Thus thallium-201 myocardial imaging was considered to permit the best noninvasive documentation of ongoing myocardial perfusion abnormalities in patients with Kawasaki disease. Exercise myocardial imaging was found to be useful in differentiating the viable from nonviable myocardium. It was to be emphasized that quantitative evaluation by computer-assisted analysis was particularly valuable in detecting small areas and in a comparison of the myocardial images.

Adolescent↗
PubMed1982

[Myocardial imaging in patients with transposition of the great arteries: comparison between Mustard and Rastelli operations].

Thallium-201 myocardial imaging was performed in 21 patients with transposition of the great arteries (TGA). Thirteen patients were studied before operation, eight patients after Mustard operation and five patients after Rastelli operation. Five patients were studied sequentially before and after the surgery. Each image was compared with hemodynamic and angiographic findings in order to assess the usefulness of this method. In the 13 patients with preoperative TGA, it was possible to differentiate TGA with the intact ventricular septum from TGA with associated anomalies such as patent ductus arteriosus or ventricular septal defect, and also TGA with pulmonary hypertension or pulmonary stenosis from TGA without them by evaluating the degree of thallium uptake in the free wall of the pulmonary ventricle (anatomical left ventricle). The degree of thallium uptake was well correlated with systolic pressure of the pulmonary ventricle (r = 0.98). In the 13 patients with postoperative TGA, it was less correlated with the pulmonary ventricular systolic pressure (r = 0.83). Four cases sequentially studied showed a marked decrease in thallium uptake in the pulmonary ventricle 10 to 16 months after Rastelli operation. But the corrected thallium uptake (thallium activity/ventricular systolic pressure) was more increased compared with the uptake of the systemic ventricle after the surgery. This was probably related to a decrease of the pressure load to the pulmonary ventricle following the surgery and to the fact that there should be some delay of a decrease of the ventricular mass. An increased lung uptake of thallium was noted in the cases of tricuspid regurgitation after Mustard operation, but the degree of regurgitation was not clearly correlated with the increase of thallium uptake in the lung. In five cases after Rastelli operation, one patient showed a high degree of thallium uptake of the pulmonary ventricle (anatomical right ventricle), and the conduit valve calcification and severe pulmonary stenosis were confirmed by cardiac catheterization and angiography. Thus myocardial imaging provides a reliable mean for the qualitative and quantitative assessment of TGA before and after operation.

Child, Preschool↗
PubMed1981

A comparative study on the toxicity of n-hexane and its isomers on the peripheral nerve.

Commercial hexane which caused polyneuropathy in many workers contained 10-40% of 2-methylpentane, 3-methylpentane and methylcyclopentane in addition to n-hexane. The hexacarbon compounds methyl n-butyl ketone, 2,5-hexanedione and etc. were shown to be neurotoxic like n-hexane. Therefore, 2-methylpentane, 3-methylpentane and methylcyclopentane which are also hexacarbon compounds were suspected to be neurotoxic, but their neurotoxicity had not been sufficiently investigated. The present experiment was performed to clarify their neurotoxicity by measuring the nerve conduction velocity in the rat's tail. Thirty rats were divided into five groups of 5-7 rats. n-Hexane, 2-methylpentane, 3-methylpentane and methylcyclopentane were diluted with olive oil and orally administered daily for eight weeks. The body weight, motor nerve conduction velocity, motor distal latency and mixed nerve conduction velocity were measured before administration, after two, four, six and eight weeks' administration. The n-hexane group showed a distinct impairment of the functional states of the peripheral nerve. Methylcyclopentane, 2-methylpentane and 3-methylpentane group had some significant differences in comparison with the control in the experiment, although these differences were not so distinct as those in n-hexane group. The results revealed that the neurotoxicity of the three chemicals was not so severe as that of n-hexane and were in the order of n-hexane greater than methylcyclopentane greater than or equal to 2-methylpentane divided by 3-methylpentane.

Animals↗
PubMed1981

Dismembered pyelolithotomy: new procedure for removal of renal calculi.

A new operative technique for the removal of renal calculi, dismembered pyelolithotomy, is described. This operation was performed on 6 patients with staghorn renal calculi or multiple renal calculi with satisfactory results. This approach is effective in removing renal calculi without renal ischemic damage.

Humans↗
PubMed1981

Principles of surgical treatment for carcinoma of the esophagus: analysis of lymph node involvement.

Extensive lymph node dissections in the posterior mediastinum and abdomen were performed during resections of esophageal carcinomas. Analysis of lymph nodes demonstrated a widespread distribution of positive lymph nodes regardless of the location of the tumor. The distribution of positive lymph nodes was noticed in the area between the superior mediastinum and the celiac region. The studies were also made on the distribution of positive lymph nodes in the superior gastric region, particularly in the region of the lesser curvature of the stomach. The following principles should be followed when carcinoma of the esophagus is surgically treated. 1) Lymph node dissection of the whole length of the posterior mediastinum, superior gastric region, and celiac region must be performed. 2) Total thoracic and abdominal esophagectomy with resection of the proximal lesser curvature and cardia, including the first to fourth branches, and preferably the fifth branch of the left gastric artery, is mandatory in order to remove possible lymphatic and intramural spread of tumors. 3) Satisfactory esophageal replacement in one stage must follow. Of the Toranomon Hospital, 210 underwent resections and reconstructions, for a resectability rate of 59.3%. The operative mortality rate was 1.4% and the overall five-year survival rate was 34.6%.

Adult↗
PubMed1981

An experimental study on the combined effects of n-hexane and toluene on the peripheral nerve of the rat.

An electrophysiological study was undertaken to determine whether toluene affected the neurotoxicity of n-hexane. Separate groups of eight rats were exposed to 1000 ppm n-hexane, 1000 ppm toulene, 1000 ppm n-hexane plus 1000 ppm toluene, of fresh air in an exposure chamber for 12 hours a day for 16 weeks. The body weight, MCV, DL, MNCVs were measured before exposure, after four, eight 12, and 16 weeks exposure; and four weeks after exposure was discontinued. Exposure to 1000 ppm n-hexane considerably impaired the function of the peripheral nerve, but exposure to a mixture of 1000 ppm n-hexane plus 1000 ppm toluene resulted in only slight impairment; 1000 ppm toluene had little effect. These results strongly suggest that toluene decreases the toxic effects of n-hexane on the peripheral nerve.

Animals↗
PubMed1981

[An occupational health survey on dry cleaning workers (author's transl)].

In order ot clarify the working conditions and health of dry cleaning workers, we investigated dry cleaning workshops in C ward of Nagoya City. We had the responses from 52 (91%) workshops and 181 (97%) workers. 26 (50%) of the workshops used petroleum solvents, 23 (46%) perchloroethylene, two (4%) 1, 1, 2-trichloro-1, 2, 2-trifluoroethane (R 113), and one (2%) petroleum solvent plus perchloroethylene. Average amounts of solvents consumed per workshop were 1280 kg/year of petroleum solvents, 1450 kg/year of perchloroethylene, and 275 kg/year of R 113. Average number of workers employed in 19 workshops per workshop was 3.6 persons (median 2.0), and the remaining 33(63%) workshops had no employee. The workers complained of strange smell, irritation of eyes, unsteady feeling of head at high rate during week. They also had the high rate of complaints of shoulder stiffness, fatigability, lumbago, and the percentages of them were higher in the workers using petroleum solvents than those in the workers using perchloroethylene. More detailed surveys were made in 13 workshops out of 52. In these cases, average working hours were 11.1 per day and average years of using solvents were 12.9 in workshops using petroleum solvents, 8.4 in those using perchloroethylene including 3.1 years of petroleum solvents. Relatively high concentrations of solvents were detected under the nose of the workers pulling clothes out of dry cleaning machines, near the clothes just pulled out, and about 30 cm above the clothes at brushing with solvents before putting them into the machines. Perchloroethylene leaked from the dry cleaning machine in a workshop. Amount of the total trichlorinated compounds (TTC) in the urine of the workers directly engaged in dry cleaning with perchloroethylene tended to be larger than those of the indirect workers. TTC in both groups, however, were significantly larger than those in the control and in the workers using petroleum solvents. RBC, Hb, an Ht of the female workers in the petroleum solvents workshops were lower than those in perchloroethylene workshops. Liver function tests showed that the average values in the workers directly engaged in dry cleaning with perchloreothylene were significantly larger than those in the indirect workers. A case of malignant lymphoma, a case of liver dysfunction and a case of diabetes mellitus were found among workers directly engaged in dry cleaning. Workers in the small-sized dry cleaning workshops would not be prevented from exposure to organic solvents without the further improvement of administrative guidance and cooperation of the makers of dry cleaning machines and solvents.

Adult↗
PubMed1981

Quantitative analyses of specific B cells for sheep red blood cell, phosphorylcholine, and hepatitis B surface antigen in human B cell populations by polyclonal transformation with Epstein-Barr virus.

An experimental system was developed to analyse quantitatively specific B cells for various antigens in human B cell populations by polyclonal transformation and immunoglobulin production induced by in vitro infection with Epstein-Barr virus (EBV). EBV-infected cells were cultured in microtest plates for three weeks and specific antibody activities for sheep red blood cell (SRBC) were detected in the culture supernatants by hemolysis and those for phosphorylcholine (PC) and for hepatitis B surface antigen (HBsAg) by passive hemagglutination. It was shown that frequencies of positive cultures with specific antibodies followed one hit-type of Poisson's distribution. Large numbers of cultures showed specific antibody activities for SRBC and for PC with tonsillar lymphocytes obtained from four donors. On the other hand, positive cultured with anti-HBsAg antibodies were practically undetectable with three donors. With fourth donor, however, quite a large fraction of cultures showed specific antibody activities for HBsAg. Frequencies of positive cultures with anti-HBsAg antibodies were further analysed with peripheral blood lymphocytes obtained from five donors with serum anti-HBsAg. Comparable frequencies of cultures were shown to be positive with anti-SRBC antibodies with these donors. The frequencies of cultures with anti-HBsAg antibodies were, however, quite variable among these donors. It was considered that these results directly reflected the sizes of clones with these specificities in human lymphocytes populations obtained from donors with various immunological histories.

Animals↗
PubMed1981

Estimation of B-cells transformed by Epstein-Barr virus in patients with congenital agammaglobulinemia.

In vitro immunoglobulin synthesis was measured in lymphocytes from four patients with congenital agammaglobulinemia (cA gamma) stimulated by two different polyclonal B-cell activators, pokeweed mitogen (PWM) and Epstein-Barr virus (EBV). In PWM-stimulated cultures, patient T-cells treated with mitomycin C (MMC) were able to help the immunoglobulin (Ig) synthesis of normal B-cells. Patient B-cell-enriched fraction not containing surface Ig positive cells did not produce Ig in combination with MMC-treated autologous or allogeneic T-cells. Patient lymphocytes were infected with EBV and the subsequent production of Ig was measured. In lymphocytes from control subjects, exponential growth of the cells having EBV-associated nuclear antigen (EBNA) was shown to be associated with an exponential increase in Ig secretion within 1 week after EBV infection. However, in lymphocytes from three of the four patients, it took 2, 4 and 10 weeks, respectively, until lymphocyte-transformation and subsequent Ig-secretion were observed. Lymphocytes from one patient were not transformed nor did they secrete Ig after EBV infection. These results may imply that a small number of B-cells are present in peripheral blood of most of patients with cA gamma, and that they are able to produce the Ig after transformation by EBV which takes a much longer time than in controls.

Agammaglobulinemia↗