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Biomedical subjects

Y Ono

Publications and source records attributed to Y Ono.

At least 811 records · Page 45Linked to original sources
PubMed1989

Afferent and cardiodynamic drives in the early phase of exercise hyperpnea in humans.

The ventilatory and cardiac responses to voluntary and passive exercise were studied in 20 healthy subjects. These responses to passive leg exercise were also studied in 23 patients with spinal cord transection at the level of T5-T12. In the normal subjects, minute ventilation (VE) increased abruptly from the first breath after the onset of the two types of exercise. In contrast, cardiac output (Q) increased gradually in voluntary exercise, exhibiting significant augmentation from the fifth breath. Q changed insignificantly in passive exercise. In the patients with spinal cord transection, neither VE nor Q changed with passive exercise. These results suggest that ventilatory responses at the onset of mild exercise are related to drives from the moving limbs. We could not detect any evidence to support cardiodynamic hyperpnea at the onset of exercise.

Adolescent↗
PubMed1989

Effects of 2(3)-tert-butyl-4-hydroxyanisole pretreatment on cefpiramide binding to mouse glutathione S-transferases.

Binding of cefpiramide (CPM) and other beta-lactam antimicrobial agents to 2(3)-tert-butyl-4-hydroxyanisole (BHA)-induced liver glutathione (GSH) S-transferases (EC 2.5.1.18) from CD-1 mice was studied. A marked induction of hepatic GSH S-transferase from mice fed BHA was observed. Gel chromatography of liver cytosol from mice fed BHA showed an increased binding of CPM, cefotetan and cefazolin to BHA-induced GSH S-transferases. The extent of their binding to GSH S-transferase seemed to be correlated with the extent of their excretion into the bile. Binding of CPM to the GSH S-transferase fraction was inhibited by both indocyanine green, which is known to bind liver GSH S-transferases intensively, and by cefoperazon, which is mainly excreted into the bile. This study suggests that GSH S-transferases are the main binding proteins of CPM in the liver cytosol fraction and play an important role as carrier proteins of CPM and some antimicrobial agents in mouse liver.

Animals↗
PubMed1989

[An electromyographic study of the inferior heads of the lateral pterygoid muscles during displacements of mandible].

The purpose of this study was to investigate electromyography of the inferior heads of lateral pterygoid muscles in experimental displacement of mandible, and its clinical application for reproduction and diagnosis of mandibular position. In the experiments, the mandibular position was changed in vertical and horizontal directions and muscle activity of the inferior heads was analyzed quantitatively. The results obtained were as follows: 1. Muscle activity of inferior heads was increased with amount of the displacement in anterior direction, and reached to great increase in 1.0 mm and 2.0 mm displacement of mandible. 2. No definite tendency of ipsilateral inferior heads was shown in lateral displacement of mandible. 3. Muscle activity of contralateral inferior heads in lateral displacement was increased with amount of the displacement, and 3 muscles showed great increase in 1.0-2.0 mm displacement of mandible. 4. As vertical increase was less than 2.0 mm, muscle activity of the inferior heads was decreased as to that of intercuspal contact position. 5. Muscle activity of the inferior heads in retruded position showed a little increased, but evidently as to that of intercuspal contact position. 6. Increasing patterns of muscle activities in anterior displacement were different from in contralateral displacement. 7. In anterior mandibular position an ability of presuming a mandible displacement over the limits of 1.0 mm from intercuspal contact position was suggested using muscle activity of inferior head as an index, and in lateral mandibular position that over the limits of 1.5 mm suggested.

Electromyography↗
PubMed1989

[Usefulness of bone imaging in diagnosis of sternocostoclavicular hyperostosis].

Sternocostoclavicular hyperostosis (SCCH) is a rare disease that is characterized by hyperostosis and soft tissue ossification between the clavicles and the anterior part of the upper ribs. There have been few published reports of 99mTc-MDP bone imaging findings in this disease. Thirty-three patients who were suspected to have SCCH were studied with 99mTc-MDP bone imaging. Bone images were abnormal in 31 (94%) of 33 patients. Chest radiographs were available in 30 patients, but negative in 14 (46%) of them. Bone imaging revealed also radionuclide accumulations in other bones such as the vertebrae, femur or sacroiliac joints in ten (14 sites) of 33 cases. Bone scintigraphy was useful in the diagnosis of sternoclavicular hyperostosis.

Adult↗
PubMed1989

[Reconstructive surgery of obstructive disease of the upper urinary tract].

Efficacy of reconstructive surgery for the obstructive disease of the upper urinary tract was evaluated. Reconstructive surgery was performed in 75 units of the urinary drainage system of 72 patients between July, 1977 and December, 1987. 44 patients were male and 28 were female. The patients ranged in age 1 to 71, mean +/- S.D. being 43 +/- 14 years old. Original diseases were postoperative scar, scar due to the calculi, injury, retroperitoneal fibrosis, ureteritis, tuberculosis, amyloidosis and multiple ureteral diverticulum. The surgery consisted of ureterocalicostomy, renal descensus, descent of right renal vein, uretero-ureterostomy, ureteroneocystostomy (to the dome of the bladder), psoas bladder hitch and renal autotransplantation. Renal autotransplantation was chosen instead of ileal substitution to preserve the continuity of the urinary drainage system, when the upper urinary tract was extensively damaged. The obstructive change of the upper urinary tract improved or disappeared in 66 of 75 units. However, it persisted in 9 units, which were treated with ureterocalicostomy (wrong technics; in 4 units), ureteroureterostomy (wrong choice of the procedure; in 4 units) and autotransplantation (cessation of anti tbc drugs; in 1 unit). In 3 of these 9 units, additional reconstructive surgery was necessary. One patient who was treated with autotransplantation, died of massive bleeding from rupture of arterial anastomosis on 14th postoperative day. No other life-threatening complications were observed. Deterioration of the renal function was observed in two severely damaged kidneys which were performed autotransplantation, although the obstructive change of their urinary tract completely disappeared.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

[Magnetic resonance image of pituitary adenoma--comparison of functioning tumor and non-functioning tumor].

Thirty three cases of pituitary adenoma were examined by MRI with 0.15 T system. Eight cases of functioning tumor showed iso-minimally low intensity, and 10 cases of non-functioning tumor did slightly-markedly low intensity on IR image. Functioning tumor cells contain well-developed rough-surfaced endoplasmic reticulum, Golgi complexes and numerous secretary granule, so that bound water more increases and T 1 relaxation time less prolongs in functioning tumor than in non-functioning tumor. Two cases of functioning tumor disclosed slightly low intensity on IR image because of its poor stroma. It is necessary to know the exact bleeding time so as to measure the signal intensity in pituitary apoplexy case. Microadenoma appeared spotty hypointensity and upward convexity of superior surface of the gland on IR image.

Adenoma↗
PubMed1989

[Study on the plasma plasminogen activators in patients with malignant gynecologic tumors].

Increased plasminogen activator (PA) secretion has been observed in malignant cells and tissue and PA is thought to be involved in the processes of tumorigenesis, cancer invasion and metastasis. Recently two types of plasminogen activator--tissue type PA(tPA) and urokinase type PA(uPA)--have been detected in human plasma. In this study, to investigate the relationship between circulating PA and the malignant state, we measured the plasma PA concentrations (PA activity, tPA and uPA antigen) in 69 women with gynecologic malignancies (cervical cancer 50, ovarian cancer 19). These concentrations were compared to those in control groups of 33 women with benign gynecologic tumors (uterine tumor 8, ovarian tumor 25). An enzyme-linked immunoassay for tPA and uPA antigens was performed by the modified method described by Takada et al. (1986). PA activity was measured by the sensitive spectrophotometric assay of Verheijen et al. (1982). The blood samples were taken from an arm vein with a minimum of venous occlusion before treatment. There was no correlation between PA activity or uPA antigen levels and the malignant state. However, in the case of uterine tumors, a significantly higher concentration of tPA antigen (10.5 +/- 5.1 ng/ml) was found in patients with cervical cancer, in stage IV, than in those in the benign group (5.2 +/- 2.0 ng/ml). Moreover the tPA antigen concentration in cervical cancer, stage IV, was higher than in stages 0-III.(ABSTRACT TRUNCATED AT 250 WORDS)

Antigens↗
PubMed1989

[Two cases of temporomandibular arthrosis of young children].

Two cases of temporomandibular arthrosis were reported. Case 1 was a 6 years 4 months old female with pain in her left mandibular region in moving her jaw. Opening of the mouth by herself was slightly limited. Clicking noise was seen and felt from both of her temporomandibular joints. She was in the dental developmental stage IIA by Hellman, and had deep overbite (5mm). Roentogenographic examination revealed a bony defect on her left condylar head. Treatment was performed with an activator. Pain was not felt and the mandibular opening recovered after 2 weeks of treatment. Roetogenographs showed no bony defect on her left condylar head after 5 months of treatment. Case 2 was a 3 years 2 months old male with clicking noise from both of his temporomandibular joints. There was no pain and no limitation of his mouth opening. He was in the dental developmental stage IIA by Hellman, and had large overjet (8mm). He has thumb sucking habit since the age of one year. He is now under regular observation.

Activator Appliances↗
PubMed1989

[Effect of the portal vein injection of cisplatin and lipiodol on rat liver].

The purpose of this study was to elucidate the efficacy and safety of cisplatin powder, suspended in lipiodol, as a means for the treatment of liver cancer by injection into the portal vein. The effects of lipiodol (0.1 ml. 0.2 ml. 0.3 ml. 0.4 ml) alone, as well as that of cisplatin powder (1.0 mg) suspended in lipiodol or saline (0.1 ml), on the liver, was investigated by administration of them into the portal vein in 100 normal Wistar rats. The results revealed that the hepatic cells were moderately affected by a small amount of lipiodol alone, but a large amount of lipiodol caused multiple anemic infarctions in the peripheral area of the liver. And, also the injection of cisplatin powder suspended in lipiodol, compared to that suspended in saline, resulted in higher concentration of platinum in the liver. Histologically severe degenerative changes were also perceived in the liver, but these changes were reversible. These results suggest that cisplatin powder suspended in lipiodol is to be used for the treatment of liver cancer.

Animals↗
PubMed1989

[Ultrasonic evaluation of two cases of islet cell tumor of the pancreas].

Small pancreatic tumor is difficult to be diagnosed. Two cases of pancreatic islet cell tumors were examined by ultrasonography. One case was islet cell carcinoma, the other insulinoma. In both cases, ultrasonography was useful in detecting the tumor, judging the location of tumor during surgical operation and deciding the surgical procedure.

Adenoma, Islet Cell↗
PubMed1989

[A long surviving hepatocellular carcinoma case (2 years 1 month) with tumor thrombus in the portal trunk treated by embolization].

A 55-year-old male patient suffered from hepatocellular carcinoma (HCC) with tumor thrombus in the portal trunk and cavernous transformation in the liver hilus. He was treated 4 times effectively by transcatheter arterial embolization (TAE). Tumor thrombus in the portal trunk which was demonstrated by portography before TAE disappeared following initial TAE. He is still alive 2 years and 1 month after initial TAE. We reported a long surviving case with advanced HCC treated by TAE and TAE for advanced HCC was discussed.

Carcinoma, Hepatocellular↗
PubMed1989

[Evaluation of the collo-thoraco-abdominal dissection for the intrathoracic esophageal carcinoma].

Five hundred and forty three cases of intrathoracic esophageal carcinoma were reviewed. Of these, one hundred and sixty one cases had collo-thoraco-abdominal (CTA) dissection and three hundred and eighty two cases had thoraco-abdominal (TA) dissection. Postoperative pulmonary complications occurred in 35.5% of the patients who had CTA dissection and in 18.0% of those who had TA dissection. Incidences of postoperative hoarseness of voice and anastomotic leakage were almost similar in the two groups. However, the mortality rates within 30 postoperative days was 4.3% for the CTA groups compared to 1.8% for the TA group. The average number of lymph nodes resected per case was much higher in the CTA group than than the TA group. This implied that the dissection was more extensively performed in the CTA group involving not only bilateral cervical regions but also the upper mediastinum continuing into the neck. Better 1, 2 and 3 years survival rates were observed in the CTA group than the TA group, but for the 4, 5 years survival rates there was no statistical difference noted. For stage-0 and stage-4 carcinoma of the upper third esophagus, marked improvement in the survival rates were obtained in the CTA dissection cases. In conclusion, collo-thoraco-abdominal dissection can be justified for the surgical treatment of intrathoracic esophageal carcinoma despite its postoperative mortality rate of 4.3%.

Abdomen↗
PubMed1989

Diabetes insipidus caused by lymphocytic infundibuloneurohypophysitis.

Pathologic examination at autopsy of a 74-year-old man with central diabetes insipidus revealed that he had a chronic lymphocytic inflammation limited to the infundibulum, stalk, and posterior lobe of the pituitary gland. No meningitis, sarcoidosis, or granulomas were detected, though there was evidence of chronic pancreatitis. In addition, neuronal loss with gliosis was observed bilaterally in the supraoptic and paraventricular nuclei. The unusual localized inflammatory brain lesion was considered to be responsible for the diabetes insipidus.

Aged↗
PubMed1989

[Gallium-67 imaging in patients with myocarditis in childhood and youth].

Gallium-67 (Ga-67) myocardial imaging was performed in 19 patients (1 month to 21 years of age) with proven or suspected myocarditis. The anterior images, 48 hrs after the intravenous administration of 0.5-2.0 mCi Ga-67 citrate, were analysed using a computer. Regions of interest were set on the heart, lungs and background, excluding the sternum and vertebrae. The uptake of Ga-67 was evaluated quantitatively by the ratio of the average count of the heart to the average count of the lung (H/L). When the H/L value was higher than 130% the cardiac uptake of Ga-67 was designated positive. Histological examination was performed in 11 patients who underwent right endomyocardial biopsy. The patients were categorized according to their clinical findings. Group 1 consisted of 11 patients with clinical symptoms of dilated cardiomyopathy, six of whom had arrhythmias or elevated serum CPK-MB levels (group Ia) in the acute stage of the disease, and the remaining five had neither (group Ib). Group 2 consisted of eight patients with dysrhythmias but without heart failure. Four had elevated serum CPK-MB levels (group IIa), but the remaining four did not (group IIb). All patients in the group Ia had positive Ga-67 uptakes, and three patients in the group Ib had negative uptakes. The H/L values were significantly higher in the group Ia than in the group Ib (p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1989

[Isolation right ventricular hypoplasia: report of two cases].

Two cases of the hypoplastic right ventricle are reported. Patient 1: A five-year-old boy underwent cardiac catheterization 13 days after birth which revealed that the end-diastolic volume in the right ventricle was 2 ml. It was 20 ml at the age of two years and 40 ml at five years. Thus, the right ventricular hypoplasia lessened with increasing age. Neither pulmonary nor tricuspid valvular malformation was present. Patient 2: A four-month-old boy received two-dimensional echocardiographic examination at the age of two days which revealed: 1) a small right ventricle in the apical four-chamber view, 2) a half-moon-shaped right ventricle in the subxyphoid short-axis view at the level of the great arteries, and 3) normal positioning of the septal leaflet of the tricuspid valve. Pulsed Doppler echocardiography revealed normal blood flow patterns, immediately above the pulmonary valve and below the tricuspid valve. Cardiac catheterization at the age of three months indicated isolated right ventricular hypoplasia, a diverticulum of the right ventricle, and dilated cardiomyopathy. The patient died of congestive heart failure at the age of four months. Autopsy confirmed the above diagnoses.

Child, Preschool↗