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Biomedical subjects

Y Oku

Publications and source records attributed to Y Oku.

At least 163 records · Page 9Linked to original sources
PubMed1985

Benign chondroblastoma of the occipital bone.

We report the case of a 14-year-old boy with benign chondroblastoma in the occipital bone associated with a cerebellar hemorrhage. The clinical features, radiologic and histologic appearances, and histogenesis in this case are described. Other reports of benign chondroblastomas of the cranial bones are also discussed.

Adolescent↗
PubMed1985

Prolonged expulsion of adult Trichinella spiralis and eosinophil infiltration in mast cell-deficient W/Wv mice.

Eosinophil infiltrations were observed in the intestine and the muscle of both Trichinella spiralis-infected (WBxC57BL/6)F1-W/Wv mice and their littermates, WBB6F1-+/+, +/W, +/Wv, almost to the same extent. W/Wv mice did not show infiltration of subepithelial mast cells and globule leucocytes in response to T. spiralis infection. Increased numbers of these cells were observed in their littermates. Worms in W/Wv mice were retained for longer periods than those in littermates. Also, no difference was noted in the production of specific serum antibodies between W/Wv mice and their littermates, as determined by passive cutaneous anaphylaxis (PCA) for specific IgE and by indirect haemagglutination (IHA). These results suggest a possible participation of SMC, GL and eosinophils in the expulsion of adult T. spiralis.

Animals↗
PubMed1985

Synthesis and deposition of spore coat proteins during sporulation of Bacillus megaterium.

Rabbit (anti-spore coat protein) IgG was prepared by immunization with coat proteins extracted with sodium dodecyl sulfate and dithiothreitol from isolated spore coats of Bacillus megaterium ATCC 12872. Coat proteins were detected from 3 hr after the end of exponential growth (t3) in the mother cell cytoplasmic fraction by sandwich enzyme immunoassay using this antibody. The proteins in the forespore coat protein fraction increased from t3 and reached a plateau at t10. Immunoblot analysis for the coat proteins in sporulating cells revealed the sequential synthesis of various proteins in the mother cell cytoplasmic fraction and simultaneous deposition of the same proteins as in the forespore coat fraction. These results suggest that turnover of precursor proteins of the spore coat is very rapid if precursor proteins are produced and they are proteolytically processed to produce mature proteins. Specific antibody to the 48,000-dalton protein, which is a major protein, did not cross-react with any other major (36,000, 22,000, 19,500, and 17,500-dalton) proteins. Specific antibody to the 22,000-dalton protein did not cross-react with the 48,000, 36,000, 19,500, 17,500, and 16,000-dalton proteins, but did cross-react with the 44,000, 25,000, and 12,000-dalton proteins.

Animals↗
PubMed1985

[von Hippel-Lindau disease--hemangioblastoma associated with pheochromocytoma].

The association of a pheochromocytoma with von Hippel-Lindau disease is uncommon. We had a family with eight patients affected by von Hippel-Lindau disease, of whom five had hemangioblastoma of the central nervous system and seven had pheochromocytoma. As other lesions, retinal angiomatosis, spinal A-V malformation and spinal hemangioma were included in this family. In this paper five hemangioblastomas, four of whom had the association of hemangioblastoma and pheochromocytoma, are presented and clinical features of hemangioblastoma associated with pheochromocytoma are discussed, comparing to the 16 reported cases that had the association of hemangioblastoma and pheochromocytoma. The mean age of our own five cases at the onset of clinical symptoms was 32.2 years (ranging from 24 to 41 years) and that of reported 16 cases was 33.9 years (ranging from 18 to 55 years). These ages are slightly younger than that of sporadic hemangioblastoma. On the other hand, the mean age at the onset of pheochromocytoma was 28.3 years in our cases and 31.0 years in reported cases. This may suggest that hemangioblastoma when it is associated with pheochromocytoma presents its symptoms several years after the signs and symptoms of pheochromocytoma are manifested. In our cases a male to female ratio was 4:1 and in reported ones it was 9:7, showing that hemangioblastoma associated with pheochromocytoma as well as sporadic hemangioblastoma is likely to occur more in male.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenal Gland Neoplasms↗
PubMed1984

Contralateral pterional approach for carotid-ophthalmic aneurysm: usefulness of high resolution metrizamide or blood computed tomographic cisternography.

Four carotid-ophthalmic aneurysms were treated through a contralateral pterional approach. Three of these aneurysms were clipped successfully. Because awareness of the size and shape of the optic chiasm is crucial for the success of this approach, we used metrizamide or blood cisternography with a high resolution computed tomographic scanner. With this technique, the shape of the optic chiasm was delineated before operation to make certain that the prechiasmatic space was large enough for the aneurysm to be approached.

Adult↗
PubMed1984

Trial of a new operative method for recurrent chronic subdural hematoma.

A new operative method for treating recurrent chronic subdural hematoma is presented. This method consists of complete obliteration of the subdural hematoma cavity and conversion of the hematoma cavity into epidural space. The procedure was carried out in three patients with recurrent chronic subdural hematoma, all of whom made a complete recovery.

Aged↗
PubMed1984

Expulsion of Trichinella spiralis from the intestine of W/Wv mice reconstituted with haematopoietic and lymphopoietic cells and origin of mucosal mast cells.

The involvement of haematopoietic and lymphopoietic cells in the expulsion of Trichinella spiralis from the intestine of mice, and the origin of the subepithelial mast cells (SMCs) and the globule leucocytes (GLs) were determined using SMC- and GL-deficient WBB6F1-W/Wv and WCB6F1-S1/S1d mice. On day 12 after infection with T. spiralis, SMCs and GLs appeared in W/Wv mice injected with spleen and bone marrow cells from normal +/+ mice, but not in W/Wv mice injected with thymus, mesenteric lymph node and Peyer's patch cells from +/+ mice or in S1/S1d mice injected with spleen cells from normal mice. On day 22 after infection, GLs and SMCs with giant granules were found in W/Wv mice injected with spleen cells of C57BL/6J-bgJ/bgJ mice in which GLs and SMCs contained giant granules. These results suggested that the precursor cells of SMCs and GLs were located in the haematopoietic tissues. In W/Wv mice reconstituted with SMCs and GLs, expulsion of T. spiralis from the intestine was as rapid as that of the normal mice, but in W/Wv mice injected with lymphopoietic cells and S1/S1d mice which had been injected with normal spleen cell, expulsion of T. spiralis was less rapid. The result suggested that haematopoietic cells containing SMC- and GL-precursor cells might be involved in the expulsion of T. spiralis from the intestine of mice.

Animals↗