Biomedical subjects

Y Nishimura

Publications and source records attributed to Y Nishimura.

1,354 records · Page 76Linked to original sources

PubMedDate not supplied

Outcome of radical multiple synovectomy as a novel surgical treatment for refractory rheumatoid arthritis: implication of HLA-DRB1*0405 in post-operative results.

OBJECTIVE: The authors developed a technique for radical multiple synovectomy (RaMS), a novel surgical treatment for refractory rheumatoid arthritis (RA) intended to control RA activity as much as possible. The purpose of this article is to describe the technique and its short-term results. METHODS: Eighteen RA patients were followed up for at least 3 years after RaMS. Post-operative results were determined and the significance of the HLA-DRB1 alleles was studied. RESULTS: Six patients met the ARA criteria for clinical remission persistently and were classified as "remission" cases. Thirteen patients in whom the limited Lansbury index remained improved were rated as "improvement". The cumulative success rates for "remission" and "improvement" were 33.3% and 57.8%, respectively, at the time point of the latest observation. Remission was not achieved in any of the DRB1*0405-positive patients. Nine out of 10 DRB1*0405-negative patients showed persistent improvement. CONCLUSION: RaMs provided good results in one-third of patients with refractory RA at a minimum of 3 years. HLA-DRB1*0405 may be a good marker to follow the effects of RaMS in RA patients.

Adult↗

PubMedDate not supplied

A novel wound dressing with an antibiotic delivery system stimulated by microbial infection.

The aim of this study was to develop a new wound dressing with controlled release of antibiotics only in the presence of infection. In the first experiment using an infected dorsal pouch of rats, exudate containing proteinases from pouches contaminated with Staphylococcus aureus or Pseudomonas aeruginosa showed significantly higher hydrolytic activity toward Boc-Val-Pro-Arg-MCA than that from noninfected wounds. The authors then developed a new type of wound dressing (AGX), a drug delivery system in which gentamicin is bound to polyvinylalcohol hydrogel through an enzymatically degradable peptide linker containing a -(D)-Phe-Pro-Arg-sequence. To investigate in vitro effectiveness, AGX was incubated with exudate from S. aureus infected or P. aeruginosa infected wounds. Gentamicin was selectively released from AGX in the presence of the exudate from S. aureus infected or P. aeruginosa infected wounds, but was not released in the presence of exudate from noninfected wounds. Next, AGX or the polyvinylalcohol hydrogel that served as control was incubated with S. aureus in the presence of human plasma. After 24 hours, S. aureus concentration was markedly lower in the case with AGX than in that with polyvinylalcohol hydrogel. These results indicate that proteinases from wounds infected with S. aureus or P. aeruginosa cleaved the linker and gentamicin was released.

Animals↗

PubMedDate not supplied

Results of pancreatectomy with radiation therapy for pancreatic cancer.

BACKGROUND/AIMS: Surgical resection provides the only chance for long-term survival for adenocarcinoma of the pancreas. However, a major problem of surgery appears to be post-resection recurrence. The purpose of the current study was to evaluate the efficacy of intraoperative radiotherapy (IORT) and/or external beam radiotherapy (EBRT) in combination with resective surgery. METHODOLOGY: 86 patients received radiotherapy combined with resection surgery and 64 patients received surgery alone. Of 86 patients, 37 received postoperative EBRT, 14 received IORT, and 31 received both. The primary outcome variable analyzed was survival. RESULTS: The survival curve in patients who received radiotherapy combined with resective surgery was significantly better than that in patients who only received surgery (MST: 12.8 vs. 7.9 months). The number of patients in both groups was equally populated on the basis of potentially prognostic factors such as gender and age of patients, type of resection, vascular resection, location of the tumor, and pTNM classification. Among the subgroups of the patients, adjuvant radiotherapy showed significant survival benefit in the patient group with pT3 tumor, pN positive and R0 surgery. CONCLUSIONS: Adjuvant radiotherapy including TORT with resection surgery for adenocarcinoma of the pancreas is accomplished with acceptable risk and provides significant survival benefit.

Adenocarcinoma↗

PubMedDate not supplied

HLA-DRB1 alleles and beta 2 glycoprotein I-dependent anticardiolipin antibodies in Japanese patients with systemic lupus erythematosus.

OBJECTIVE: To investigate the association of HLA DRB1 alleles with beta 2 glycoprotein I (beta 2 GPI)-dependent anticardiolipin antibodies (aCL) in Japanese patients with systemic lupus erythematosus (SLE). METHODS: One hundred and forty-five Japanese patients with SLE were studied. beta 2 GPI-dependent aCL was measured by enzyme-linked immunosorbent assays. DNA typing of the DRB1 alleles was performed by the polymerase chain reaction sequence specific oligonucleotide probe method. RESULTS: beta 2 GPI-dependent aCL was positive in 29 (20.0%) out of 145 SLE patients. SLE patients with beta 2 GPI-dependent aCL had a significantly higher frequency or one or more of the clinical manifestations assumed to be associated with aCL, compared to those without beta 2 GPI-dependent aCL (p < 0.05). The frequency of DRB1*0901 was lower in SLE patients than in healthy subjects. SLE patients with beta 2 GPI-dependent aCL were significantly associated with DRB1*0901 as compared to those without beta 2 GPI-dependent aCL (41.4% vs 15.5%, p < 0.005, R.R. = 3.8), although the corrected P value was not significant. CONCLUSION: A possible association of DRB1*0901 with Japanese SLE patients with beta 2 GPI-dependent aCL was found. This association indicates an association between the disease and the HLA-DR53 (DRB4)-bearing haplotypes in different ethnic groups.

Alleles↗