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Biomedical subjects

Y Nishimoto

Publications and source records attributed to Y Nishimoto.

At least 181 records · Page 10Linked to original sources
PubMed1976

[Relative biological efficiency of neutrons (2 MeV) and X-rays for mastocytoma cell division capacity].

The effects of 2 MeV neutrons were compared with those of 200 kV X-rays for the criterion of lethality in mastocytoma cells of ascites type. The cells prepared as suspension were exposed to the radiations in vitro under aerobic condition and transplanted in the abdominal cavity of mice. Their viability was estimated according to the growing speed of the excreted amount of urinary 5-HIAA in the host animal. The RBE varied between a value of 3.1 at the 10 per cent level of cell survival to 1.8 for the mean lethal dose (Do).

Animals↗
PubMed1976

[Characteristics of a mastocytoma cell line adapted to in-vitro culture].

A cell line adapted to in vitro culture was obtained starting from ascites type mastocytoma cells which were maintained by successive transplantation in mice. The cells make colonies in liquid culture medium as well as on agar plate. In comparison under microscope and of behaviour in abdominal cavity of mice, no difference was detected between cells of this cell line and those of original one.

Animals↗
PubMed1976

Prediction of radiosensitivity of individual mice by multidimensional analysis.

Ten physiological indices on each mouse were measured before an exposure to ionizing radiation. The exposure of mice to 700R of X-rays induced 45% mortality within 30 days. A prediction of death or life of each mouse was done by a multidimensional quantification. The highest success rate of prediction was obtained by using all ten indices and it resulted in 74.1%. Accordingly, it was possible to predict death of individual mice exposed to a dose around LD50 (30) with a high rate of success. When one selected five indices out of the ten indices by some criterion, the success rate of prediction decreased to 67.1%.

Animals↗
PubMed1975

Tryptophan metabolism in various nutritive conditions.

In phenylalanine administered rat, tryptophan chiefly metabolized to xanthurenic acid and in nicotinic acid administration to 5-hydroxy indole acetic acid mainly. MAO reaction inhibited by quinoline compound and the inhibition of kynurenine aminotransferase activity through the injection of epinephrine or serotonin were observed. And also the induction of tryptophanpyrrolase in starvation was discussed.

Animals↗
PubMed1975

[Incapacity of 5-hydroxytryptophan to act against the depression of tumor-resisting power of host animal which is induced by whole body x-irradiation].

The effect of L-5-hydroxytryptophan (L-5-HTP) against the depression of tumor-resisting power in host animal, which is induced by a whole body x-irradiation of 500 R, was studied. Host animal and tumor cell used were LAF, hybrid mouse and mastocytoma cell, respectively. The i.p. injected dose of L-5-HTP was 6.25 mg per mouse, which is most effective for protecting mice from radiation-induced hematopoietic death. In the experimental conditions, the agent was not effective to prevent the radiation-induced depression of tumor-resisting power of the animal.

5-Hydroxytryptophan↗