Rats with hypercalcemia induced by injection of vitamin D2 had a decreased thyroid somatostatin content, whereas the somatostatin content in their pancreas was almost within the normal range. This suggests that somatostatin in different organs acts specifically on each particular organ as a local hormone or hormone-like substance.

Animals↗

PubMed1979

Hypertension and atherogenesis in animal models - a new aspect on the relationship [proceedings].

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Animals↗

PubMed1978

Effect of dietary taurine on blood pressure in spontaneously hypertensive rats.

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Animals↗

PubMed1978

Genetic and environmental modification of spontaneous hypertension.

The further selection of stroke-prone spontaneously rats (SHR) by the grade of hypertension resulted in the separation of substrains with more and less severe hypertension, respectively. Their average tail blood pressures at the age of 100 days were 240 and 200 mmHg. The ratios of cerebral hemorrhage to infarction were markedly decreased from 1/2 in the former into less than 1/30 in the latter. Also a similar attempt separated stroke-resistant SHR into substrains with moderate and mild hypertension; blood pressures at the age of 100 days were 200 and 180 mmHg, respectively. On the other hand, development of severe hypertension was attenuated and the incidence of stroke was significantly reduced in stroke-prone SHR when they were fed on a high-fat-cholesterol diet or a high fish protein diet. The selection of substrains with different grades of hypertension in stroke-prone and stroke-resistant SHR indicates the additional involvement of some hypertension genes, and the alteration of the course and the level of hypertension by nutritional factors substantiates the importance of gene-environment interaction in spontaneous hypertension.

Animals↗

PubMed1978

Glucose tolerance in spontaneously hypertensive rats.

In order to clarify the relationship between essential hypertension and glucose metabolism, and to approach the pathophysiology or the etiology of essential hypertension, we examined glucose tolerance test (GTT) using spontaneously hypertensive rats (SHR) as models. SHR, namely stroke-prone SHR (SHRSP) and stroke-resistant SHR (SHRSR) always had higher serum glucose levels at each GTT phase than normotensive control Wistar-Kyoto rats. They also tended to show higher levels in the young even at 5 weeks of age rather than in the adult. These results indicate that hyperglycemic tendency or lower glucose tolerance may be a characteristic of spontaneous hypertension and may be related to the mechanism of hypertension.

Animals↗

PubMed1978

Glucose metabolism in spontaneously hypertensive rats.

Serum glucose levels in SHR (especially SHR selected for a greater hyperglycemic response) tended to be higher at 'fasting' and were significantly higher after peroral glucose administration than those in normotensive WK. However, plasma immunoreactive insulin was not decreased in SHR as compared with WK. No significant acceleration of gluconeogenesis was observed in SHR.

Animals↗