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Biomedical subjects

Y Nakane

Publications and source records attributed to Y Nakane.

At least 235 records · Page 13Linked to original sources
PubMed1977

[Effects of a proteolytic-enzyme preparation used concomitantly with an antibiotic in osteoarticular infections (author's transl)].

Studies were performed in 8 patients with osteoarticular infections to examine the concentrations of sulbenicillin in the venous blood and exudate following administration and the concentrations of the antibiotic in the exudate when serratiopeptidase was orally administered concomitantly with the antibiotic. The results of the examination indicated that the transfer of sulbenicillin into the exudate tended to increase when 30 mg/day of serratiopeptidase was concomitantly given for 6 days, though further examination was thought necessary by increasing number of subjects and elaborating on the methodology.

Adult↗
PubMed1976

Psychiatric treatment in a delimited population-with particular reference to outpatients. A demographic study.

The present investigation analyses the psychiatric service available to and utilized by a population in a geogrphically delimited area, namely the Randers area with a population of 108.928. During the period 1970-74, the average yearly rate of patients admitted to the three psychiatric institutions covering this area was per 1,000: 7.9 males and 9.1 females. During 1970-71, 1.2 males and 1.8 females per 1,000 were treated as outpatients in a psychiatric clinic affiliated to a psychiatric hospital, and a psychiatric outpatient clinic in a general hospital discharged 4.1 males and 7.7 females per 1,000. It seems probable that despite outpatient treatment the number of admissions increases slightly rather than decreases, and consequently, outpatient treatment cannot replace psychiatric admission.

Adolescent↗
PubMedDate not supplied

Hereditary multiple malformation in Japanese quail: a possible powerful animal model for morphogenetic studies.

Hereditary multiple malformation (HMM), a new mutation of Japanese quail (Coturnix japonica), is controlled by an autosomal recessive gene. The proposed gene symbol for the mutant gene is hmm. The majority of the homozygotes die at the sixth day of incubation, and the remainder die at various stages by 15 days of incubation. The homozygotes surviving to the late embryonic stage have greatly shortened lower and upper beaks that are set apart and show an early embryo-like body shape, with feather buds but no plumules. Furthermore, they show syndactylous polydactyly in both fore and hind limbs. In the abdomen of the homozygote, a part of the ventriculus, liver, and small intestine protrudes out of the umbilicus region. In the skeleton of the late HMM embryos, ossification is generally delayed and morphogenetic abnormalities are observed all over the body. This mutant seems to become a powerful animal model in the research fields for morphogenesis.

Abnormalities, Multiple↗
PubMedDate not supplied

Short beak: a new autosomal recessive semilethal mutation in Japanese quail.

Short break (SBK) is a new semilethal mutation of Japanese quail (Coturnix japonica). The SBK individuals are characterized externally by short breaks, shanks, and digits. The shank is also thicker than the wild type. The shape of the mutant beak does not show a parrotlike appearance, contrasting with that of other poultry chondrodystrophic mutants reported in the literature. Bones in the fore and hind limbs of the SBK mutant are also shorter than the wild types. The humerus and ulna in the wing are significantly thicker than the wild types. Other bones in the wing and leg show approximately the same thickness as the wild types. The majority of the SBK mutants die at the late embryonic stage. Some chicks can hatch with no assistance, but almost all die around 3 days of age. However, a part of the SBK individuals (5.3%, 8/151) reach sexual maturity and can reproduce. Genetic analyses revealed that the SBK mutation is controlled by an autosomal recessive gene. The proposed gene symbol is sbk. The sbk gene is allelic to the previously reported stumpy-limb (sl) gene that expresses a somewhat similar phenotype to the SBK.

Animals↗
PubMedDate not supplied

Clench: a new autosomal recessive mutation in Japanese quail.

The clench (CL) is a new morphological mutation in Japanese quail (Coturnix japonica). The CL mutants rigidly clench their toes in both legs, which gives rise to a human fistlike appearance in the distal ends of the legs. Other parts of the CL body are quite normal. In spite of the severe toe abnormality, the CL mutants are normal in fertility, hatchability, and postnatal viability. Genetic analysis revealed that the CL mutation is an autosomal recessive with 100% penetrance. The proposed gene symbol is cl.

Animals↗
PubMedDate not supplied

Allelism of panda and dotted white plumage genes in Japanese quail.

Panda and dotted white mutant plumage colors of Japanese quail (Coturnix japonica) were found to be controlled by the autosomal alleles. Both mutants showed white plumage with colored spots or patches, but they were easily distinguishable by size and location of the colored areas and the color and markings of the pigmented feathers. At hatching also they were easily distinguishable by the position, size, and colors of the spots or patches. The panda chicks possessed large blackish patches on the head, back, tail, cheek, and wing, whereas the dotted white chicks had small light brown spots on the head and/or back. Some dotted white chicks (12%) did not have any brown spots. In a testcross experiment, panda type and dotted white type progeny segregated in 1:0, 3:1, 1:0, and 1:1 ratios in the F1 and F2 generations and in back-crosses to the panda and dotted white parents, respectively, suggesting allelism and dominance of panda over dotted white. The new gene symbol sdw is proposed for the allele controlling the dotted white plumage.

Alleles↗
PubMedDate not supplied

Teratogenicity of antiepileptic drugs: analysis of possible risk factors.

To determine the primary factors responsible for the increased incidence of malformation in the off-spring of antiepileptic drug (AED)-treated epileptic mothers, special attention was paid to drug combinations in a prospective study of 172 deliveries. Variables used for analysis were eight antiepileptic drugs (AEDs) and total daily dosages (drug score), and seven background factors consisting of maternal age at delivery, gravida, outcome of previous pregnancy, etiology and type of epilepsy, occurrence of seizures in the first trimester of pregnancy, and seizure frequency during pregnancy. The overall rate of malformation was 14.0%. Thirty-one patients were administered a single drug, and the rate of malformation was 6.5%. The remaining 141 patients were treated with multiple AEDs, and the rate of malformation was 15.6%. The drug score of the latter group was significantly higher than the former (p = 0.01). There was no definite dose-dependent increase in the incidence of malformations associated with any individual AEDs. There was no relationship between the type of defect and individual AEDs. Wilcoxon rank-sum test revealed significant association between the drug score, valproate (VPA), and congenital malformation. Carbamazepine (CBZ) also reached an almost significant level. Furthermore, VPA polypharmacy produced the highest incidence of malformation, higher than that produced by any other AED or drug combination. There was no significant association between the presence of malformations and the other putative risk factors. These results suggest that high dose of AEDs reflecting polypharmacy, VPA polypharmacy in particular, are primary factors responsible for the increased incidence of congenital malformation in the offspring of treated epileptic mothers.

Abnormalities, Drug-Induced↗