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Biomedical subjects

Y Mu

Publications and source records attributed to Y Mu.

65 records · Page 4Linked to original sources
PubMed1995

Amino acids and peptides. XXXIX. Synthesis of iNoc-Gln-Val-Val-Ala-Ala-pNA and its action on thiol proteinases.

Based on the results of X-ray analysis of the complex between Suc-Gln-Val-Val-Ala-Ala-pNA, a fairly potent thiol proteinase inhibitor, and papain, iNoc-Gln-Val-Val-Ala-Ala-pNA was designed and prepared and its inhibitory activity against thiol proteinases was examined. iNoc-Gln-Val-Val-Ala-Ala-pNA inhibited cathepsin L fairly specifically, although its potency is not high.

Amino Acid Sequence↗
PubMed1995

[Damage effects of methylmercury on cell membrane].

Damage to cell membrane system caused by methylmercury (Me-Hg) and its mechanism were studied with biochemical and cell biological methods experimentally. Results showed erythrocyte membrane and activities of T-ATPase, Mg(++)-ATPase and Na(+)-K(+)-ATPase of microsome membrane in brain, liver and kidney of the exposed animals decreased more significantly than of controls with a dose-effect pattern. Activities of Mg(++)-ATPase and Na(+)-K(+)-ATPase of erythrocyte membrane correlated positively with those of microsome membrane in brain and kidney. Sulfhydryl content of erythrocyte membrane and brain microsome membrane decreased significantly in the exposed animals (P < 0.01). Sulfhydryl content correlated inversely with the activities of above three kinds of ATPase in kidney, but so did in brain positively. Fluorescent polarization of membranes of erythrocytes and microsome in brain, liver and kidney increased, membrane fluidity decreased, LDH activities increased in plasma and decreased in cells and cell permeability increased in the exposed animals. Activities of respiratory enzymes of mitochondrion in exposed animals were lower than those in controls (P < 0.05). 3H-TdR incorporation was inhibited in spleen, liver and brain in exposed animals. Abilities of DNA synthesis and UDS repair were inhibited with high-dose of Me-Hg, and stimulated with low-dose. SCE frequency in bone marrow cells increased with dose of Me-Hg (P < 0.001). Proportion of splenocyte from G0/G1 to S phases increased and those from S to G2/M phases lowered, and it suggested DNA synthesis had been inhibited.

Animals↗
PubMed1995

[Analysis of luteinizing hormone pulses in men with idiopathic hypogonadotropic hypogonadism].

In order to test the defect of luteinizing hormone (LH) pulses and its relationship with sexual development in patients with idiopathic hypogonadotropic hypogonadism (IHH), fourteen male IHH patients and five healthy adult men were investigated. Blood samples were withdrawn at 10 minute intervals for 24h for analysis of LH pulse. LH pulse frequency ranged from 0-13 pulses/24h. Testosterone (T) level was 1.3-8.7 nmol/L in the 14 IHH patients and higher in the 5 healthy controls (all P < 0.01). Two of the patients with IHH had no detectable LH pulsations (apulsatile pattern), no history of puberty and a small testicular volume of less than 1ml. Most of the IHH patients (n = 9) had less pulse frequency (4-13 pulses/24h) and lower mean amplitude (1.3-2.2IU/L) than the healthy controls (14-20 pulses/24h and 3.81-2.46IU/L, P < 0.01). A patient with IHH had 10 pulses/24h and more or less the same mean amplitude (4.2 +/- 1IU/L) as the healthy controls; his T level was the lowest among the 14 patients due probably to biological inactivity of LH. Two IHH patients had detectable LH pulsations with normal mean amplitude (P > 0.05) present predominantly during the night, this pattern of LH pulse resembles that of peripuberty boy. Our results indicate that (1) LH pulse pattern varies widely among IHH patients and it is related to the sex characteristics; (2) frequency of LH pulses is essential for sexual development. but adequate amplitude is more important in this respect.

Adolescent↗
PubMed1992

One-atom lasers.

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Journal Article↗
PubMed1991

[Clinical study of liver alveolar hydatid disease].

113 patients with liver alveolar hydatid disease confirmed by laparotomy were analyzed. The patients were found in epidemic areas; this factor was considered in the diagnosis of the disease. Digestive tract symptoms and right epigastric mass, usually as firm as a stone, were the commonly seen clinical features. Many patients suffered from light anemia and hepatosis. Casoni test and PPA-ELISA were positive in 85.84% and 100% of the patients respectively. B-ultrasonography was most useful diagnostic means with characteristic wave shape and figure, and the diagnosis was confirmed by laparotomy in 93.18% of the patients. Most lesions were single large-well-circumscribed masses (53.93%); nodular lesions and mixed type lesions were found in 29.2% and 16.81% of the patients respectively. Radical resection was performed in 20 patients (17.7%), 85% of the patients were cured. Symptoms were relieved in 75% of the late-stage patients undergoing tumor excavation and drainage plus pharmacotherapy. Patients treated by albendazole, medicinal herbs, or both showed similar effective rates of 86.37%, 90%, and 88.23%, respectively (P greater than 0.05).

Adolescent↗