Search PubMed⌕ Search

Biomedical subjects

Y Miyoshi

Publications and source records attributed to Y Miyoshi.

330 records · Page 19Linked to original sources
PubMedDate not supplied

Nasal mucociliary clearance under various conditions.

We applied the tagged-particle method or the saccharin method or both to the nasal mucociliary clearance. There was no effect of ageing on the transport time of saccharin in control subjects of ages under 60, and 70% of control subjects of ages more than 60 had the same transport time as that obtained in younger control subjects. The significant inverse correlation between the mucociliary transport rates with the particle method and the transport time with the saccharin method were established in control subjects, but not, however, in patients with chronic sinusitis. The mucociliary transport rates were measured under non-physiologic conditions of the nose: laryngectomy, chronic sinusitis, Sjögren's syndrome, and Kartagener's syndrome.

Adolescent↗
PubMedDate not supplied

Lysosomal thiol proteases (cathepsin B-like proteases) in serous middle ear effusions from adult patients.

Hydrolytic activity of cathepsins B, H and trypsin-like proteases was measured in 38 serous middle ear effusion (MEE) samples. The concentrations of (alpha 1-AT) and alpha 2-macroglobulin (alpha 2-M) were also quantitated. The mean value of cathepsin B activity was 25.0 +/- 20.7 RFU and that of cathepsin H was 14.3 +/- 3.0--both significantly higher than those in plasma (1.8 +/- 0.4 RFU, 1.2 +/- 0.3 RFU, p less than 0.005). Very low trypsin-like protease activity could be observed. The mean concentrations of alpha 1-AT and alpha 2-M were 368 +/- 94.8 mg/dl and 57.5 +/- 57.3 mg/dl. The bulk of alpha 1-AT in MEEs was occupied by free alpha 1-AT, which can saturate exogenous trypsin. Due to the very low molar concentration of alpha 2-M in MEEs, thiol proteases (mainly cathepsin B) could be a possible major factor inflicting proteolytic injury on the middle ear mucosa and reflecting the severity of the inflammatory process.

Adult↗
PubMedDate not supplied

Activities of antiplasmin and antiplasminogen activator in serous middle ear effusions.

Antiplasmin and antiplasminogen activator activities in serous middle ear effusion (MEE) collected from adult patients were measured to analyze the kinetics of antifibrinolytic activity of protease inhibitors. No trypsin, plasmin, and plasminogen activator (PA) activity could be detected in the pooled serous MEE by either the fibrin plate method or the fluorometric assay. Antiplasmin activity in serous MEE was lower than that in plasma. The MEE had no antiurokinase activity. These findings indicate that 1) serous MEE has residual antifibrinolytic activity which may be attributed to mainly antiplasmin activity of unsaturated plasmin inhibitors and not to anti-PA activity, and 2) that serous MEE contains no secretory urokinase inhibitors.

Adult↗
PubMedDate not supplied

Asymptomatic extrahepatic portal obstruction without portal hypertensive findings detected in ultrasonic mass screening.

BACKGROUND/AIMS: We report three adult cases of extrahepatic portal obstruction (EHPO) detected by ultrasonic (US) mass screening. MATERIAL AND METHODS: All these cases were asymptomatic with no abnormalities on hematological or biochemical tests. Only indocynanine green clearance test revealed a slight abnormality. By imaging modalities, the portal trunk could not be visualized and cavernous transformation could be visualized. RESULTS: There were no findings of portal hypertension, such as splenomegaly, esophageal varices and hepatofugal collaterals, in any of these cases. CONCLUSIONS: As many EHPOs without symptoms can be detected on US mass survey, US is considered to be the best modality for screening for this disease.

Adult↗