Biomedical subjects
Publications and source records attributed to Y Miyata.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
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The Japanese version of the morningness-eveningness questionnaire and life habits inventory were administered to approximately 400 workers and the changes in morningness-eveningness scores and sleep-wake habits with aging were investigated. All subjects were divided into four age groups, i.e., 20's, 30's, 40's, and 50 + 60's. Morningness-eveningness scores significantly shifted to morningness preference with increased age. The results of sleep-wake habits showed that 1) there were no age-related changes for habitual sleep parameters (bedtime, arising time, and sleep length), but preferential bed and arising times significantly advanced with aging, 2) the variability of habitual sleep parameters were greater in the young than in the old, especially, on the weekend, and 3) the older the age groups were, the better the mood on arising. These findings suggested that the circadian phase was advanced and/or the period was shortened with increased age.
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A multi-institutional prospective study to evaluate the relief of symptoms for patients with osseous metastasis treated with irradiation and methylpredonisolone was performed. A total of 38 patients with osseous metastasis, treated between January 1991 and December 1992, were included in this study. Patients were randomly allocated to one of two treatments: radiation alone (RT alone) (n = 18) or radiation combined with methylpredonisolone (RT + MP) (n = 20). Symptoms were scored by patients themselves using original Quality of Life (QOL) scores. Stratification by urinary hydroxyproline/creatinine ratios (Hypro/Cr) showed no significant differences in QOL scores between RT and RT + MP in the group with good prognosis, which showed a lower Hypro/Cr (< 3.6 mg/g) during treatment. Following treatment, the score for both groups improved. On the other hand, in the group with poor prognosis, with a higher Hypro/Cr (> or = 3.6 mg/g), a significantly greater improvement in QOL scores was observed for the RT + MP group than for the RT alone group (p < 0.05). There was also a marked difference in the RTOG pain scores, evaluated by physicians before treatment and at the end of treatment, between the two treatment groups and the prognostic groups divided according to Hypro/Cr. No correlation was seen at initial presentation between urinary Hypro/Cr and serum tartrate-resistant acid phosphatase (TrACP). In conclusion, the treatment regimen of RT + MP is recommended for patients with osseous metastasis with poor prognosis who show relatively high Hypro/Cr values. Radiotherapy was equally effective in terms of RTOG pain score for both the poor and good prognostic groups. Serum TrACP was not useful for determining the prognosis of our patient groups.