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Biomedical subjects

Y Minowa

Publications and source records attributed to Y Minowa.

24 records · Page 2Linked to original sources
PubMed1983

Alteration of strial capillary transport in kanamycin-treated guinea pigs.

Ferritin transport through the strial capillary during kanamycin intoxication was examined under a transmission electron microscope. Twelve guinea pigs were treated intramuscularly with kanamycin (400 mg/kg/day) for 2-3 weeks. When full hearing loss was recognized by estimating the Preyer reflex or auditory brain-stem response (ABR), ferritin was given intravenously and animals were sacrificed 1/3, 1, and 2 h later. At 1/3 h, ferritin was present diffusely not only in the endothelial cell but also in the basal lamina and within vesicles in the strial cell. Alternatively, it was discharged into the endolymphatic space. At 2 h, ferritin was seen on the luminal surface and in the cytoplasm of the endolymphatic cells of Reissner's membrane. These results suggest that the basal lamina of the strial capillary was altered qualitatively by kanamycin administration.

Animals↗
PubMed1983

Enhancement of ciliary action by a beta-adrenergic stimulant.

It is known that beta-adrenergic stimulants enhance mucociliary transport in the respiratory tract. The present study clearly indicated that such an enhancement resulted from not only the alteration in secretory function but also the direct stimulation of ciliated cells. However, the enhancement of ciliary beating depended on the morphological changes in ciliated cells. On the other hand, the effect of terbutaline aerosol, a beta-adrenergic stimulant, on patients with chronic sinusitis was evaluated by paranasal sinus radiography. Consequently, marked improvements in shadows were achieved after 4 weeks in 40% of the cases examined.

Adult↗
PubMed1982

Ototoxicity of the anticancer drug cisplatin. An experimental study.

Cisplatin was administered to guinea pigs. Hearing function was tested using ABR, and morphological studies were conducted by scanning and transmission electron microscopy. The following findings were made. (1) The susceptibility to cochlear damage by cisplatin was dose dependent. (2) At the same dose, damage was most severe in the lower turns, particularly in the second turn. This tallies with the high tone loss. (3) Mainly the outer hair cells are the site of the damage and the inner hair cells are rarely damaged. (4) The first row of the outer hair cells tend to be more severely damaged. (5) Variation of the stria vascularis was moderate compared with the damage to the organ of Corti. (6) A tendency of recovery was observed in ABR in some animals after they were given 2 mg/kg/day cisplatin intramuscularly consecutively for 8 days.

Animals↗
PubMedDate not supplied

Application of loop diuretics for treatment of sensorineural hearing impairment. Experimental and clinical study.

In a series of animal experiments on guinea pigs and rats, conducted in an attempt to find a better solution for the treatment of sensorineural hearing impairment and tinnitus-known as diseases almost impossible to heal-it was revealed electrophysiologically, biochemically and electronmicroscopically that loop diuretics, referred to as ototoxic drugs, cause an increased amount of the therapeutic preparation to transfer to the inner ear fluid. It is concluded, on the basis of the encouraging results of these experiments, that combined medication with metabolic activator, steroid hormone and loop diuretics is significantly more effective in improving the symptoms of patients with inner ear deafness and tinnitus.

Animals↗
PubMedDate not supplied

Value of low-dose gallium-67 imaging in detection of non-Hodgkin's lymphoma recurrence.

We evaluated the usefulness of low-dose Ga-67 scintigraphy as a diagnostic tool for the detection of non-Hodgkin's lymphoma recurrence. Forty-six patients were included in this retrospective study. Anterior and posterior whole body images were obtained two or three days after the injection of 74 MBq of Ga-67. Inter- and intraobserver variability in scintigraphic imaging interpretation was analyzed using the kappa (kappa) statistics. Ga-67 scintigraphy allowed correct detection of recurrence in 18 of 22 events (sensitivity, 82%), and excluded relapse in 34 of 39 events (specificity, 87%). The positive predictive value was 0.78 and negative predictive value 0.89. All cases involving superficial lymph nodes (10/ 10) could be detected by Ga-67. Chest lesions were diagnosed with a sensitivity of 86% (6/7), bone and soft tissue 83% (5/6), and abdomen 80% (8/10). The sensitivity and specificity of CT were 91% (22/24) and 67% (8/12), respectively. In abdominal lesions, ultrasonography had sensitivity and specificity of 93% (14/15) and 94% (15/16), respectively. Kappa (kappa) statistics demonstrated good to strong inter- and intraobserver agreement in the interpretation of Ga-67 scintigraphy. The diagnostic results of low-dose Ga-67 scans, currently applied in Japan, were similar to those reported by the authors using high doses of 296 MBq to 370 MBq. Ga-67 scintigraphy, even at low dose, is useful in the detection of non-Hodgkin's lymphoma recurrence.

Adult↗