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Biomedical subjects

Y Minaire

Publications and source records attributed to Y Minaire.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Amylase-creatinine clearance ratios in burned patients (author's transl)].

The amylase/creatinine clearance ratio (ACCR) has been examined every 3 days, in 34 burned patients during the 20 days following the accident. This ratio was often abnormal since it was found increased at least on one occasion, in 75% of these patients, to be compared with 23 and 13% for amylase in serum and urine respectively. In another group of 9 burned patients, the ACCR was monitored for time-period between 10 to 52 days. It was observed that a high frequency in increased ACCR was associated with a fatal outcome. Finally simultaneous measurements of ACCR and of the beta2 microglobulin/creatinine clearance ratio (MCCR) showed that increased ACCR were statistically associated with increased MCCR suggesting a decreased renal tubular reabsorption of low molecular weight proteins in these burned patients.

Amylases↗
PubMed1978

Uneven and transient secretin release after a liquid test meal.

In order to test the hypothesis that secretin may be released intermittently after feeding, the plasma secretin concentration was measured at short intervals, and the duodenal pH continuously recorded, after a liquid test meal in 10 human subjects. Secretin was measured with a radioimmunoassay in which the entire molecule is specifically recognized and the immunoreactivities of human secretin and of the porcine peptide used as standard are similar. In the total group, no significant variation of the mean plasma secretin concentration above basal was observed within 45 min after feeding. Analysis of the individual patterns revealed that secretin was released transiently in 5 of the 10 subjects, namely those showing variations of the duodenal pH down to or below 4.0 at some time after the meal. The mean peak delta secretin in these subjects was 7.2 pg ml-1 of plasma. In 7 additional subjects, bolus intravenous injections of 0.005 and 0.01 clinical units kg-1 of porcine secretin resulted in peak delta secretin concentrations of 5.5 and 10.5 pg ml-1, respectively, and were followed by a significant increase of bicarbonate output in the duodenal aspirate. These results indicate that secretin is released unevenly and intermittently in the early period after a liquid meal in man, in amounts that seem sufficient for the initiation of a significant bicarbonate response.

Adult↗
PubMed1977

Effect of epinephrine upon irreversible disposal and recycling of glucose in dogs.

Irreversible utilization and recycling of glucose during epinephrine-induced hyperglycemia were studied in adrenal-demedullated dogs exposed to neutral or cold ambient temperature. Whatever the ambient temperature, most of the extra glucose mobilized by epinephrine is recycled rather than irreversibly utilized by the peripheral tissue.

Adrenalectomy↗
PubMed1977

Tolerance to cold and glucose homeostasis in adrenal demedullated dogs.

The rise in O2 consumption and in glucose turnover, induced by acute cold exposure is not suppressed by adrenal demedullation in dogs. However, both at neutral and cold ambient temperature, the mean plasma glucose concentrations are higher in normal (N) than in adrenal-demedullated dogs (ADMX). In the cold, the fall in rectal temperature is larger in ADMX than in N dogs.

Acclimatization↗
PubMed1977

Comparison of caerulein and cholecystokinin effects upon enzyme concentrations in duodenal aspirates.

The effect of maximal doses of cholecystokinin and caerulein on lipase and chymotropsin concentrations were compared in large groups of patients with almost equal capacities of bicarbonate secretion. The responsiveness of the pancreas is, as a whole, higher with caerulein than with cholecystokinin, this feature being specially evident in patients with chronic calcifying pancreatitis.

Bicarbonates↗
PubMed1977

Exocrine pancreatic insufficiency and primitive malnutrition.

Pancreatic function tests were performed before and after dietary therapy in four patients suffering from primitive malnutrition. Maximal bicarbonate concentrations and lipase activity were the parameters most clearly affected by malnutrition and those showing the fastest recovery following therapy. With reference to this quick recovery it seems unlikely that, at least in Western countries, malnutrition could be a cause of chronic pancreatitis. Interpretation of pancreatic function tests requires an exact knowledge of the nutritional status.

Adult↗
PubMed1976

Reversible and irreversible glucose disposal in dogs: influence of fasting and cold exposure.

Rates of total glucose entry rate, irreversible loss, and recycling were measured in unanesthetized dogs with indwelling arterial and venous catheters. Four experimental conditions were selected: 16 or 26 hr of fasting and neutral (+25 degrees C) or cold (-21 degrees C) ambient temperatures. A mixture of U 14C-glucose and 2-3H-glucose was used as a tracer, according to the primed infusion technique. No matter what the ambient temperature was, increase of fasting time from 16 to 26 hr induced a slight, but nonsignificant, decrease in both the total glucose entry rate and the irreversible loss. At neutral ambient temperature, the amount of glucose promptly recycled was less after 16 hr than after 26 hr of fasting, while an opposite pattern was observed during cold exposure. Thus, that part of hepatic glucose entry promptly recycled was significantly increased from 22% (16 hr of fasting) to 31% (26 hr of fasting) at neutral ambient temperature. It remained almost unchanged (20% and 18%) in cold. It was, therefore, suggested that this increase might be considered as an compensatory mechanism, exerting a sparing effect on glucose utilization. This mechanism does not occur in cold ambient temperature, thus, worsening a possible shortage in glucose supply.

Animals↗
PubMed1975

Chronic pancreatitis, alcoholic liver cirrhosis and salivary secretion.

By comparison with control subjects, patients with chronic pancreatitis and alcoholic liver cirrhosis displayed in basal condition a reduction in salivary volume, bicarbonate and an amylase concentration and outputs. These reductions disappeared during stimulating by chewing parafilm. It is concluded that these reductions are not the consequence of a specific process affecting both the salivary glands and the pancreas. It is suggested that they are more likely due to a decreased sensitivity of the salivary nervous control than to an actual alteration in the secretory capacities.

Alcoholism↗