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Biomedical subjects

Y Meng

Publications and source records attributed to Y Meng.

At least 91 records · Page 5Linked to original sources
PubMed1995

[Pharmacokinetics study of intraperitoneal carboplatin in gynecologic carcinoma].

Twenty patients with surgically and pathologically confirmed gynecologic cancer from December, 1991 to December, 1992 were treated by intraperitoneal (i.p.) chemotherapy with carboplatin in 15 and by intravenous (i.v.) chemotherapy with carboplatin in 5, patients had normal hepatic and renal function test and were nonsmoker. Using Grathite atomic absorption spectrum method, total mean maximal plasmic carboplatin concentration in the cases by intravenous infusion was 8 times greater than those by intraperitoneal infusion. The half-life of plasmic elimination in the cases treated by i.v. infusion and by i.p. infusion were respectively 10.82 +/- 4.95 hours and 54.04 +/- 10.75 hours (P < 0.05). But total carboplatin plasmic clearance in the cases were 1.88 +/- 0.53 ml/min and 1.12 +/- 0.58 ml/min, respectively (P < 0.05). Pharmacokinetic profiles suggest a possible therapeutic advantage by giving the drug intraperitoneally for the treatment of tumour nodules situated in the peritoneum. This research also suggest the method has the possibility in increasing antitumn effect and decreasing bone marrow in intoxication because of the wide distribution, low plasmic concentration and slow clearance of drugs.

Adult↗
PubMed1995

[Study of autologous bone marrow transplantation in the treatment of gynecologic carcinoma].

OBJECTIVE: To investigate the role of autologous bone marrow transplantation (ABMT) in patients with gynecologic carcinoma treated by high-dose chemotherapy. METHODS: This was a presentation of four patients with ovarian carcinoma, two patients with primary fallopian tubal carcinoma, and 5/6 of them clinically staged as III and IV, treated with combination chemotherapy of cytoxan and carboplatin by intraperitoneal and intravenous infusion, the dose being 2.5-5 times those employed conventionaly. Autologous bone marrow collection and storage were conducted under strictly sterile conditions. Chemotherapy was given pre- and post-operatively and ABMT was performed immediately after chemotherapy. Careful follow-up was observed at monthly intervals. RESULTS: All of the six patients tolerated the treatment well, with no death within a median follow-up of 26 months (range 1532). Five of them lived more than 6 months with no evidence of disease. Two patients without gross residual tumor, who could not tolerate conventional chemotherapy which had to be discontinued, successfully received high-dose chemotherapy, supported by ABMT. All four patients with gross residual tumor benefited by immediate clinical remission after treatment. Median survival for all patients was 28 months (range 1253), median survival for stage IV patients was 24 months (range 1230). CONCLUSIONS: Patients subjected to high-dose chemotherapy supported by ABMT are exempted from suffering the cyclic multiple courses of chemotherapy, repeated or long-term hospitalization and may lead a life of good quality.

Adult↗
PubMed1995

[A study on stretching capacity of continuous circular capsulorhexis and nucleus delivery].

The stretching capacity of continuous circular capsulorhexis (CCC) in 20 human cadaver eyes was determined. The increases in circumference of the tear opening ranged from 164. 5% to 190.9% and that in area of the opening ranged from 235.2% to 364.6%. If a proper technique of capsulorhexis is adopted, the nucleus of 7-9.5 mm in diameter and 3-4.5mm in thickness can be delivered through a CCC opening of 4-6mm in diameter by hydrodissection and hydroexpression of nucleus without capsular tear.

Adult↗
PubMed1994

Dynorphin A-(1-13)-morphine interactions: quantitative and qualitative EEG properties differ in morphine-naive vs. morphine-tolerant rats.

The effects of dynorphin A-(1-13) on cumulative IV morphine-induced EEG and EEG power spectra were studied in naive and morphine-tolerant rats. Adult female Sprague-Dawley rats were implanted with cortical EEG electrodes and permanent indwelling ICV and IV cannulae. In naive rats, dynorphin A-(1-13) quantitatively decreased cumulative IV morphine-induced EEG spectral power as well as qualitatively shifting the relative distribution of spectral power to predominantly faster frequencies. In morphine-tolerant rats, the quantitative and qualitative EEG properties were identical to those in dynorphin A-(1-13) pretreated morphine-naive rats. Thus, dynorphin A-(1-13) pretreatment apparently produced instantaneous acute morphine tolerance. Furthermore, in morphine-tolerant rats, dynorphin A-(1-13) pretreatment quantitatively increased morphine-induced EEG power without qualitatively changing the relative distribution of EEG spectral power. This latter effect may be due to a summation of increased endogenous levels of dynorphin A-(1-13) associated with the development of morphine tolerance and the experimentally administered dynorphin A-(1-13). These results indicate that dynorphin-induced quantitative and qualitative EEG changes of morphine may reflect different underlying processes. That is, quantitative changes may reflect the number of receptors that are activated, while qualitative changes may reflect the nature of the receptor-effector coupling.

Animals↗
PubMed1994

[An orthogonal method for comparing extracting techniques of licorice root extract].

A L9(3(4)) form developed by the orthogonal method was used to study the size, extraction solvent and extraction frequency of licorice root extract, and taking the recovery of glycyrrhizic acid as the criteria, a comparison was made on the different ways of extracting the herb. The result showed the glycyrrhizic acid could be recovered over 10% (about 7% higher than that from water treatment) when the herb was cut into pieces and then extracted by fluxing for 3 times with 60% alcohol containing 0.3% ammonia.

Drugs, Chinese Herbal↗
PubMed1993

Requirement of cellular uptake for adenosine inhibition of p-nitrophenol glucuronidation in isolated rat hepatocytes.

Adenosine (ADO) has been shown previously to inhibit p-nitrophenol glucuronidation in a concentration-dependent manner when concurrently incubated in isolated rat hepatocytes for 30-60 min. In the current study, preincubation of ADO (500 microM) in isolated hepatocytes for 30 min prior to addition of 100 microM p-nitrophenol resulted in a greater inhibition of glucuronidation when compared to that without preincubation (80 vs 50% inhibition). The inhibitory effect of 250 microM ADO on glucuronidation was decreased from 60 to 10% in the presence of the ADO transport inhibitor nitrobenzyl thioinosine during the 30-min preincubation period. Without prior incubation, 100 microM dibutyryl cyclic AMP (DBcAMP) produced an inhibition of glucuronidation similar to that of 500 microM ADO. In contrast to ADO, there was no significant difference in the inhibitory effect of DBcAMP on p-nitrophenol glucuronidation with or without a 30-min preincubation. Thus, DBcAMP and ADO appear to inhibit glucuronidation through different mechanisms. Furthermore, these results indicate that the inhibitory effect of ADO on p-nitrophenol glucuronidation is dependent to a large degree on the cellular uptake of ADO into hepatocytes, while a portion of the inhibitory effect may arise from the generation of intracellular cyclic AMP.

Adenosine↗
PubMed1993

Jaw movements and EMG activities of limb-licking behavior during grooming in rabbits.

Jaw movements and masticatory muscle activity were recorded in freely moving rabbits during limb-licking, chewing, and drinking. The limb-licking movement was characterized by rhythmical jaw movement and digastric burst and relatively small masseter activity. The mean cycle time was 292 ms +/- 11.0 (mean +/- SE: n = 7) and was longer than that in chewing (267 ms +/- 20.8, p < 0.01) or drinking (208 ms +/- 15.2, p < 0.01). Jaw movements in the frontal plane of the ingestive behaviors coincided with those reported in previous studies; however, that of the licking movements was featured here. The basic cycle included; a) an opening stroke in which the mandible moved downward and laterally, b) a lateral excursion stroke in which the mandible moved medially and either upward or downward, and c) a closing stroke in which the mandible moved upward to the closing position. During opening, the digastric activity on the working side was determined to be larger than that on the other side (p < 0.001).

Animals↗
PubMed1992

Introduction of the ras oncogene transforms a simian virus 40-immortalized hepatocyte cell line without loss of expression of albumin and other liver-specific genes.

Activated c-Ha-ras DNA sequences were introduced by transfection into a low passage simian virus 40 (SV40)-immortalized rat hepatocyte cell line, CWSV1, and stable ras transfectant cell lines were established to determine the effect of the addition of the activated c-Ha-ras oncogene on growth properties and differentiation. Control transfectant cell lines were generated by transfection with neo alone. CWSV1 cells at low passage and the control transfectants were not tumorigenic. The ras transfectants demonstrated anchorage-independent growth and were highly tumorigenic in syngeneic hosts. CWSV1 cells produce liver-like levels of albumin and express other liver-specific genes. The ras transfectants expressed RNA for albumin, transferrin, and the transcription factor HNF-1 at similar levels to the parental CWSV1 cells, indicating that the alterations in growth properties and tumorigenic potential of these cells did not decrease the ability of the cells to express several genes that are associated with hepatocyte differentiation. The addition of the ras oncogene did not induce the expression of alpha-fetoprotein and had no specific effect on expression of glutathione S-transferase-P. The tumors produced by the ras transfectants were not well differentiated; however, the cells in the tumors and tumor cell lines derived from the tumors continued to produce albumin and did not produce alpha-fetoprotein. We conclude that the addition of the activated c-Ha-ras oncogene to immortalized CWSV1 cells transformed these cells as measured by morphology, growth properties, and tumorigenicity without reducing their ability to express albumin and other significant liver-specific genes.

Animals↗
PubMed1990

[Chemical constituents of Agapetes obouata S. H. Huong].

Six compounds were isolated from Agapetes obouata. On the basis of physico-chemical constants and spectral analysis they were identified as friedelin (I), fernenal (II), beta-sitosterol (III), daucosterol (IV), beta-sitosterol glucutonide (V) and n-tridecane (VI) respectively.

Drugs, Chinese Herbal↗
PubMed1990

[Anatomy and microstructure of the disco-malleolar ligament].

The disco-malleolar ligament was studied with the method of the anatomy and histology, and it's function was observed in the living people. It was found that the ligament takes its origin from the neck and anterior process of the malleus in middle ear and inserts into the capsule and meniscus of the temporomandibular joint. Part of the fibers was mixed with the spheno-mandibular ligament and attaches on the lingula of the mandible. The disco-malleolar ligament consists of collagenous fibers and elastic fibers. A peri-ligamentous space exists between the ligament and bone tissue. It was found the tympani membrana light cone area became smaller in opening position and larger in closing position. The existing peri-ligamentous space of the disco-malleolar ligament is a latent way between temporomandibular joint rear and tympanum.

Cephalometry↗
PubMed1984

Cancer in the gastric remnant in China--a review of 33 cases in China.

A review of 33 cases of cancer in the gastric remnant (CGR) including 6 cases in Xian is presented. The detection rate of CGR consisting of different interval groups was 3.16%. The average age was 52.4 years, and Male: female ratio was 10:1. The average interval from the previous operation to the detection was 13.9 years. The interval of the subgroup over 30 years of age at the first operation was shorter than that of the subgroup below 30 years. The highest incidence was found in anastomotic stoma (58.1%) and cardia (32.3%). Borrmann I was the most common pathological type. Confirmed diagnostic rate with fibergastroscope was 81.8%. It is imperative that physician should follow up the patients with stomach remnant. No matter what the results of gastrointestinal barium study may be, the patients should undergo fibergastroscopic examination. The pathogenesis of CGR is also discussed.

Adenocarcinoma↗