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Biomedical subjects

Y Maugars

Publications and source records attributed to Y Maugars.

At least 73 records · Page 4Linked to original sources
PubMed1993

[Extramedullary hematopoiesis. An unusual cause of Pagetic spinal cord compression].

An original case is reported: spinal cord compression due to extramedullary hematopoiesis of the epidural space, related to Paget's disease of bone, successfully treated by surgery. Extramedullary hematopoiesis, usually occurring in cases of hematological disease, can also complicate Paget's disease, probably by bone effraction mechanism. A review of literature has found 5 other cases of extramedullary hematopoiesis occurring in Paget's disease, without hematological disease. Medullar scintigraphy (Indium111, Technetium99 Sulfur colloid) can confirm the diagnosis after X-ray findings, without the need for biopsy. Awareness knowledge of this complication can sometimes avoid invasive investigation. Low dose radiotherapy is useful in the case of hematological disorders. In Paget's disease, there is a risk of sarcomatous degeneration. In our patient, surgery cured cord compression, but it relapsed because of extensive fibrosis, in complicating surgical hemorrhage.

Aged↗
PubMed1992

Corticosteroid injection of the sacroiliac joint in patients with seronegative spondylarthropathy.

OBJECTIVE: We report our experience with the use of corticosteroid injections into the sacroiliac joint in the treatment of patients with seronegative spondylarthropathy. METHODS: We performed 42 injections, constituting 24 procedures in 22 patients (2 patients had the procedure performed twice). RESULTS: The response was considered very good or good in 19 of 24 procedures (79.2%) and 34 of 42 joints (81%). Improvement persisted in 14 patients after a mean +/- SD followup time of 9.6 +/- 4.2 months. CONCLUSION: This technique appears to be safe, easy to apply into ambulatory patients, and quite effective.

Adolescent↗
PubMed1991

[Study of bone repercussion in 33 cases with anorexia nervosa which 8 with fracture osteoporosis].

A national survey has regrouped 33 cases of anorexia nervosa (AN) with osseous investigations, in particular an absorptiometry of the lumbar spine. 2 groups have been defined: 25 patients without fracture (F-) and 8 patients with osteoporotic fractures (F+), including 5 cases with 12 vertebral fractures and 5 with non vertebral fractures: 31/33 have a low lumbar bone mineral content (BMC). The lumbar BMC of the F+ is significantly lower than the F-: -4.1 +/- 1.6 DS versus -2.2 +/- 1.2 DS (p less than 0.001). 5 F+ patients are under the fracture threshold (FT), (O F-), 2 F+ are on the same level as the FT, and the last F+ has a lumbar BMC 15% above the FT, but an osteoporotic wrist fracture and a very low femoral neck BMC (0.64 g/m2, normal 1.06 +/- 0.15). F+ are older (35.2 year old versus 23.6, p less than 0.001), owing the fact that the duration of the AN (+ 9.2 years, p less than 0.005) and of the amenorrhea (+ 9.8 years, p less than 0.001) are longer, although the AN began at the same age in the 2 groups. The minimum weight, the body mass index, the percentage of loss of weight are similar in the 2 groups. Phosphocalcic biological studies, which show rather high osteocalcinemia and hydroxyprolinuria (hyperremodeling), with rather high serum 1-25 OH vitamin D, do not differ between the 2 groups. Endocrinologic evaluations, with a constant hypooestradiolemia of hypothalamic origin, low somatomedinemia and normal cortisolemia, are not different between the 2 groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Absorptiometry, Photon↗
PubMed1991

[Parosteal sarcoma of the radius in the course of etretinate therapy].

A parosteal osteosarcoma of the right radius has developed in a patient treated for a long time by etretinate (total dose: 73 g). If brachial ossifications have been reported to etretinate in 2 cases, they were benign tumours; so coincidence is possible in our case. Nevertheless, a relation between the tumour and the treatment cannot be excluded and justify the report of this observation.

Bone Neoplasms↗
PubMed1988

[Tiopronin in 69 cases of rheumatoid polyarthritis treated earlier with D-penicillamine].

This study concerns 69 patients with rheumatoid arthritis (RA) and having received successively D-penicillamine (DP) then, after a mean period of 2 years, tiopronin (TP) at a daily dose of 1,500 mg. TP demonstrated an as frequent, as marked, and as prolonged effectiveness as that of DP. 28 patients are still under TP treatment, with a mean length of treatment of 43.7 months. The rate of effectiveness of TP was similar, whether or not the response to DP was favorable: 64.1 and 64.3 p. cent respectively; 72.4 p. cent of the 29 cases which did not respond to DP, responded favorably to TP. The manifestations of intolerance to TP were similar in nature (including the first reported case of obstructive bronchiolitis) and frequency to those observed with DP. There were only a few manifestations of crossed intolerance: the rate of TP discontinuation because of intolerance was the same, whether the DP was well tolerated (29.6%) or discontinued because of poor tolerance (30%). The same undesirable effect was only observed in 4 cases: one case of pemphigus, another case of toxic dermatitis, 2 proteinurias. This study confirms that TP represents a new, major long-term treatment of RA and demonstrates that this very product is an excellent take over medication.

Adult↗
PubMedDate not supplied

[Paraneoplastic dermatopolymyositis].

In a retrospective study covering 11 years, 59 adult cases of dermatomyositis or polymyositis were reviewed. The disease was of paraneoplastic origin in 9 cases (15,25 p. 100), the same proportion as that found in the literature (14,6 p.100). The striking female predominance (8/9 cases) and the patients' mean age (61.11 years) were higher than those noted in non-paraneoplastic dermato- and polymyositis in adults (female predominance 34/50, mean age 52.9 years). Clinically, out of 9 patients 7 had dermatomyositis and 2 had polymyositis. The disease was discovered at the same time as the neoplasia in 7 of the 9 cases. Muscle histology showed that in contrast with non-paraneoplastic cases of dermatomyositis-polymyositis those of paraneoplastic origin had moderate lesions without fibrosis.

Aged↗
PubMedDate not supplied

[Awareness of 125 patients of the rules for using their non-steroidal anti-inflammatory agent].

A total of 125 inpatients from a rheumatology unit were interviewed to assess their awareness of the rules for using a prescribed NSAID. Two per cent were unaware that they were receiving an NSAID, and 13 per cent and 71 per cent respectively did not know the name or the dosage. Twenty-two per cent admitted excessive intake, and 2 per cent simultaneous intake of two NSAIDs. Some declared that in the absence of adequate improvement they would take another NSAID (17 per cent) or aspirin (26 per cent) simultaneously. Fifty-nine per cent were unaware that aspirin is an anti-inflammatory drug, 3 per cent thought that taking a double dosage on alternate days was safe, and 46 per cent that taking a stronger dose at the beginning of treatment was an efficient and safe procedure. The replies of patients who had read the directions for use (69 per cent) did not differ from those of patients who had not (31 per cent). Fourteen per cent of patients declared that they would not advise their physicians after buying NSAIDs over the counter.

Adult↗
PubMedDate not supplied

[Chronotherapy of tenoxicam].

A study was carried out in order to investigate the chronotherapy (dosing time dependency) of an NSAID, the tenoxicam administered in ankylosing spondylitis, rheumatoid arthritis and osteoarthritis of the hip. These variations in efficacy exist as much for pain as for stiffness and maximum efficacy is obtained with administration at 8 am or 12 pm. Since the tolerance was good, we recommend midday as an optimal once-a-day dosing time.

Adult↗
PubMedDate not supplied

[Air pouch model in the rat for evaluating articular phlogogenic capacity of ceramics].

We used the joint air pouch model in rats to study the inflammation induced by three types of calcium phosphate biomaterial: 10 mg of synthetic hydroxyapatite (HA), a sintered ceramic made of hydrooxyapatite and phosphate tricalcium (BCP), and calcium phosphate in the form of a fibre extracted from a vitro-ceramic material (VPC). Histological examination was made after 48 hours. The most intense inflammatory reaction was observed with BCP: the thickness of the superficial stratified layer of synoviocyte-like cells doubled, interstitial fibrosis occurred and neovascularization with polymorphous inflammatory infiltration was seen. HA led to the same, though less intense, type of reaction. Discrete, variable, localized inflammation was seen with VPC and was limited to the areas where the calcium phosphate fibres rolled. Despite good bone tissue tolerance, intraarticularly, these biomaterials can lead to synovial inflammation. This phlogogenic action varies greatly depending on the microcrystals injected. The factors which might affect the joint inflammatory reaction, including the size and surface of the microcrystals, the crystallinity, pH and physical treatments (heat, compaction) should be further evaluated with precision.

Animals↗
PubMedDate not supplied

Antiperinuclear factor of the IgA isotype in active rheumatoid arthritis.

OBJECTIVE: For rheumatoid arthritis (RA), antiperinuclear factor (APF) is as efficient a marker as rheumatoid factor (RF). However, the prevalence and significance of APF of the IgA isotype in active RA, as well as its correlation with RF-IgA, have not been determined. Our goal was to obtain information on these points. METHODS: APF-IgA were screened in 80 sera from patients with active RA, prospectively and consecutively selected over an 8-month period. Sera from 22 patients with Sjögren's syndrome and 50 with lupus were also studied retrospectively for APF-IgG and IgA. RESULTS: APF-IgA were found at a 1:10 dilution or above in 31 RA sera (39%), which were all positive for APF-IgG as well at higher titers. In the 64 sera positive for APF no correlations were found between APF-IgA and IgA or immune complexes-IgA, latex, the Rose-Waaler test and RF-IgA. Conversely, an association of APF-IgA was found with both APF-IgG (p < 0.0001) and anti-stratum corneum of rat esophagus (ASC)-IgG (p < 0.0001). APF-IgA, though correlated with the presence of secondary sicca syndrome in RA (p = 0.0023), was not more frequent (5/22) in primary Sjögren's sera. CONCLUSIONS: RF-IgA and APF-IgA are not correlated. Despite its localization in the mucosae, the target antigen for APF elicit fewer IgA antibodies in RA than does the RF target.

Adult↗