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Biomedical subjects

Y Matsukado

Publications and source records attributed to Y Matsukado.

At least 127 records · Page 7Linked to original sources
PubMed1983

Prolactinoma of pituitary with associated amyloid-like substances. Case report.

A prolactin-secreting pituitary adenoma containing amyloid substance was studied by light and electron microscopy. The tumor was found in a 32-year-old woman who presented with a short history of amenorrhea and galactorrhea. Pituitary adenoma containing amyloid substance is a very rare entity, and the implications of this association are discussed. Previous reports, suggesting that mesenchymal cells or hormone-secreting tumor cells in pituitary adenomas produce amyloid substances, are reviewed.

Adenoma↗
PubMed1983

[Physiologic significance of F wave in spastic paralysis in the diseases of the cerebral hemisphere].

In order to evaluate physiological significance of F-wave in the diagnosis of spasticity, 10 patients with intracranial mass lesion who did not show clinically lateralizing evidence especially in DTRs were examined and the data were compared with the results obtained from 10 other normal subjects. F-wave was recorded from thenar muscle with supramaximal stimulation to the median nerve at wrist. Latency and amplitude of F-wave failed to show any significant difference in patients compared with normal subjects both on affected sides, however, frequency of F-wave was found to be significantly higher on affected side except for 2 cases who had a mass lesion in occipital lobe in one case and the other was in the state of diaschisis due to recent hemorrhage in the parietal tumor. The site of lesion was carefully determined with CT scan and it was concluded that the F-wave could be detected quite in early stage of intracerebral mass lesion if the process had affected to internal capsule or cerebral peduncle under indirect mass effect such as cerebral edema. On the contrary, it was interesting to note that the mass with no affection to the premotor cortex likely showed higher frequency of F-wave on the ipsi-lateral side of lesion. As the conclusion, F-wave was found to have advantage in the diagnosis of spasticity in the early stage of illness and more accurate information on spasticity could be obtained compared with T or H-wave.

Brain Neoplasms↗
PubMed1983

[Evaluation of blink reflexes in cerebellopontine angle tumors].

Blink reflexes were analysed in 28 cases with cerebello-pontine angle tumors (22 cases of acoustic neurinoma and 6 cases of meningioma). In patients with acoustic neurinoma, delay or absence of R1 was found in all but two cases (91%) and abnormality of R2 was in 11 (50%). Estimating the mean latency difference of R1 on both sides it was found useful for establishing early diagnosis of small acoustic neurinomas, which had no apparent clinical signs of facial or trigeminal nerve involvement. In patient with obsolete hemorrhage (5 cases) or large cyst (6 cases) within the acoustic neurinomas, which were proven at operation, abnormality of blink reflexes was more prominent than in patient with solid tumors (11 cases). In patients with meningioma, although all were huge tumors, abnormality of R1 was less conspicuous in comparison with acoustic neurinoma. Bilateral delay of R2 was found in 3 of 6 patients. In 13 patients who underwent spinal accessory-facial anastomosis for facial palsy after removal of the tumors, R1-like response were recorded in all but one on the affected side and R2-like response was recorded in only one patient. Observing alteration of blink reflexes in patients with cerebello-pontine angle tumor was useful for establishing early diagnosis and evaluating function of trigeminal nerve, facial nerve and brainstem.

Accessory Nerve↗
PubMed1983

[Acromegaly and spinal canal stenosis].

A rare case of acromegaly with radiculomyelopathy due to spinal canal stenosis is reported. A long history of acromegalic deformity was seen on this 55 years old acupuncture therapist for the last 18 years, while he had developed unusually increased appetite, profuse perspiration and gained weight. Fifteen years ago, acromegalic tendency became prominent and was accompanied by low back and knee pain. In 1974 CB-154 was administered in several occasions beside 4000 rads irradiation to the sella. After radiation therapy was completed his outlook was somewhat improved, although low back pain was aggravated and associated with atrophy of the left lower extremity. The neurological examination at admission in 1980 revealed acromegalic feature, increased DTRs on both upper and lower extremities, dysesthesia of feet and atrophy of the leg muscles in general, mainly due to diffuse atrophy. Patient bended knees due to pain and unable to walk. He had radiating pain in the postero-lateral aspect of the left lower extremity and some dysesthesia of feet, although no specific root lesion was identifiable. Spinal roentgenograms disclosed diffuse ossification of anterior and posterior longitudinal ligaments, and marked spondylotic changes. Although the low back pain was impending complaint of the patient, the hypophyseal tumor was advised to remove and transsphenoidal hypophyseal adenomectomy was performed. A good amount of softend tumor tissue was removed however, adenoma found markedly fibrotic. Low back pain and knee were decreased gradually, but intermittent claudication was evident. Acromegaly in association with spinal canal stenosis were reviewed in literature, and the relationship of growth hormone and therapeutic problems were discussed.

Acromegaly↗
PubMed1983

[Intracranial giant osteochondroma with unusual clinical features].

A case of giant osteochondroma arising from the paramedian skull basis was reported because of unsual clinical features in cranial nerve involvement and pyramidal tract signs, and especially because of sudden death due to intracranial hemorrhage. The patient was a 24-year-old male, who had been followed for over 3 years and 9 months, and received two operations because of bilateral extension of the tumor. During follow-up he had experienced frequent euphoric spells untill mental deterioration became evident. Then he went suddenly into deep coma and intracranial hemorrhage was found with CT scan. Hemorrhage was probably attributed to the marked stretching of cerebral arteries around tumor, although autopsy could not confirm the source of hemorrhage. Neurological characteristics of a giant osteochondroma arising from the skull basis were described in comparison with over skull basis tumor such as chordoma, and special reference was made for CT scan diagnosis.

Adult↗
PubMed1982

[A case of cavernous hemangioma with acute visual disturbance (author's transl)].

The authors report a case of parasellar cavernous hemangioma having grown to the suprasellar region within 3 year's period and showing acute visual disturbance caused by intratumoral hemorrhage. A 44-year-old woman, who had experienced spontaneous intracerebral hematoma in the left inferior frontal lobe 3 years ago and then obtained good recovery in the post-operative period had suddenly developed decreased visual acuity of the left eye without other neurological deficit. CT scan revealed an irregular mass lesion in the chiasmal region, which had a crown-like high density area over the suprasellar low density. Carotid angiogram showed a suprasellar avascular mass and the left A1 segment showed marked narrowing. Neither tumor nor venous pooling was visible in the capillary and venous phase. Surgery disclosed a reddish dark tumor with thin capsular wall, extending from the left cavernous sinus to the suprasellar region, and it was accompanied by intratumoral hemorrhage compressing the left optic nerve. The tumor was subtotally removed. High density area on the precontrast scan was confirmed to be intratumoral hemorrhage and the low density area was of organized tissue due to thrombosis. Histological finding was compatible to cavernous hemangioma. Postoperatively visual acuity of the patient was well recovered, but left 3rd and 6th cranial nerve palsy followed. The authors discussed the mechanism of acute onset and CT findings of the cavernous hemangioma arising in the chiasmal region with a review of literature.

Adult↗
PubMed1982

[Pharmacokinetic one-compartment model using neocarzinostain as a prototype drug and its clinical application to chemotherapy for brain tumor. Part II. A clinical trial with selected protocol].

Neocarzinostatin as previously reported, appeared to exhibit an intense cytotoxicity to the glioblastoma cells and some other malignant brain tumor cells, such as pineal germinoma or medulloblastoma, which are notoriously known to disseminate into the cerebrospinal fluid space. In vitro study, the minimum susceptibility of glioblastoma cells to neocarzinostatin was found to be below 0.005 microgram/ml, whereas normal glia cells were not affected at 0.3 microgram/ml. This study indicated that neocarzinostatin was extremely effective in the treatment of malignant brain tumor without affecting normal neural tissue. Pharmacokinetic study was performed in order to establish intermittent intrathecal perfusion therapy and to prevent subarachnoid dissemination of the brain tumor cells. Experimental results were applied to the treatment of 12 patients with brain tumor, who had shown positive cytology of the cerebrospinal fluid. Follow-up investigation showed quite a favorable result and it was considered that prophylactic irradiation to the entire spinal column could be replaced with intrathecal administration of neocarzinostatin. During clinical application no noticeable side effect was encountered and active stimulation of macrophages, which were mobilized into the CSF space, was another unexpected advantage of this treatment.

Adolescent↗
PubMed1982

[Part I. Theory and computer simulation for cerebrospinal infusion].

A pharmacokinetic one-compartment model for the cerebrospinal infusion for the brain tumor chemotherapy is described together with various parameters used for computer simulation. An antitumor protein, neocarzinostatin (NCS) as a prototype drug, has been utilized since it was found effective against glioblastoma cells at extremely low concentration (less than 5 ng/ml) and it is readily inactivated by serum. A very slow infusion velocity was found necessary for an appropriate dose regimen; for example, 0.25mg of the drug should be infused into CSF for about 40 min to attain a drug level of 8 ng/ml.

Antibiotics, Antineoplastic↗
PubMed1982

[Surgery of the hypophyseo-hypothalamic lesions and the circadian rhythm of ADH secretion].

Various clinical disorders of water and electrolytes metabolism were reported in relation to decrease or increase of the plasma anti-diuretic hormone (ADH), however, the estimated ADH value was not infrequently found inconsistent with clinical features. In order to determine the influence from surgical intervention to the hypophyseo-hypothalamic system, continuous estimation of the urinary secretion and specific gravity was performed with computerized analyzer, and it was found that there were at least 5 patterns of postoperative change in rhythmicity of ADH secretion. Most interesting finding was that the ADH was discharged in phasic pattern and irregularly intermingled oligo- and polyuric phases were observed quite in early stage of postoperative observation. Forty cases were examined and this method of examination was found useful in the prognostic view point for the postoperative water and electrolytes disorders.

Adenoma↗
PubMed1981

A pharmacokinetic simulation model for chemotherapy of brain tumor with an antitumor protein antibiotic, neocarzinostatin. Theoretical considerations behind a two-compartment model for continuous infusion via an internal carotid artery.

A pharmacokinetic two-compartment model for the treatment of brain tumors in man was simulated with the aid of a computer. The parameters necessary for the simulations such as inactivation rate constant, elimination rate constant, distribution volume, blood volume, cerebral blood flow, and cytotoxic drug concentration were either determined in this study or obtained from the literature. A proteinaceous antitumor antibiotic, neocarzinostatin (NCS), was utilized as a prototype drug because it has features making it advantageous in the treatment of brain tumor. In particular, NCS has an extremely short half-life in serum (t 1/2 less than or equal to 3 s), while it is relatively stable in the cerebrospinal fluid (CSF) (t 1/2 approximately 50 s). Therefore, the drug level in the cerebral compartment can be made adequately high with an appropriate infusion velocity into the cerebral compartment; however, it was possible to keep the plasma level of the drug much lower than the toxic level. Thus, few side-effects should result. In an in vitro study, NCS was found to exhibit its cytotoxicity to glioblastoma cells at a concentration as low as 0.005 microgram/ml. In contrast, the cytotoxicity was not apparent for the normal glia cells at 0.1 microgram/ml. The model being considered in this investigation is a two-compartment model, which consists of the cerebral compartment and the rest of the circulatory system of the body. In this case the drug is infused via an internal carotid artery. The results of pharmacokinetic simulation and dose regimens for NCs are presented, based on the effective concentration of the drug to glioblastoma cells in culture and the available pharmacological parameters.

Antibiotics, Antineoplastic↗