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Biomedical subjects

Y M Chung

Publications and source records attributed to Y M Chung.

46 records · Page 3Linked to original sources
PubMed1986

Effects of training on human tracking of electrocutaneous signals.

The effects of training on a person's ability to perceive, interpret and utilize information presented via the tactile sense were examined by using a dual-channel electrocutaneous tracking approach. The electrocutaneous code studied was linear pulse rate encoding of information. The stimulus had a pulse width of 200 microseconds and a pulse rate between 2 and 50 pulses per second. Three tracking tasks--visual tracking, one-dimensional electrocutaneous tracking and two-dimensional electrocutaneous tracking--were performed by 20 subjects during eight to nine daily training sessions. The effects of this training regimen were found to be highly significant for both electrocutaneous tracking tasks (p less than 0.00005). The overall average improvement between successive training sessions was 21.6% for one-dimensional electrocutaneous tracking and 22.9% for two-dimensional electrocutaneous tracking. Furthermore, the rate of improvement was fastest during the initial training sessions with a slower rate of improvement seen in most subjects beginning with their fifth session. The cumulative effects of training were also reflected in the lesser amounts of practice and review required by the subjects with each succeeding test session. Results from this study can be used to estimate the amount and rate of improvement that one can expect using a typical training program for tactile sensory aids.

Biomedical Engineering↗
PubMed1986

Behçet's disease in Taiwan--a review of 53 cases.

Clinical manifestations and immunogenetic aspects of Behçet's disease were investigated in the Veterans General Hospital of the National Yang-Ming Medical College, Taiwan. Diagnosis of Behçet's disease was made according to the diagnostic criteria proposed by the Japanese Research Committee of Behçet's disease. Fifty-three patients including 33 men and 20 women have been diagnosed as having Behçet's disease in the past 10 years; 20 cases with the complete type and 33 cases with the incomplete type. About half of these cases were diagnosed in the past 2 years, predominantly by ophthalmologists. Of the 53 cases, ocular lesions were found in 35 cases, 25 men and 10 women. The ages of the onset of the ocular lesions ranged from 10 to 50 years, with the peak distribution between 20-30 years. Bilateral involvement was seen in 24 men and 8 women, and a total of 67 eyes were affected; 37 eyes (55.2%) had the final visual acuity of 0.1 or lower. Immunogenetic study revealed that the incidence of HLA-B51 was significantly higher in the patients than in the normal population.

Adolescent↗
PubMed1986

[Isolation and purification of bovine retina S-antigen].

Fresh bovine retinas were precipitated by ammonium sulfate, and further purified by the Sephadex G-200 column and the hydroxyapatite column. Through the SDS polyacrylamide gel electrophoresis and the isoelectric focusing gel electrophoresis, a single band of protein with molecular weight of 50,000 daltons, isoelectric point at 5.4-5.7, was identified as S-antigen. The yield of S-antigen from crude retina extract was 0.18%, higher than ever been reported. Guinea pigs were injected at the hind footpad with 5-30 micrograms of purified S-antigen which had been emulsified with an equal amount of complete Freund's adjuvant. There are severe uveitis findings in both clinical and pathological examinations. An experimental autoimmune uveitis animal model was successfully established. These results showed that it is an effective and rapid method for purification of retinal S-antigen.

Animals↗
PubMedDate not supplied

Increased expression of peroxiredoxin II confers resistance to cisplatin.

Peroxiredoxin II (Prx II) has been known to be induced by various oxidative stimuli and to play an important protective role from oxidative damage by hydrogen peroxide (H2O2). In this study, we observed that cisplatin as well as H2O2 induced Prx II expression. To examine the correlation between the increased expression of Prx II and chemoresistance, we prepared a Prx II-overexpressing cell line, SNU638 cells, and found it to be more resistant to cell death induced by cisplatin and H2O2 than neo-transfectant cells. We also observed that enhanced expression of Prx II inhibited cisplatin- and H2O2-induced apoptosis, demonstrating that resistance to these cytotoxic agents was due to inhibition of apoptosis. The above results led us to suggest that the overexpressed Prx II protein inhibits cisplatin-induced apoptosis, thereby contributing to chemoresistance of tumor cells, especially to oxidative stress producing anticancer drugs.

Antineoplastic Agents↗