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Biomedical subjects

Y Louagie

Publications and source records attributed to Y Louagie.

43 records · Page 3Linked to original sources
PubMedDate not supplied

[Is the institution of a homograft bank of stripped saphenous veins possible?].

The long-term cryopreservation of viable human venous allografts is discussed. The preservation technique includes immersion in a 15 p. cent Dimethylsulfoxide solution, followed by deep hypothermia in liquid nitrogen at - 196 degrees C. The veins studied were preserved for a period of 1 week to 24 months. Histological and scan electron microscopy examination does not show any specific alteration resulting from the freezing technique. Tissue enzymes assays, titration of the fibrinolytic activity and the rate of prostaglandins synthesis, are not affected by the duration of the preservation period. This cryopreservation technique respects the venous structure and functions; therefore, its clinical use is possible. Strict selection of the stripped veins according to morphological criteria seems therefore absolutely necessary.

Cryopreservation↗
PubMedDate not supplied

Left ventricular aneurysm complicated by congestive heart failure: an analysis of long-term results and risk factors of surgical treatment.

The results of surgical treatment of post-infarction left ventricular aneurysms in 49 patients with congestive heart failure preoperatively were analyzed. Average patient age was 55 years. Preoperative total ejection fraction averaged 30.5 +/- 1.5% (mean +/- SEM), contractile segment ejection fraction was 42.5 +/- 1.1% and end-diastolic volume of aneurysm was 81.4 +/- 10.4 ml. Seventy eight percent of patients underwent coronary artery bypass grafting concomitantly with aneurysmectomy. Mean follow-up after operation was 41.5 +/- 3.5 months. Hospital mortality was 8.2%, the 5 year survival rate was 70 +/- 7% and the 5 year complication free rate was 52 +/- 8%. Mean functional class of dyspnea improved significantly from 2.9 +/- 0.1 preoperatively to 1.6 +/- 0.1 at late follow-up (p less than 0.001). Likewise, isotopic ejection fraction at rest increased from 13.7 +/- 1.3% preoperatively to 30.9 +/- 3.0% postoperatively (p less than 0.0001). Logistic regression analysis isolated two factors which influenced postoperative survival independently: contractile segment ejection fraction (p = 0.045) and myocardial score of left anterior descending coronary artery (p = 0.035). Combining these two risk factors, it was possible to identify a low risk group of patients with a 5 year survival probability of 93 +/- 6%, contrasting with a high risk group of patients having a 5 year survival of 57 +/- 9% (p less than 0.02). Thus, resection of left ventricular aneurysms complicated by congestive heart failure provides improvement in left ventricular function and clinical status.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Early surgery for severe aortic regurgitation.

One hundred and fourteen consecutive patients who underwent aortic valve replacement (AVR) for isolated aortic regurgitation (AR) from 1965 to 1981 are presented. Sixty eight (60%) were preoperatively in NYHA class I-II and 46 (40%) were in NYHA class III-IV. Eighty-two patients had left and right heart catheterization prior to the operation and the severity of regurgitation was assessed angiographically in 93% of those in functional class (FC) I-II. Left ventricular (LV) end-diastolic volume index and end-systolic volume index were elevated even in the mildly symptomatic patients (156.1 and 61.0 ml/m2 respectively). The ratio of LV end-systolic pressure to LV end systolic volume index was diminished in the FC I-II patients. Two patients in FC III died in hospital (operative mortality: 1.7%) and there were 21 late deaths with a 5-year survival of 82.7%. Late survival differed significantly between patients who were preoperatively in FC I and II or III and IV (P less than 0.03). These data suggest that severe AR with altered LV function is an indication for early operation regardless of the presence of absence of symptoms.

Adolescent↗
PubMedDate not supplied

The effect of phenylbutazone on acute hemorrhagic pancreatitis in the rat.

The effect of phenylbutazone on acute experimental pancreatitis was investigated in the rat. Severe necrotico-hemorrhagic pancreatitis was produced by intraductal injection of trypsin. Pretreatment by phenylbutazone did not alter the mortality rate but reduced the severity of pancreatitis as was demonstrated by histological quantification (total score 13.35 +/- 0.80 in treated rats versus 17.67 +/- 0.69 in the control group; P less than 0.01). The protective effect of phenylbutazone seems to be related to the specific anti-inflammatory properties of the drug and not to inhibition of prostaglandin synthesis.

Acute Disease↗
PubMedDate not supplied

[Whipple's operation and tumors of Oddi's sphincter. A series of 17 cases].

Seventeen patients underwent a Whipple operation for carcinoma of the ampulla of Vater. The operative mortality was 11.7% (2/17). Anastomotic dehiscence at the level of the pancreatico-jejunostomy occurred three times and was responsible for one death. The actuarial five years survival rate was 51%. The duodenopancreatectomy remains the operation of choice for ampullary malignancy.

Adult↗
PubMedDate not supplied

Pneumococcal aortic valvar endocarditis with atrio-ventricular perforation.

A case of pneumococcal endocarditis, complicated by a left ventricular-right atrial fistula and a rapidly progressing cardiac failure in a 56 year-old man, is reported here. In the acute period, an aortic valve prosthesis was installed and the atrio-ventricular fistula was closed with patches of pericardium. After serious post-operative complications, the patient left the clinic, cured of his bacterial endocarditis. He unfortunately died two months later of a massive myocardial infarction caused by a previously unrecognized atheromatous stenosis of the anterior descending branch and occlusion of the circumflex vessel. The authors discuss the bacteriological, anatomopathological and clinical aspects of this rare complication of bacterial endocarditis in light of the current available literature.

Aortic Valve↗