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Biomedical subjects

Y Levo

Publications and source records attributed to Y Levo.

At least 181 records · Page 10Linked to original sources
PubMed1974

Increased incidence of urethane induced lung adenomata by autosensitized lymphocytes.

The present work investigates the influence of autosensitized lymphocytes on the carcinogenic response of the host. Urethane treated SWR mice received 6 fortnightly injections of lymphocytes sensitized in vitro against syngeneic fibroblasts. An increased incidence of lung adenomata was found in these mice compared with controls injected with unsensitized lymphoid cells or with lymphoid cells sensitized against unrelated transplantation antigens. Autosensitized lymphocytes also modified the response of host lymphoid cells to concanavalin A or to stimulation in a mixed lymphocyte culture assay. These results indicate that autoimmune lymphocytes may increase susceptibility of a host to the induction of tumours.

Adenoma↗
PubMed1974

Acute disseminated intravascular coagulation as the presenting and predominant clinical manifestation in a patient with a mucinous adenocarcinoma.

A patient with a fulminant clinical course of disseminated intravascular coagulation (DIC) is described. The DIC was first manifested by neurological symptoms and later dominated by hemorrhagic phenomena. Bleeding manifestations were not controlled by treatment with heparin, later supplemented with epsilon-amino-caproic acid and fresh blood. The patient's condition precluded the performance of extensive diagnostic procedures. On the assumption that malignancy was the underlying disease, cyclophosphamide and hydrocortisone were administered. In spite of intensive treatment the patient died. Autopsy revealed mesenteric lymph node metastases of a mucinous adenocarcinoma, probably originating in the colon. It is emphasized that in some patients with malignant disease, acute DIC is the presenting and the predominant symptom. In such patients the hemorrhagic manifestations may not be controlled unless the underlying neoplastic disease is detected and treated.

Adenocarcinoma, Mucinous↗
PubMedDate not supplied

Anaerobic bacteremia: a retrospective four-year analysis in general medicine and cancer patients.

Anaerobic bacteremia was studied in 32 medical patients (mean age 72 years) in a four-year retrospective analysis. Malignancy was the most common underlying disease and probable portal of entry. The gastrointestinal tract was affected most often, followed by the respiratory and urinary tracts. Bacteremia occurred either following invasive (non surgical) procedures or spontaneously. The clinical course ranged from asymptomatic bacteremia, to mild febrile illness, to sepsis and septic shock (two, 12, 16 and two patients, respectively). The case fatality rate was 25%. The causative organisms were Clostridium and Bacteroides species. All organisms isolated were susceptible to chloramphenicol. Early diagnosis and prompt treatment may reduce mortality in cases of anaerobic sepsis.

Adult↗
PubMedDate not supplied

Down's syndrome and autoimmunity.

A patient with Down's syndrome (DS) with multiple autoimmune phenomena is described. She suffered from hypothroidism, a celiac-like enteropathy and hemolytic anemia, and displayed cellular immunity directed against peripheral nerve antigen and basic myeloprotein and serum autoantibodies to many other tissue antigens. Her mother did not suffer from any overt autoimmune disease, but similar autoantibodies were found in her serum. It is suggested that DS resembles other autoimmune diseases, especially that which occurs in the NZB mice. The resemblance is based on the assumption that in both cases genetic and/or viral factors cause T-cell dysfunction which leads on the one hand to increased susceptibility to infections and leukemias, to autoimmune phenomena and to depressed cellular immunity, and on the other hand to increased B--cell reactivity.

Adult↗
PubMedDate not supplied

Laboratory stigmata of connective tissue disorders in asymptomatic carriers of hepatitis B virus.

Sixty-nine asymptomatic HBsAg carriers have been studied for the presence of laboratory stigmata of connective tissue disorders. Anti-nuclear antibodies accompanied by a significant binding of anti-DNA were detected on one carrier only. In contrast, rheumatoid activity was detected in 10 out of 63 carriers, and lymphocytotoxins in 8 out of 33. Carriers had a significantly increased level of circulating immune complexes associated with mild hypocomplementemia. Since none of the carriers had any evidence of liver disease, it is probable that the immunologic abberations were induced by the persistent viral infection rather than liver injury. It seems that some asymptomatic carriers have an occult laboratory-wise, connective tissue disorder which, under yet unknown circumstances, gives rise to an overt immune complex disease.

Adult↗
PubMedDate not supplied

Musculoskeletal manifestations of bacterial endocarditis.

The musculoskeletal (MS) involvement of 91 patients with bacterial endocarditis (BE) is reported. Twenty-three patients (25.2%) exhibited MS symptoms; 74% had arthralgias often associated with arthritis and low back pain (LBP), 48% had myalgias, and 43.4% had LBP. The articular symptoms usually were polyarticular and symmetric, affecting both the large and small joints. Two of 12 patients had a positive test for rheumatoid factor activity, and 2 of 5 had a positive FANA test. Patients with MS symptoms did not differ from those with no such symptoms by their mean age, by their underlying heart disease, or by the nature of their cardiac lesions. They were characterized by female preponderance and increased prevalence of streptococcal infections. In view of our data and the relevant literature, it seems that MS symptoms are common in patients with BE. They often antedate the diagnosis of BE by several weeks and can mimic other rheumatic diseases. Therefore, unexplained rheumatic symptoms should always alert the physician to the possibility of bacterial endocarditis.

Adult↗