[Giant mitochondria. Appreciation under photonic microscope of their incidence in human pathology].
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Biomedical subjects
Publications and source records attributed to Y Lenne.
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Mortality and quality of survival after portacaval anastomosis in cirrhotic patients are such that the validity of the operation was investigated during a retrospective study of 242 cases, operation being for hemorrhage and involving emergency or delayed surgery. Operative mortality was higher in emergency cases, but was improved by stricter selection criteria, particularly of pathological features. Cause of death from secondary factors varied during the two years following anastomosis, with perhaps a high frequency of hepatic failure. Recurrence of hemorrhage was a serious complication often related to hepatic insufficiency, while the onset of combined jaundice-edema-ascites (1 out of 4 patients) was frequently the result of continued alcohol abuse. Portacaval encephalopathy (24,4%) did not worsen the vital prognosis, and was severe in only 3 cases. Alcohol intoxication was very frequent in minor forms. Edema of the lower limbs (34,4% of cases), a frequent complication, appeared to result mainly from hemodynamic causes. A return to work was not possible in 20% of patients, but in only 12% was this due to the anastomosis. Portacaval anastomosis would not, therefore, appear to alter survival of patients from complications of cirrhosis. It suppresses the hemorrhagic risk, however, and the course of the disease is then related only to the cirrhosis and to its stability if abstinence is maintained.
Basing their observations on 11 cases treated personally and 74 cases reported in the published literature, the authors use the histological findings and the course taken by the lesions to separate pancreatic cystadenomas into microcystic adenomas and mucinous cysts. Their classification as a single clinical entity is justified by their almost indentical symptoms : usually of large size and seen mainly in women. A more precise diagnosis requires the use of complementary examinations including ultrasonography, arteriography, and computed tomography. Microcystic adenomas occur throughout the gland and are always benign : mucinous cysts are found mainly in the head or tail regions and may become malignant. Histological examination of the whole lesion is necessary in order to recognize a primary malignant form, and radical excision is required. The risk of changes in any cystic lesion, therefore, implies that controlled excision should be employed rather than simple cystectomy.
The study concerned the macroscopic and microscopic examination of 54 cases of diffuse malignant mesothelioma. Four points were felt to be of interest and worthy of emphasis: --the unilateral nature of the lesions, constant in this series; --the absence of involvement of other serous surfaces; --the tumour-like appearance of the disorder in 2/3 of cases and the appearance of a simple pachy-pleuritis in 1/3; --from a histological standpoint, despite the morphological flexibility of the classically accepted mesothelial cells, the homogenicity of our group, in which tumour morphology was much more epithelial than histiocytic or connective.