Search PubMed⌕ Search

Biomedical subjects

Y Lee

Publications and source records attributed to Y Lee.

At least 505 records · Page 28Linked to original sources
PubMed1984

Role of attempted vaginal delivery in the management of placenta previa.

Sixty-nine documented cases of placenta previa were managed at The Mount Sinai Medical Center during a five-year period. Vaginal delivery was attempted in six instances of partial placenta previa and was successful in five (83%). For these six cases, intrapartum bleeding was not excessive, blood transfusions were not necessary during or after labor, and all Apgar scores were greater than or equal to 7 at one and five minutes. Anemia in a neonate delivered at 32 weeks of gestation was the only neonatal complication that may have been due to intrapartum fetal hemorrhage. This series suggests that routine cesarean section is not necessary for all cases of partial placenta previa. A protocol is proposed for the intrapartum management of suspected placenta previa at term. Further clinical studies are necessary to evaluate the safety and clinical use of this mode of management.

Apgar Score↗
PubMed1983

Peptides, the limbic lobe and schizophrenia.

The human brain contains several peptides with probable synaptic actions, some of which form complex neuronal networks in the limbic lobe (amygdala, hippocampus and temporal cortex). A limbic lobe abnormality has been postulated in schizophrenia on the basis of similarities between schizophrenic symptoms and symptoms in cases of known limbic pathology. Cholecystokinin (CCK), somatostatin (SRIF), neurotensin (NT), vasoactive intestinal polypeptide (VIP) and substance P (SP)-like immunoreactivities were measured by radioimmunoassay in 10 brain areas of 14 schizophrenics and 12 controls. In the schizophrenic group symptoms had been rated in life and the group was divided into Type I (n = 7) and Type II (n = 7) subgroups on the basis of the absence or presence of morbid negative symptoms. In control brains each peptide showed a characteristic distribution with high levels in cortex (CCK), limbic lobe (SOM, NT, VIP) or striatal areas (SP) and low levels of each of the peptides in thalamus. Significant (P less than 0.05) differences between groups were: reductions of CCK and SOM in hippocampus and CCK in amygdala in Type II schizophrenics, and CCK in the temporal cortex of the total schizophrenic group; and elevations of VIP in amygdala in Type I schizophrenics and of SP in the hippocampus in the total schizophrenic group. The findings could not be explained by variables such as age, delay between death and necropsy or to neuroleptic medication. These clinical-state related alterations in the peptide content of the limbic system in schizophrenia may illuminate the pathophysiological basis of the disease, particularly the distinction between Type I and II syndromes.

Brain↗
PubMed1983

Effects of Age, Water Stress, and 1-Aminocyclopropane-1-carboxylic Acid on Leaflet Movement in Albizzia julibrissin.

The movement patterns of Albizzia julibrissin leaflets transferred from light to darkness differ for leaflets of different age: the older the leaflet, the slower and less completely it closes. Water stress, which enhances ethylene synthesis in other plants, and 1-aminocyclopropane-1-carboxylic acid (ACC), precursor of ethylene, both mimic the effect of aging by reducing the rate and extent of dark-induced closure. Brief far-red compared to red irradiation before darkness does not appear to alter the closure of young leaflets, but far-red preirradiation retards the closure of middle-aged and old leaflets floating on water, and middle-aged leaflets treated with ACC. A change in some membrane property and/or cell wall lignification are suggested as possible explanations for the alteration of leaflet movement.

Journal Article↗
PubMed1982

A follow-up study of plasma beta-N-acetylglucosaminidase activity and diabetic retinopathy--observed for 2 years.

The correlation of Plasma beta-N-acetylglucosaminidase (NAG) activity and the development of diabetic retinopathy was observed in 117 diabetic patients (male 52, female 65) who had been observed for 2 years. The plasma NAG activity was measured at least 3 times per year (6 approximately 9 times altogether). The eye-ground findings at the beginning of the study and 2 years later were studied according to Scott's classification. Forty-four percent (19 cases) of the 43 patients with higher NAG activity (greater than 525 nmole/h/ml) and 27% (20 cases) of the 74 patients with lower NAG activity (less than or equal to 525 mole/h/ml) showed a worsening of the eye findings (p greater than 0.05). The frequencies of patients showing a worsening of the eye findings in patients with higher fasting blood glucose (FBG) values (greater than or equal to 140 mg/dl) and in patients with lower FBG values (less than 140 mg/dl) were 45% (17 in 38 cases) and 28% (22 in 79 cases), respectively (p greater than 0.1). When the NAG activity and the FBG value were considered together, there were 16 patients with both higher FBG values or higher NAG activity, and 52 patients with both lower FBG values and lower NAG activity. The frequencies of the patients who had a worsening of the eye findings were 56% (9 cases), 37% (18 cases), and 23% (12 cases), respectively. The difference was significant (p less than 0.05). In the present study, the plasma NAG activity showed no relation to diabetic retinopathy, but the results suggest that the plasma enzyme estimation may add further information to the FBG value and so help in predicting the development of diabetic retinopathy.

Acetylglucosaminidase↗
PubMed1982

[Echocardiographic manifestations of the heart in the Hunter syndrome: report of a case].

Cardiac involvement of mucopolysaccharidosis has not been well characterized by echocardiography. In this paper, we reported a case of Hunter syndrome with special reference to the noninvasive diagnosis of cardiac anomalies. A 21-year-old male of Hunter syndrome was referred to our noninvasive laboratory for the evaluation of his heart murmurs. He was strikingly dwarfed, 115 cm in height and 28 kg in weight, and had apparently Gargoyle-like facial appearance. Physical examination disclosed a mild funnel chest and a loud systolic murmur. Blood pressure was 98/56 mmHg and regular pulse rate was 100/min. The chest X-ray film revealed a shift of the heart to the left with a prominent pulmonary artery segment. There were no signs of pulmonary congestion. The electrocardiogram demonstrated right axis deviation, clockwise rotation and left atrial overload. In phonocardiograms, a basal ejection and an apical scratchy systolic murmurs were recorded. The latter was associated with a presystolic murmur and a loud first heart sound. A loud pulmonary second heart sound was also present. Outstanding findings were observed in the two-dimensional and M-mode echocardiograms, which showed remarkable thickening of both mitral valve leaflets with reduced opening. There was also generalized thickening of tricuspid and aortic valves, and endocardium of the free ventricular wall. Two leaflets of the tricuspid valve were visualized to prolapse, but the aortic valve motion appeared intact. In addition, echocardiograms revealed the dilatation of right-sided cardiac chambers and pulmonary artery, but the size of the left ventricle was rather small. Pulsed Doppler echocardiography demonstrated systolic turbulence in the right atrium in the vicinity of the tricuspid valve orifice. Stenotic turbulence was also recorded in the inflow tract of the left ventricle during diastole. Thus, the final diagnosis of predominant mitral stenosis associated with tricuspid valve prolapse and pulmonary hypertension was obtained. In conclusion, cardiac involvements in Hunter syndrome were precisely evaluated by noninvasive methods. Hunter syndrome may be considered as one of the etiologies producing mitral stenosis.

Adult↗
PubMed1981

Identification of a lysine residue at a nucleotide binding site in the firefly luciferase with p-fluorosulfonyl[14C]benzoyl-5'-adenosine.

Firefly luciferase is 80-90% inactivated within 3 h upon incubation with the adenine nucleotide analogue p-fluorosulfonylbenzoyl-5'-adenosine (FSBA). Although 4 mol of 14C-FSBA/mol of enzyme is irreversibly bound during inactivation, only 1 mol of 14C-FSBA appears to be specifically directed to an adenine nucleotide binding site on the enzyme. The other 3 mol of 14C-FSBA is bound to the protein nonspecifically. The major radioactive peptide in a tryptic digest os labeled luciferase was isolated and shown to have the following amino acid sequence: *Lys-Gly-Glx-Asx-Ser-Lys, where *Lys is the radioactive derivative of the lysine residue that was sulfonylated during the inactivation.

Adenosine↗
PubMed1981

Reduced levels of plasma 1,5-anhydroglucitol in diabetic patients.

Anhydroglucitol in human plasma was studied by high pressure liquid chromatography, which was employed to simplify sampling procedures for the polyol assay and to avoid enzymatic treatment of the plasma for removal of glucose. Polyols in the column effluent were assayed by a flow fluorometric method, which involved two continuous successive reactions; periodate oxidation and the Hantzsch reaction. Plasma, 1 ml each, from 55 diabetic and 18 control subjects was deproteinized, concentrated, and subjected to the liquid chromatography. The results of this analysis indicated that the plasma anhydroglucitol level showed an inverse correlation with the plasma glucose level, while the correlation of glycerol and glucose levels was obscure.

Blood Glucose↗
PubMed1981

Effects of phototherapy on serum unbound bilirubin i icteric newborn infants.

Sera from 39 preterm and 35 full-term infants with hyperbilirubinemia, undergoing phototherapy continuously for 48 h, were assayed for unbound bilirubin by the peroxidase oxidation method. Assessment was done to determine the influence of therapeutic exposure to light on the serum unbound bilirubin concentrations in preterm and full-term infants. At 24 and 48 h after initiation of phototherapy, the unbound/total bilirubin ratios, as well, as the serum total and unbound bilirubin levels showed statistically significant declines of values in both preterm and full-term infants. It is concluded that, following phototherapy, the serum levels of unbound bilirubin decline more conspicuously than the decrease in serum total bilirubin levels.

Bilirubin↗