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Biomedical subjects

Y Le Fichoux

Publications and source records attributed to Y Le Fichoux.

At least 73 records · Page 4Linked to original sources
PubMed1992

[Congenital toxoplasmosis in the Alpes-Maritimes region. Apropos of 26 cases observed between 1984 and 1990].

Twenty-six cases of congenital toxoplasmosis observed in the department of Alpes Maritimes (Chief Town: Nice) between 1984 and 1990 are reported. All affected children were treated by pyrimethamine and sulfonamide as soon as the diagnosis was established. None of them exhibited serious sequellae. In most cases (58%) there were no clinical manifestations in agreement with other reports. Benign manifestations were observed in 10 cases (38%): 4 chorioretinitis; 4 intracranial calcifications: 1 febrile seizure; 7 hyperproteinorachias: 3 isolated and 4 associated with other signs. In 3 cases, secondary lesions appeared during the treatment period. This confirms the need for active therapeutic research in order to decrease the risk of late ocular complication which is the major problem of the disease.

Child↗
PubMed1992

[Fungal myocarditis in acquired immunodeficiency syndrome].

The authors report 8 cases of fungal myocarditis discovered at autopsy of a series of 118 patients with AIDS. The cardiac disease was symptomatic and responsible for death in 2 cases. Antemortem diagnosis of fungal infection was made on examination of bronchioloalveolar lavage, the cerebrospinal fluid or gastrointestinal biopsy. The demonstration of intramyocardial pathogens was postmortem in all cases. The organism was Candida albicans in 3 cases, Cryptococcus neoformans in 3 cases, and Aspergillus fumigatus in 2 cases. The lesions were not confined to the heart; multi-visceral fungal involvement was diagnosed at autopsy in all cases. Cryptococcal and Candida myocarditis have already been described in most autopsy series in AIDS, but Aspergillus myocarditis is very rare. These fungal myocarditis are usually clinically latent or masked by neurological or respiratory symptoms.

Acquired Immunodeficiency Syndrome↗
PubMed1990

[Acanthamoeba keratitis in subjects with contact lenses].

A new case of Acanthamoeba keratitis in a young woman using contact lenses is reported. Although the patient strictly complied with decontamination rules, she developed a huge corneal abscess invading the anterior chamber. After a misleading initial phase, the diagnosis was suspected on clinical grounds and was confirmed by parasitologists. The infection followed a favourable course, thereby avoiding surgery and its unpredictable consequences, but an opaque speck remained in the centre of the cornea. This case illustrates a pathology which is getting less and less exceptional, even in France where such pathogens can be found in the water for normal household use. Subjects wearing contact lenses and who are particularly exposed should be warned of the risk of infection they incur. Doctors should be taught to bear this diagnosis in mind in order to guide parasitological investigations and to obtain confirmation as early as possible.

Acanthamoeba↗
PubMed1986

[Spinal hydatidosis. Failure of albendazole].

A recession of eighteen months is not enough to evaluate efficacy of albendazole therapy on spine hydatic cyst in spite of a negative specific serology by HAI and electrophoresis. Specific IgE and precipitates system number 5 seem not good tests for the following of evolution. Inoculation of mouse with bone biopsy is an interesting test to evaluate the viability of the cyst.

Albendazole↗