Biomedical subjects
Publications and source records attributed to Y L Liu.
This paper presents clinical observations on the preventive effect of cimetidine for stress ulcer bleeding in severe burns. It shows that gastrointestinal bleeding after severe burn is significantly reduced, and the incidence of acute gastro-duodenal ulcer lowered by administration of cimetidine.
Stress ulcers are one of the complications of severe burns. As there is often profuse bleeding into the alimentary tract, its early diagnosis and prompt treatment are of the utmost importance. From 1958 to 1980 we encountered 91 cases of postburn stress ulcers among whom 12 were treated operatively because of severe haemorrhage.
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Female rats were fed purified rations containing 20% fat during gestation and lactation. The fat content was butter oil, an equal mixture of butter oil and lard, or safflower oil. Each litter size was reduced (at random) to 2 male and 2 female pups 1 day postpartum, and these offspring were feed a commercial ration after weaning and until they were 20 weeks of age. When dams were fed safflower oil, fewer of them produced litters after mating, and their behavior during lactation was less than optimal. Litter size and birth weights were similar in all dams producing litters. The type of fat fed to the dam in the perinatal period did not influence the growth, development, and spontaneous activity of the offspring. However, the offspring from the dams fed safflower oil exhibited poorer learning performance in a T-maze and sometimes had a longer time of inactivity following auditory stimulation than did the offspring from dams fed the other types of fats.
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A chimeric vector was constructed to express cucumber mosaic virus (CMV) satellite (Sat) RNA and coat protein (CP). Transgenic lines of tobacco cultivar G-140 expressing CP and Sat-RNA were obtained; these lines had high resistance to CMV. Fifty to 70% of the transgenic plants were symptomless 90 days after inoculation with 25-50 micrograms/ml of CMV. Resistance was about twice that conferred by the Sat-RNA or the CP gene alone in transformed plants.