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Biomedical subjects

Y Kosugi

Publications and source records attributed to Y Kosugi.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Value of exercise echocardiography in evaluating left ventricular systolic function in mitral stenosis].

Exercise echocardiography was performed for 34 patients with mitral stenosis (MS) to evaluate left ventricular (LV) systolic function. The patients were categorized in three groups according to the work loads attained: Group I, 14 patients who attained 25 watts; Group II, 10 patients, 50 watts; and Group III, 10 patients, 75 watts. Among these groups, there were no statistical differences between the resting echocardiographic LV systolic function and their cardiac catheterization data. Resting LV end-diastolic and end-systolic dimensions (EDD and ESD) did not differ by group. During exercise, EDD and ESD decreased significantly in all groups, but ESD at the maximum exercise in Group I was greater than those of the other groups. The percent fractional shortening of the left ventricle (%FS) decreased significantly with exercise in Group I, while it increased significantly in the other groups. The mean velocity of circumferential fiber shortening (mean Vcf) increased significantly in all groups, but the extent was least in Group I. The exercise-induced changes in %FS (delta %FS) and mean Vcf (delta mean Vcf) correlated closely with exercise duration (r = 0.80, r = 0.73), but this was not the case in the mitral valve area. Postoperatively, exercise echocardiography was also performed for 14 patients with mitral stenosis; two of seven patients in Group I, four of five in Group II, and two in Group III showed significant improvement in exercise tolerance after surgery. However, the other six patients showed no change in their exercise tolerance. The former patients had positive values in delta %FS and more than 0.5 circ/sec in delta mean Vcf during pre-operative evaluations, while except one patient, those who did not improve had negative delta %FS values and less than 0.5 circ/sec in delta mean Vcf. It was concluded that the change in LV systolic function during exercise echocardiography reflects LV functional reserve in patients with MS, and provides valuable information for evaluating the severity of, indications for and benefits from surgery for MS.

Blood Pressure↗
PubMed1987

Cell cycle perturbation of cultured C6 glioma cells following short-term contact with a low dose of ACNU.

The purpose of this study was to investigate the cell cycle perturbation of cultured C6 rat glioma cells induced by 1-(4-amino-2-methyl-5-pyrimidyl)methyl-3-(2-chloroethyl)3-nitrosourea hydrochloride (ACNU) using simultaneous flow cytometric measurements of DNA and bromodeoxyuridine (BrdU) content. A new graphic computer program permitted the quantification of cell density in hexagonal subareas and allowed the fraction of BrdU-labeled cells with mid-S phase DNA content (FLS) to be defined in a narrow window. The cell kinetic parameters such as cell cycle time (Tc) and S phase time (Ts) were estimated from a manually plotted FLS curve at 18 and 6 hr, respectively. The major effect of ACNU on the cell cycle was an accumulation of the cells in the G2M phase 12 to 24 hr posttreatment when compared to G2M traverse of untreated cells. For the two-dimensional analysis, cells were labeled with BrdU and then treated with ACNU, or treated with ACNU and then labeled with BrdU. It was concluded that the cells in the S and G2M phases at the time of ACNU administration progressed to mitosis but that the G1 phase cells accumulated in the subsequent G2M phase. Two-dimensional FCM analysis using BrdU provided a useful tool in studying cell cycle perturbation.

Animals↗
PubMed1986

[Left ventricular systolic performance during exercise in patients with hypertrophic cardiomyopathy].

The clinical profiles in patients with hypertrophic cardiomyopathy who had exercise-induced deterioration in systolic performance of the left ventricle (LV) were investigated using exercise echocardiography. The materials consisted of 32 patients, which who categorized in two groups according to the extent of % shortening fraction of the LV (% SF) at the peak exercise; 21 whose % SF was increased (group I: from 40.9 +/- 7.2% at rest to 44.2 +/- 8.0% at the peak exercise) and 11 whose % SF was decreased (group II: from 40.8 +/- 7.3% to 34.8 +/- 6.9%). There were no significant differences between these two groups as to the resting echocardiographic data or the prevalence of pressure gradient in the LV outflow tract. The frequency of symptoms, such as chest pain and exertional dyspnea, was higher in the group II (73%) than in the group I (38%). The time of exercise tolerance was significantly shorter in group II than in group I (I: 9.2 +/- 1.9 min., II: 7.4 +/- 2.6 min., p less than 0.05). Five patients (45%) in group II and four (19%) in group I developed at least 2 mm ST segment depression during exercise electrocardiography. Twenty-four hour ambulatory ECG monitoring showed a high prevalence of ventricular arrhythmias in group II. Seven (78%) of nine patients in group II and five (28%) of 18 in group I had abnormal 201T1 myocardial scintigrams. Left ventricular ejection fraction was not significantly different between the two groups, but the end-diastolic pressure was higher in group II (19 +/- 6 mmHg) than in group I (15 +/- 4 mmHg). All patients who underwent coronary arteriography had no significant stenosis. Thus, there are significant differences in the clinical features between the two groups of patients who had reciprocal LV responses during exercise. These findings should be considered in the management of patients with hypertrophic cardiomyopathy.

Adult↗
PubMed1980

[Auditory electroencephalography (author's transl)].

New monitoring method of EEG using auditory expression were proposed; (1) Multification method, (2) Frequency modulation method and (3) Harmonic musical scale method. The first has merit surveying the trend of EEG, the second detecting paroxysm and the third detecting abnormal basic activities.

Biofeedback, Psychology↗