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Biomedical subjects

Y Konttinen

Publications and source records attributed to Y Konttinen.

31 records · Page 2Linked to original sources
PubMed1987

[Chronic cephalalgia as a sequela of rheumatic spondylarthritis of the cervical spine].

Deformity and instability of the cervical spine is quite frequently recordable from patients with chronic rheumatoid arthritis. More than 70 per cent of patients who had been suffering this rheumatoid disease for more than ten years with mutilating peripheral joint lesions exhibited radiologically visible and clinically recordable cervical spine disorders. Anterior atlanto-axial subluxation has proved to be the most common rheumatic deformity of the cervical spine and was found to cause severe, even intolerable occipito-cervical headache. The authors have obtained good results from posterior C1-C2 fusion operation on patients in whom headache had been invalidising and resistant to conservative treatment.

Arthritis, Rheumatoid↗
PubMed1986

Dysphagia and micrognathia in a patient with juvenile rheumatoid arthritis.

This report describes the case of a 35-year-old man with juvenile rheumatoid arthritis. The patient experienced swallowing difficulties that were initially thought to be a result of the disease affecting the cervical spine. A maxillofacial examination, however, showed a total loss of the mandibular condyles, short rami and bodies, and a retrusion of the jaw. This was considered to be the main cause of the dysphagia, and not a glossopharyngeal nerve compression. The surgical-orthodontic management of these difficult cases is discussed.

Adult↗
PubMed1985

Lymphocyte activation in rheumatoid arthritis synovial fluid in vivo.

Monoclonal antibodies were used in avidin-biotin-peroxidase complex staining for activation marker analysis of rheumatoid synovial fluid cells. Although Ia expression indicates T cell activation, cells displaying receptors for interleukin 2 (Tac)-and transferrin receptor (T9)- positive proliferating cells were relatively few. Similarly, activated terminal effector cells of suppressor/cytotoxic nature were scarce in rheumatoid synovial fluid, as suggested by a low expression of Tac and 4F2 markers. The in vivo situation in the rheumatoid arthritic (RA) joint does not seem to be due to the inability of synovial fluid lymphocytes to become activated, because mitogen stimulation in vitro, in spite of a low proliferative response, induced expression of all the activation markers studied. The relevance of the present observations to the down-regulation of the active, inflammatory-immune response in situ is speculative, but the data show that in spite of T-cell activation and Ia expression, activated terminal effector cells of suppressor/cytotoxic nature are few in the RA joint in vivo.

Antibodies, Monoclonal↗
PubMed1983

T and B lymphocytes, macrophages and Langerhans' cells during the course of contact allergic and irritant skin reactions in man.

The in situ distribution of lymphocyte subclasses, macrophages and Langerhans' cells was analysed with histochemical (ANAE staining), immunohistochemical (immunoperoxidase) and electron microscopic methods during the course of epicutaneous allergic and irritant skin reactions. Serial biopsies were taken during the first 5-72 hours following the allergen (nickel and chromium) or irritant (non-anoic acid and dithranol) application. Empty and petrolatum-filled Finn chambers were used as controls. No significant differences in the number of mononuclear inflammatory cells or their subclasses were found in the early recognition and elicitation phases of the allergic or irritant-induced reactions. Nor was there any difference in the frequency of lymphocyte-Langerhans' cell contacts, although exocytic cells were most frequent in dithranol reactions.

B-Lymphocytes↗
PubMedDate not supplied

Cartilage oligomeric matrix protein (COMP) is modified by intra-articular liposomal clodronate in an experimental model of arthritis.

OBJECTIVE: High-dose liposomal bisphosphonates exert apoptotic effects. This work studies the chondroprotective and anti-inflammatory properties of intra-articularly administered low-dose, non-cytotoxic liposomal clodronate. METHODS: Antigen induced arthritis in rabbits was treated with intra-articular injections of liposomal clodronate. Drug effects on cartilage oligomeric matrix protein COMP was assessed using immunohistochemistry and morphometry of synovial membrane and hyaline articular cartilage. RESULTS: COMP remained close to normal in liposomal clodronate treated superficial articular cartilage compared to a significant loss of COMP in arthritis controls treated with empty liposomes. The middle and deep layers of the hyaline articular cartilage were characterized by highly increased COMP expression in liposomal clodronate treated AIA joints compared to controls. In contrast to cartilage, synovial COMP expression was slightly decreased as a result of liposomal clodronate treatment. CONCLUSION: Low-dose, non-cytotoxic liposomal clodronate exerts a dichotomous effect on synovial membrane and articular cartilage COMP in the AIA model. COMP is a useful inflammation marker in the synovial tissue, but it also contributes to the structural integrity of the hyaline articular cartilage forming bridges between type II and IX collagens. Enhancement of COMP in clodronate treated AIA cartilage suggests a chondroprotective and anti-inflammatory effect in the inflammatorily damaged and mechanically strained cartilage.

Animals↗
PubMedDate not supplied

Sjögren's syndrome: terminology.

In spite of our continuously improved pathobiological understanding, there is still no consensus on terminology and disease criteria in Sjögren's syndrome (SS). This survey points out discrepencies in the current description of the syndrome, and argues for a new classification model. We suggest that the present nomenclatures for the global disease (Sjögren's disease) and disease subsets (primary and secondary SS) be retained until additional pathobiological insights give rise to new and descriptive terms. We do find evidence, however, to support a new terminology and classification of the main immunoinflammatory manifestations of primary SS. Accordingly, three "exocrine" and four "non-exocrine" subgroups of disease manifestations are here defined. The usefulness of the proposed model should be evaluated in clinical studies and in a debate engaging all of the medical specialities involved.

Autoimmune Diseases↗