Search PubMed⌕ Search

Biomedical subjects

Y Katayama

Publications and source records attributed to Y Katayama.

At least 775 records · Page 43Linked to original sources
PubMed1984

[Prostatic tissue and fluid levels of DL-8280].

The concentration of DL-8280, a new pyridone carboxylic acid, in the prostatic tissue and fluid after oral administration to man was studied. The drug was concentrated in the prostate and the concentration was dose-dependent. The ratios of prostatic tissue and fluid levels to serum levels were 1.62-1.79 and 1.65-1.96. respectively.

Administration, Oral↗
PubMed1983

Anti-tumor activity of endotoxin depends on activation of serum complement fragments.

The anti-tumor activity of endotoxin (LPS), derived from E. coli O127, on the subcutaneous tumor MH134 inoculated into C3H/He mice in vivo was examined. On repeated examination, LPS administration of 50-100 micrograms/head induced a 50% complete cure rate. However, pretreatment with K76COONa inhibited the anti-tumor activity of LPS, and no case of cure could be found. These results showed that the main anti-tumor activity of LPS administration consisted of complementary activation, mainly from the C5 step. The fact that the intraperitoneal administration of human complement activated serum with agar apparently inhibited the tumor growth in vivo certified these phenomena.

Animals↗
PubMed1983

Changes with aging in serum lipoproteins and apolipoprotein C subclasses.

The effects of aging on serum lipids, lipoproteins and apolipoprotein C subclasses in very low density lipoprotein (VLDL) were investigated in healthy male subjects aged from the 1st to the 9th decade. The serum cholesterol, phospholipid and triglyceride concentrations, the serum beta-lipoprotein concentration determined immunologically, and the beta-lipoprotein percentage determined by electrophoresis showed the lowest levels in the 2nd decade, increased gradually with age, attained the highest level in the 6th to 7th decade and slightly declined in the 9th decade. The VLDL-low density lipoprotein (LDL) cholesterol level changed almost in parallel with the serum total cholesterol level, but the HDL cholesterol level and the apolipoprotein A concentration remained almost constant showing no age-related change. The free cholesterol percentages in every lipoprotein fraction and the apolipoprotein content in LDL were higher in the subjects in the 6th and 7th decade than those in the 2nd to 3rd decade. The apo C II/C III ratio in VLDL increased with age. These data suggest that the ability to active lipoprotein lipase may not be impaired but the lecithin:cholesterol acyltransferase (LCAT) activity declines with age.

Adolescent↗
PubMed1982

On the occurrence and physiological effect of somatostatin in the ciliary ganglion of cats.

Somatostatin-like immunoreactive nerve fibers occurred among and around ganglion cells in the form of punctate structures or varicose processes in the cat ciliary ganglion. The density of the fibers varied greatly from region to region and approximately 25% of the whole population of neuronal soma that appeared in a single section were surrounded by immunoreactive fibers. No somatostatin-positive cell bodies were observed. Application of somatostatin to this ganglion in vitro by superfusion induced membrane hyperpolarization in approximately 60% of the neurons examined. The hyperpolarization was preserved in a low Ca/high Mg medium. This response was associated with a decrease in input membrane resistance and was reversed in polarity at nearly --90 mV. The present findings suggest that somatostatin may play a role as a neurotransmitter or modulator in this parasympathetic ganglion.

Animals↗
PubMed1982

Voltage-clamp analysis of peptidergic slow depolarizations in bullfrog sympathetic ganglion cells.

1. The membrane currents during the late slow excitatory post-synaptic potential (late slow e.p.s.c.s) and luteinizing hormone-releasing hormone (LHRH)-induced depolarization of nicotinized and atropinized bullfrog lumbar sympathetic ganglion cells were studied with voltage-clamp methods. 2. Two types of late slow e.p.s.c. were observed. The Type I response was associated with a decreased conductance and was depressed by membrane hyperpolarization. The Type II response was accompanied by an increased conductance and was augmented by membrane hyperpolarization. 3. LHRH also induced two types of responses. The nature of the LHRH-induced current and the late slow e.p.s.c. in each neurone was similar, if not identical. 4. The Type I response appeared to be produced primarily by a suppression of the M current (Brown & Adams, 1980) and partially by a depression of the resting K+ conductance. The Type II response is probably due to an increased conductance to Na+ or Na+ and some other cations.

Action Potentials↗
PubMed1982

[Antibacterial activities of cefotiam against various pathogens isolated from clinical materials (author's transl)].

Bacteriological evaluation was made on cefotiam (CTM), a new broad-spectrum cephalosporin antibiotic, and the following results wer obtained. 1) CTM has shown very potent antibacterial activities against Staphylococcus aureus, Escherichia coli, Edwardsiella tarda, Citrobacter intermedius, Salmonella, Klebsiella, Proteus mirabilis, Proteus rettgeri, Proteus inconstans, Yersinia enterocolitica, Aeromonas hydrophila, Plesiomonas shigelloides and Pseudomonas putrefaciens. 2) Streptococcus faecalis, Enterobacter and Proteus morganii isolated from urine, Serratia and glucose non fermentative Gram-negative bacilli except Pseudomonas putrefaciens, were almost insusceptible to cefotiam.

Bacteria↗