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Biomedical subjects

Y Katayama

Publications and source records attributed to Y Katayama.

At least 613 records · Page 34Linked to original sources
PubMed1990

[Urodynamic study of the upper urinary tract in the state of ureteral stenting--diuresis renography].

On 24 reno-ureteral units of 21 patients with a silicon ureteral stent, urodynamic study of the upper urinary tract was performed by diuresis radionuclide urography (DRU). We obtained the following conclusions. 1. A silicon stent was useful to maintain urinary stream in ureteral operation. 2. In extrinsic ureteral stricture due to pelvic malignant tumor, pattern of DRU was still poor after indwelling stent. 3. When a stent of the 5-8F's outer diameter was used for an adult, a too thick stent for the ureteral size might rather interrupt the urinary stream. 4. Patterns of DRU and GFR measured by Gates' method in the state of ureteral stenting could warns that hydronephrotic kidney may develop.

Furosemide↗
PubMed1990

[Study on urinary low molecular protein and enzyme in primary vesico-ureteral reflux patients].

Urinary beta-2-microglobulin (beta 2-MG), urinary N-acetyl-beta-D-glucosaminidase (NAG), urinary creatinine (Cr) and serum creatinine level were measured in 79 patients with primary vesico-ureteral reflux. Comparing the data between conservatively treated group and operated group, between pre and post operation, we obtained the following conclusions: 1. From urinary beta 2-MG and NAG, renal tubular damage tended to increase in both conservatively treated group and operated group in proportion to the grade of reflux. But the degree of tubular damage was more severe in the conservatively treated group than in the operated group. 2. Tubular reabsorption ability was lower in the operated group than in the conservatively treated group. 3. In patients with severe tubular damage, improvement of tubular function was seen at the early stage after operation. 4. Anti-reflux operation was shown to be effective even in improving glomerular function.

Acetylglucosaminidase↗
PubMed1990

[Localizing methods of primary hyperparathyroidism and those results].

The results of several pre-operative localizing methods and pathological findings were compared in 11 patients with primary hyperparathyroidism. 1. The accuracy rate was highest with selective blood sampling from the thyroid vein and MRI, which was 75% with both methods. The 3rd was dual photon scintigraphy, the accuracy rate being 62.5%. The 4th was ultrasonography, 57.1%, and the rate was lowest with CT, 25%. 2. MRI-a new localizing method-has a weak point that it cannot differentiate lymph nodes from parathyroid adenoma/hyperplasia. 3. Not to overlook small lesion of primary hyperplasia, several localizing methods should be performed before initial neck exploration.

Adult↗
PubMed1990

[Calcium urolithiasis and bone change].

Bone mineral contents of calcium urolithiasis patients (105 males and 52 females) were measured by the microdensitometry (MD) method, and the patients were divided into the MD normal group and the MD abnormal group. The patients were also divided into the group (21 males and 3 females) treated with thiazides for 1 year or more and the nontreated group to examine various factors in blood and urine. [Nontreated group] The rate of MD abnormality was higher in younger males. The rate tended to increase with age in females. Alkaline phosphatase values were significantly higher in MD abnormal group males than in MD normal group males. Urinary calcium excretion and PTH values were significantly higher in MD abnormal group females than in MD normal group females. Comparison of hypercalciuria and normocalciuria revealed no significant difference between the MD normal rate and the MD abnormal rate. Comparison of single of stone formers and recurrent stone formers also revealed no significant difference between the MD normal rate and the MD abnormal rate. [Treated group] PTH and alkaline phosphatase values were significantly higher in the treated group than in the nontreated group. Alkaline phosphatase values were significantly higher in the MD abnormal group. From the viewpoint of stone recurrence prevention, the monitoring of bones where the majority of calcium in the body is present is considered important besides behavior of calcium in blood and urine.

Absorptiometry, Photon↗
PubMed1990

Role of arachidonic acid metabolism on ischemic brain edema and metabolism.

Arachidonic acid is liberated from damaged cell membranes during ischemia and is the source of vasoactive prostanoids. In this study, specific drugs that influence AA metabolism were investigated for their effects on brain edema and energy metabolites during ischemia. The agents tested were: methylprednisolone (phospholipase A2 inhibition), indomethacin (cyclooxygenase inhibitor), trapidil (TXA2 synthetase inhibitor), and OP-41483 (prostacyclin derivative). Cerebral ischemia was produced using bilateral common carotid artery occlusion in spontaneously hypertensive rats. Brain water content and concentrations of ATP, pyruvate, and lactate were determined 3 hr after occlusion. Compared with its vehicle, methylprednisolone significantly reduced water content and lactate concentration and maintained high levels of ATP. Indomethacin had no effect on brain water content nor metabolite levels. Trapidil decreased water content and lactate levels and increased levels of ATP and pyruvate. OP-41483 had no effect on water content and lactate, but maintained ATP and pyruvate at high levels. These results indicate that some of the AA metabolites may play an important role in the development of brain edema and in the impairment of energy metabolism.

Animals↗
PubMed1990

Effects of fluosol-DA on brain edema, energy metabolites, and tissue oxygen content in acute cerebral ischemia.

Perfluorochemicals were developed as a blood substitute and were reported to have an advantage in oxygen transport compared with blood. The present study was undertaken to investigate the therapeutic effects of a perfluorochemical, FDA, on brain edema and metabolites in acute cerebral ischemia. Cerebral ischemia was induced in SHR by BLCO followed by recirculation. The FDA administration resulted in (a) the significant inhibition of brain edema as shown by brain water content in the treated group, and (b) significant amelioration of metabolic impairments as shown by lesser degree of ATP and pyruvate decrease and lactate accumulation. The TpO2 was compared between FDA-infused and nontreated group during ischemia. The FDA-infused group had significantly higher TpO2 than nontreated group. These results indicate that the improvement of brain edema and metabolite levels were due to alleviation of ischemic hypoxia by FDA under the same ischemic insult.

Animals↗
PubMed1990

[Evaluation of aortocoronary bypass operation using a He-Ne laser flowmeter--comparison between internal mammary artery grafts and saphenous vein grafts].

It was very difficult to measure myocardial blood flow in clinical cases. Recently, a He-Ne laser doppler flowmeter was developed, and we made it possible to measure the pre-and post-operative myocardial blood flow in cases of coronary artery bypass grafting (CABG). We applied a laser flowmeter to 30 cases of bypass grafting to the left anterior descending coronary artery (18 cases with IMAG and 12 cases with SVG). The preoperative myocardial blood flow at the right ventricular anterior wall was 77 +/- 15 ml/min/100 gr, and the postoperative flow at the same point was 81 +/- 12 ml/min/100 gr. There was no significant change between the pre-operative value and the postoperative one. Myocardial blood flow at the left ventricular anterior wall in SVG group significantly increased from the preoperative value of 58 +/- 11 ml/min/100 gr to the postoperative value of 86 +/- 9 ml/min/100 gr (p less than 0.001). In IMAG group, myocardial blood flow at the left ventricular anterior wall similarly increased from 73 +/- 14 ml/min/100 gr to 83 +/- 15 ml/min/100 gr (p less than 0.01). The postoperative value of IMAG group was almost equal to the value of SVG group. The increased rate of myocardial blood flow at the left ventricular anterior wall was 52 +/- 32% in SVG group and 18 +/- 12% in IMAG group. These rates were obviously distinguished from the increased rate at the right ventricular anterior wall.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1990

[A case of metastatic ureteral tumor].

We report a case of metastatic ureteral tumor resulting from gastric cancer in a 56-year-old female. She had undergone distal gastrectomy for gastric cancer in our hospital 3 years earlier, on the histological diagnosis of poorly differentiated adenocarcinoma with absolute curative resection. In March, 1987, she visited our hospital complaining of microscopic hematuria and lumbago. Intravenous pyelography and left retrograde pyelography revealed the stenotic change of the left ureter and hydronephrosis. Endoscopic ureteral biopsy was performed, and the histological diagnosis was an inflammatory change of the ureter. But the hydronephrosis increased, so partial ureterectomy was performed. The histological examination confirmed adenocarcinoma in the left ureter resulting from gastric cancer. From the 340th postoperative day, she complained of general fatigue and vomiting, and gastroscopy revealed recurrent gastric cancer.

Adenocarcinoma↗
PubMed1990

[Care of cardiac insufficiency and laboratory test informations].

Measurement of serum myoglobin, CK-MM isoforms and CK-MB isoenzyme protein are useful for diagnosis and therapy of acute myocardial infarction (AMI). As latex agglutination turbidimetry of serum myoglobin is an easy and rapid assay method, it can be applied for early diagnosis of AMI and its observation of progress after break out of AMI. CK-MM isoforms also can be applicable for early diagnosis of AMI. The assay method of CK-MB isoenzyme protein by immunochemiluminescence is useful for anticipating the infarct size of AMI since this format is not influenced by CK-BB, myokinase, or mitochondria CK.

Clinical Enzyme Tests↗
PubMed1990

[Determination of hepatitis B virus pre-S 2 antigen by reversed passive hemagglutination and its clinical significance].

Pre-S 2 antigen has been distinct as one of the hepatitis B virus (HBV) markers recently. We detected Pre-S 2 antigen by reversed passive hemagglutination (R-PHA) in 98 samples and investigated the correlation between Pre-S 2 antigen and other HBV markers. Forty-two samples in 98 surface(s) antigen positive samples were positive for Pre-S 2 antigen (42.9%). Nineteen samples in 21 e antigen positive samples and 20 samples in 74 e antibody samples were positive for Pre-S 2 antigen (90.5% and 27.0% respectively). Pre-S 2 antigen titers by half quantitative 2n dilution method ranged from 256 to 2048 or more in e antigen positive samples and from 8 to 64 in e antibody positive samples. They showed two-peak distributions. There were no significant correlation between Pre-S 2 antigen titers and GPT values. In conclusion, determination of Pre-S 2 antigen might be one of the useful indexes of proliferation of HBV.

Adult↗
PubMed1990

[Study of chromogenic substrate on protein C activity assay--in patients treated with warfarin].

Protein C is an anticoagulant protein that circulates in blood as a zymogen of a serine protease. Recently the exogenous Protein C activator has been obtained from the venom of Agkistrodon Contortrix Contortrix. We also reported a functional assay method which activates Protein C with PROTAC and then measure the amidolytic activity with chromogenic substrate (S-2366) by COBAS FARA. At present, S-2366 (Glu-Pro-Arg-pNA), CBS 65-25 (Lys-Pro-Arg-pNA) and SPECTROZYME PCa (Lys-Pro-Arg-pNA) are used as the chromogenic substrate for activated Protein C. We studied which substrate is more suitable for amidolytic activity assay for Protein C by PROTAC in 99 patients under long-term Warfarin therapy and 29 as normal subjects. Our results indicate that SPECTROZYME PCa and CBS 65-25 are unsuitable for Protein C activity assay with PROTAC. Because change of absorbance was detected in Protein C deficient plasma and we couldn't gain good correlation between amidolytic activity of activated Protein C measured with these chromogenic substrates and antigenicity of Protein C by EIA. On the other hand, S-2366 is the most specific for activated Protein C and we also obtained good correlation against Protein C antigen.

Chromogenic Compounds↗
PubMed1990

[Reconstruction of radicular arteries in the total replacement of thoracoabdominal aorta].

A technique of reconstructing low intercostal, high lumbar arteries and Adamkiewicz artery is described to prevent paraplegia following operations on the thoracoabdominal aorta. A graft with a side branch is anastomosed proximally and a side branch to the distal thoracic aorta after reinforcement of the stumps under the partial bypass. Applying a clamp on the main graft, flow through the side branch and true lumen of the aneurysm is reestablished and bypass is terminated. The main graft, extended with a Y-graft, is anastomosed to common iliac arteries after proximal suture-ligation to perfuse the lower extremities. Splanchnic arteries are reconstructed according to DeBakey's technique which is followed by trimming of the thoracoabdominal aorta incising longitudinally with a clamp applied on the 1st side branch. Edges of the trimmed aneurysm are sutured to the slit of the graft from the right common iliac artery reconstructing intercostal, lumbar arteries and Adamkiewicz artery from the level of L2 upwards to T4 or more. As a final step, the graft is sutured to the 1st side branch allowing perfusion distally to the right lower extremity and the main graft to the splanchnic arteries and left lower extremity after division of a Y-graft right branch. The technique minimizes ischemic time for reconstruction of the aortic branches and enables complete reconstruction of the radicular arteries.

Aorta, Abdominal↗
PubMed1990

[Early detection of successful reperfusion by analysis of serum myoglobin in patients with acute myocardial infarction].

We examined the changes of serum myoglobin (Mb) levels after reperfusion therapy (PTCR, PTCA) in 24 patients with acute myocardial infarction by latex agglutination turbidimetry. In the cases of 13 patients successfully reperfused, significantly higher Mb levels was observed and they disappeared rapidly from blood after the therapy. On the other hand, serum Mb levels disappeared slowly in the cases of patients unsuccessfully reperfused. The disappearance rate of Mb (23.4 +/- 6.7%) in successful reperfused patients was higher than that in unsuccessful reperfusion (5.3 +/- 6.8%) (p less than 0.001), the cut-off value of serum Mb levels in the decision regarding success or failure of reperfusion was set at 17% of disappearance rate, the predictive values for successful and unsuccessful reperfusion were 92% and 91% respectively. The maximum peak time of CK, CK-MB activities and Mb levels after onset of chest pain were also observed. Only the maximum peak time of CK-MB was significantly fasten than others in the cases of patients sera with successful reperfusion (p less than 0.05). We conclude that the measurement of serum Mb levels was useful and suitable for rapid judging on success or failure of reperfusion therapy by use of the disappearance rate of it.

Evaluation Studies as Topic↗
PubMed1990

[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].

Adrenocortical hormones have been used for nephrotic syndrome from 1950. But effects of these drugs in coagulation and fibrinolysis are unknown in detail. We studied the effect of prednisolone in a patient with nephrotic syndrome. Protein C increased remarkably after administration of prednisolone 40 mg/day and then decreased in parallel with the dose of prednisolone. Factor X increased more slowly than Protein C. On the other hand, we couldn't find increase of Protein S. Our results indicate that prednisolone have anticoagulant effect by promotion of production of Protein C.

Blood Coagulation↗