Biomedical subjects

Y Katano

Publications and source records attributed to Y Katano.

93 records · Page 6Linked to original sources

PubMedDate not supplied

An autopsy case of multilocular cystic hepatocellular carcinoma without liver cirrhosis.

Although simple cysts, cystadenoma and cystadenocarcinoma of the liver have been well documented as hepatic cystic diseases, cystic hepatocellular carcinoma is a curious entity. Only 3 cases have been reported in the English literature. A 70-year-old man was admitted to Nagoya University Hospital for multiple liver tumors and a thrombus in the main trunk of the portal vein. A part of the tumors contained cystic components, and were diagnosed as hepatocellular carcinoma by needle biopsy. After giving informed consent, the patient was treated with several systemic chemotherapy using doxorubicin, fluorouracil, cyclophosphamide, cisplatin and oral anticancer agent UFT, a combination of uracil and tegafur, for almost 2 years. During this time, the tumors enlarged gradually, and also underwent cyst formation, the patients then died of biliary sepsis. Autopsy confirmed the diagnosis of multilocular cystic hepatocellular carcinoma without liver cirrhosis.

Aged↗

PubMedDate not supplied

A case of the development of two hepatocellular carcinomas and a cholangiocarcinoma with cirrhosis after elimination of serum hepatitis C virus RNA with interferon therapy.

A 64-year-old man who had exhibited abnormal transaminase levels for about 20 years was admitted to a hospital for the treatment of liver damage. Laboratory testing demonstrated that he was suffering from chronic hepatitis C, and a liver biopsy showed chronic active hepatitis with septal fibrosis. He was treated with interferon-alpha, and HCV-RNA became undetectable. Four years after the completion of interferon treatment, 3 lesions in the patient's liver were revealed by routine ultrasonography, and he was referred to Nagoya University Hospital for further examinations on November 1997. Radiographical examinations such as computed tomography and angiography demonstrated 2 hypervascular tumors (size: phi 35 mm and phi 20 mm) and 1 hypovascular tumor (phi 28 mm). Qualitative analysis for HCV-RNA by polymerase chain reaction method was negative. Partial hepatectomy was performed, and pathological examination of the tumors showed 2 moderately differentiated hepatocellular carcinomas and cholangiocarcinoma accompanied with liver cirrhosis. We propose that even patients with disappearance of HCV-RNA after interferon therapy, especially with liver cirrhosis or severe fibrosis, should be followed-up closely and examined at regular intervals because of the high risk of developing primary liver cancers.

Carcinoma, Hepatocellular↗

PubMedDate not supplied

Effects of catecholamines on myocardial energy metabolism as studied by an organ redoximeter.

With the use of an organ redoximeter, the effects of noradrenaline, adrenaline, isoproterenol, and phenylephrine on the oxidation-reduction state of the myocardial pyridine nucleotides were studied in the canine heart-lung preparation supported by a donor. Noradrenaline and adrenaline produced an initial, transient improvement, and phenylephrine a sustained improvement, of the redox state, while isoproterenol produced a depression. Pretreatment of the preparation with adrenergic alpha-blockers resulted in an abolishment of the improvement by noradrenaline, adrenaline, and phenylephrine, while the depression by isoproterenol remained unchanged. Whereas noradrenaline and adrenaline produced a sustained improvement after an adrenergic beta-blocker, propranolol, the effect of isoproterenol was abolished. These findings suggest that sympathomimetic amines can produce an improvement of the myocardial energy metabolism through activation of the adrenergic alpha-receptor. The depression of the myocardial oxidation-reduction state was taken to represent an acceleration of glycolysis.

Animals↗