Biomedical subjects
Y Kahanowicz
Publications and source records attributed to Y Kahanowicz.
Ocular anti-inflammatory effect of fenoprofen. Dose-response study.
An experimental rabbit uveitis model was used to establish a dose response range for topical administration of fenoprofen (dl-2(3-phenoxyphenyl) propionic acid. The 0.3% concentrate group was not distinguishable from the untreated group, and 3% concentrate proved highly irritating. Fenoprofen 1%, pH 6.4, proved most efficacious and had an effect comparable to dexamethasone phosphate 0.1%, seen in a previous study.
Unsuccessful eccentric perilimbal suction after filtering surgery.
Eccentric suction was applied over the surgical site in 47 eyes thought to have unsuccessful external filtering procedures. Referrals for suction were made either because the postoperative intraocular pressure was uncontrolled or because blebs were becoming progressively flatter. Patients had an average of seven such treatment sessions. No discernible benefit from eccentric suction in failing filtering surgery was noted one year postoperatively.
Corneal anesthesia induced by soaps and surfactants, lack of correlation in rabbits and humans.
Five commonly marketed bath and facial soaps and four commercially available hair shampoos were studied for their anesthetic effect on human and rabbit corneas. These compounds all produced anesthesia comparable to that induced by tetracaine hydrochloride 0.5 percent but lasting several hours longer in rabbits. None of the soaps or shampoos produced corneal anesthesia in humans. Studies of corneal anesthesia in rabbits may not be extrapolated to the human eye.
Pump infusion of pilocarpine.
Pilocarpine was infused into the conjunctival sac of glaucoma patients with the Sage Model 216 pump. Doses as high as 20 mg were given in 30 min without ocular or systemic toxicity. The ocular hypotension effect, in the same group of patients, was doubled over 4-percent pilocarpine drops given four times daily. In addition to increased efficacy the duration of the ocuoar hypotensive effect was markedly prolonged. Return of ocular pressure to baseline values after a single pump infusion of 20 mg required an average of 33.9 h.