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Biomedical subjects

Y Kadoi

Publications and source records attributed to Y Kadoi.

42 records · Page 3Linked to original sources
PubMed1996

[Anesthetic management of a patient with dilated cardiomyopathy].

Using transesophageal echocardiography (TEE), we managed the anesthesia for a patient with dilated cardiomyopathy (DCM). Anesthesia was induced with midazolam and fentanyl, and vecuronium was used as a muscle relaxant. Anesthesia was maintained with oxygen-nitrous oxide-low concentration isoflurane. After the induction of anesthesia ejection fraction was 20%, but increased to 41% with the administration of dobutamine and amrinone. We conclude that TEE is a useful monitor in anesthetic management of a patient with DCM.

Anesthesia, General↗
PubMed1995

Augmented sensitivity to benzodiazepine in septic shock rats.

The purpose of this study was to assess the pharmacological characteristics of the benzodiazepine binding site in the brain of septic animals. We induced endotoxin shock in rats using a caecum ligation and puncture model. Following examination of the physiological state of the rats 24 hr after the caecum ligation and puncture, brain tissue samples were prepared for biochemical assay of amino acids and for the [3H]-diazepam radioligand binding assay. Amino acids assays indicated that the concentration of aromatic amino acids was higher in the CLP group (P< 0.05), the branched chain amino acid concentration was lower in the CLP group (P< 0.05) and the sulfur-containing amino acid concentration was elevated in the CLP group (P< 0.05) than in both the control and the sham-operated groups. [3H]-diazepam radioligand binding assays demonstrated that the number of receptors in the septic rats was increased in the forebrain (CLP rats; 2.37 +/- 0.04 pmol x mg(-1) protein, control rats; 1.45 +/- 0.02 pmol x mg(-1) protein, sham-operated rats; 1.49 +/- 0.03 pmol x mg(-1) protein), cerebellum (CLP rats; 1.55 +/- 0.05 pmol x mg(-1) protein, control rats; 1.05 +/- 0.02 pmol x mg(-1) protein, sham-operated rats: 1.09 +/- 0.02 pmol x mg(-1) protein) and brain stem (CLP rats; 1.21 +/- 0.04 pmol x mg(-1) protein, control rats; 0.61 +/- 0.02 pmol x mg(-1) protein, sham-operated rats; 0.63 +/- 0.02 pmol x mg(-1) protein) compared with the control and sham-operated rats (P< 0.05). In conclusion, it was considered that the increased number of benzodiazepine receptors may be one cause of the neuronal alteration observed in septic shock animals.

Amino Acids↗
PubMed1995

[Effects of anesthetic drugs and temperature on brain stem and mid-latency evoked potentials].

We evaluated the effects of anesthetic drugs and temperature on brain stem and mid-latency evoked potentials (BAEP and MLAEP) in 20-patients who were scheduled for elective cardiac operation using cardiopulmonary bypass with moderate hypothermia. At esophageal temperature of 36 degrees C, the latency of MLAEP was slightly prolonged by the increase of fentanyl dose, which suggested that the latency prolongation of MLAEP could not block the oscillation of auditory stimulation. At esophageal temperature of 27 degrees C, the latency of MLAEP nearly disappeared, and the latency of MLAEP gradually returned with the recovery of the esophageal temperature. The latency of BAEP was markedly prolonged at 27 degrees C and returned to the normal latency at 36 degrees C. The latency of MLAEP retained by high dose fentanyl suggests that patients may be aware during cardiopulmonary bypass at normothermia, and BAEP may be one of the useful brain function monitors during cardiopulmonary bypass.

Adolescent↗
PubMed1995

[Alterations of the brain stem and mid-latency evoked potentials under oxygen-nitrous oxide-sevoflurane anesthesia].

We evaluated the alterations of the brain stem and mid-latency evoked potentials (BAEP and MLAEP) in 10-patients who were scheduled for elective abdominal surgery under oxygen-nitrous oxide-sevoflurane anesthesia. With oxygen 2 l.min-1 and nitrous oxide 4 l.min-1, we measured the latency of BAEP and MLAEP at the end-expired sevoflurane concentrations of 0%, 0.3%, 0.6%, 1.0%, 1.5% and 2.0%, respectively. The latency of BAEP was slightly prolonged with oxygen-nitrous oxide-sevoflurane anesthesia. The latency of MLAEP was markedly prolonged with the increase of sevoflurane concentration, and all waves but Na wave disappeared at the 2.0% sevoflurane concentration.

Abdomen↗
PubMed1989

Comparative clinical study of induction and emergence time in sevoflurane and enflurane anaesthesia.

The induction and emergence times in patients who received minor oral surgery under sevoflurane with nitrous oxide or enflurane with nitrous oxide were compared. The induction time required for the loss of eyelid reflex when using sevoflurane (1.6 +/- 0.2 min) was significantly shorter than that in the enflurane group (2.9 +/- 0.4 min). There was no significant difference in the recovery time in the two groups.

Adult↗