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Biomedical subjects

Y J Hong

Publications and source records attributed to Y J Hong.

42 records · Page 3Linked to original sources
PubMed1988

Comparison of the Tono-Pen to the Goldmann applanation tonometer.

Oculab Tono-Pen tonometry was compared with Goldmann applanation tonometry in 142 eyes of 71 patients without corneal problems. Overall we found 63% of the Tono-Pen readings to be within +/- 2 mm Hg of the Goldmann applanation tonometry readings and 77% to be within +/- 3 mm Hg, while 4% were within at least +/- 7 mm Hg difference. The correlation coefficient between the readings of the two instruments was .84. The mean value of the paired differences was 0.81 +/- 3.09 mm Hg overall, -1.78 +/- 1.86 mm Hg in the 4 to 10 mm Hg interval, 0.07 +/- 2.97 mm Hg in the 11 to 20 mm Hg interval, 1.27 +/- 2.62 mm Hg in the 21 to 30 mm Hg interval, and 4.15 +/- 2.28 mm Hg in the 31 to 45 mm Hg interval. We conclude that the Tono-Pen measures intraocular pressure in a manner that corresponds well to the Goldmann tonometer in the 11 to 20 mm Hg interval, and fairly well in the 4 to 10 mm Hg and 21 to 30 mm Hg intervals. It lacks good correspondence in the 31 to 45 mm Hg interval.

Humans↗
PubMed1987

Bilateral effects of long-term monocular timolol therapy.

We studied the bilateral intraocular pressure lowering effect of long-term unilateral timolol maleate 0.5% in 30 patients in whom early primary open-angle glaucoma had recently been diagnosed. A significant intraocular pressure reduction was found in the untreated fellow eyes (21.9 mm Hg from 26.4 mm Hg at baseline) (P less than .001), as well as in the treated eyes (21.0 mm Hg from 28.5 mm Hg at baseline) (P less than .001). Fourteen patients (47%) showed a significant bilateral intraocular pressure reduction (P less than .001), with little difference between the treated (8.2 mm Hg) and the untreated eyes (7.7 mm Hg) (P greater than .8).

Adult↗
PubMedDate not supplied

Comparisons of intraocular-pressure- lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide.

Forty-one healthy volunteers were recruited for a study to compare the intraocular pressure (IOP)-lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide. In a randomized double-blind design, one eye received one drop of 2% dorzolamide and the other eye received one drop of 1% brinzolamide. The IOP and side effects were evaluated by Goldmann applanation tonometry and slit lamp biomicroscopy before administration, and 3, 7 and 14 days after the initial administration of eyedrops. The IOP decreased significantly from baseline for both drugs (p < 0.05). However, there were no statistically significant differences between 2% dorzolamide and 1% brinzolamide either before or after eyedrop administration (p > 0.05). The most frequent side effect was ocular pain in the case of 2% dorzolamide and blurred vision in 1% brinzolamide. The results suggested that 2% dorzolamide and 1% brinzolamide have similar IOP-lowering efficacies with different side effects

Adult↗
PubMedDate not supplied

Effect of 0.2% brimonidine in preventing intraocular pressure elevation after Nd:YAG laser posterior capsulotomy.

BACKGROUND AND OBJECTIVE: To determine the prophylactic effect of 0.2% brimonidine in reducing the elevated intraocular pressure (IOP) in patients undergoing Nd:YAG laser posterior capsulotomy. PATIENTS AND METHODS: The 81 patients (81 eyes), who underwent Nd:YAG laser posterior capsulotomy, were allocated to two treatment groups. One drop of 0.2% brimonidine or vehicle was instilled 1 hour preoperatively and one drop immediately after capsulotomy. IOPs were measured preoperatively and 1, 2, 3, and 24 hours postoperatively. RESULTS: Intraocular pressure decreased from the baseline in the brimonidine group by the third postoperative hour (P<0.05), while the vehicle group exhibited an increase. Intraocular pressure elevations of 5 mm Hg or greater occurred in 7.3% (3/41) in the brimonidine group compared to 20.0% (8/40) in the vehicle group. IOP elevations of 10 mm Hg or greater occurred in 2.4% (1/41) in the brimonidine group compared to 7.5% (3/40) in the vehicle group. CONCLUSIONS: One drop of 0.2% brimonidine instilled 1 hour preoperatively and immediately after capsulotomy was found to be efficacious and safe in preventing IOP elevations that frequently follow Nd:YAG laser posterior capsulotomy.

Adrenergic alpha-Agonists↗